Reaction Details Report a problem with these data
Target
Prostaglandin D2 receptor 2
Ligand
BDBM50363917
Substrate
n/a
Meas. Tech.
ChEMBL_805476 (CHEMBL1955369)
IC50
32±n/a nM
Citation
 Liu, J; Li, AR; Wang, Y; Johnson, MG; Su, Y; Shen, W; Wang, X; Lively, S; Brown, M; Lai, S; Gonzalez Lopez De Turiso, F; Xu, Q; Van Lengerich, B; Schmitt, M; Fu, Z; Sun, Y; Lawlis, S; Seitz, L; Danao, J; Wait, J; Ye, Q; Tang, HL; Grillo, M; Collins, TL; Sullivan, TJ; Medina, JC Discovery of AMG 853, a CRTH2 and DP Dual Antagonist. ACS Med Chem Lett 2:326-330 (2011) [PubMed]  Article 
Target
Name:
Prostaglandin D2 receptor 2
Synonyms:
Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | G-protein coupled receptor 44 | Prostaglandin D2 receptor 2 | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | Prostaglandin D2 | CD_antigen=CD294 | Prostaglandin D2 receptor 2 (PGD2) | PD2R2_HUMAN | PTGDR2 | CRTH2 | DL1R | GPR44 | G protein-coupled receptor 44
Type:
Enzyme
Mol. Mass.:
43295.45
Organism:
Human
Description:
Q9Y5Y4
Residue:
395
Sequence:
MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCRMRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRIMCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRRPGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVANPVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRPEEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
  
Inhibitor
Name:
BDBM50363917
Synonyms:
CHEMBL1951566
Type:
Small organic molecule
Emp. Form.:
C25H22Cl2F2N2O6S
Mol. Mass.:
n/a
SMILES:
CCCCNC(=O)c1ccc(Oc2cc(F)c(CC(O)=O)cc2F)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1
Structure:
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