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Target
Protein arginine N-methyltransferase 1
Ligand
BDBM50550120
Substrate
n/a
Meas. Tech.
ChEMBL_2026409 (CHEMBL4680567)
IC50
16300±n/a nM
Citation
 Qian, K; Yan, C; Su, H; Dang, T; Zhou, B; Wang, Z; Zhao, X; Ivanov, I; Ho, MC; Zheng, YG Pharmacophore-based screening of diamidine small molecule inhibitors for protein arginine methyltransferases. RSC Med Chem 12:95-102 (2021) [PubMed]  Article 
Target
Name:
Protein arginine N-methyltransferase 1
Synonyms:
2.1.1.319 | HRMT1L2 {ECO:0000303|PubMed:11097842 | Histone-arginine N-methyltransferase PRMT1 | Interferon receptor 1-bound protein 4 | Protein arginine N-methyltransferase 1 | Synonyms=HMT2 | ANM1_HUMAN | PRMT1 | HMT2 | HRMT1L2 | IR1B4 | Protein-arginine N-methyltransferase 1
Type:
PROTEIN
Mol. Mass.:
42451.61
Organism:
Human
Description:
ChEMBL_100878
Residue:
371
Sequence:
MAAAEAANCIMENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR
  
Inhibitor
Name:
BDBM50550120
Synonyms:
CHEMBL167317
Type:
Small organic molecule
Emp. Form.:
C28H25N5O
Mol. Mass.:
447.54
SMILES:
C1CN=C(N1)c1ccc(Oc2ccc(\C=C\c3cc4ccc(cc4[nH]3)C3=NCCN3)cc2)cc1 |c:2,t:28|
Structure:
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