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Target
SRSF protein kinase 1
Ligand
BDBM504520
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
2.53±n/a nM
Citation
 Hatcher, J; Gray, NS; Choi, H; Janne, P; Zhang, T Substituted 6,11-dihydro-5H-benzo[B]carbazoles as inhibitors of ALK and SRPK US Patent  US11066363 Publication Date 7/20/2021 
Target
Name:
SRSF protein kinase 1
Synonyms:
SRPK1 | SRPK1_HUMAN | SRSF protein kinase 1 (SRPK1) | Serine/arginine-protein kinase 1 (SRPK1) | Serine/threonine-protein kinase SRPK1
Type:
Protein
Mol. Mass.:
74318.38
Organism:
Homo sapiens (Human)
Description:
Q96SB4
Residue:
655
Sequence:
MERKVLALQARKKRTKAKKDKAQRKSETQHRGSAPHSESDLPEQEEEILGSDDDEQEDPNDYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQKRPNKQEESESPVERPLKENPPNKMTQEKLEESSTIGQDQTLMERDTEGGAAEINCNGVIEVINYTQNSNNETLRHKEDLHNANDCDVQNLNQESSFLSSQNGDSSTSQETDSCTPITSEVSDTMVCQSSSTVGQSFSEQHISQLQESIRAEIPCEDEQEQEHNGPLDNKGKSTAGNFLVNPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWLNS
  
Inhibitor
Name:
BDBM504520
Synonyms:
9-ethyl-6,6-dimethyl-11-oxo-8- (pyrimidin-5-yl)-6,11-dihydro-5H- benzo[b]carbazole-3-carbonitrile | US11066363, Compound 16
Type:
Small organic molecule
Emp. Form.:
C25H20N4O
Mol. Mass.:
392.4525
SMILES:
CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1-c1cncnc1
Structure:
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