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Target
17-beta-hydroxysteroid dehydrogenase 13
Ligand
BDBM714807
Substrate
n/a
Meas. Tech.
17beta-HSD13 Biochemical Assay
IC50
3.23±n/a nM
Citation
 Zablocki, J; Koltun, D; Javanbakht, H; Chu, K; Deval, J 17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 13 INHIBITORS AND METHODS OF USE THEREOF US Patent  US20250026745 Publication Date 1/23/2025 
Target
Name:
17-beta-hydroxysteroid dehydrogenase 13
Synonyms:
17-beta-HSD 13 | Hepatic retinol/retinal dehydrogenase | Short chain dehydrogenase/reductase family 16C member 3 | Short-chain dehydrogenase/reductase 9
Type:
Protein
Mol. Mass.:
33667.14
Organism:
Human
Description:
Q7Z5P4
Residue:
300
Sequence:
MNIILEILLLLITIIYSYLESLVKFFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRKLGVTAHAYVVDCSNREEIYRSLNQVKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNTGFTKNPSTRLWPVLETDEVVRSLIDGILTNKKMIFVPSYINIFLRLQKFLPERASAILNRMQNIQFEAVVGHKIKMK
  
Inhibitor
Name:
BDBM714807
Synonyms:
6-benzyl-4-((5-(2,4,5-trifluoro-3- hydroxyphenyl)-1,3,4-thiadiazol-2- yl)methyl)-4,6- diazaspiro[2.4]heptane-5,7-dione | US20250026745, Compound I-69
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
O=C1N(Cc2ccccc2)C(=O)C2(CC2)N1Cc1nnc(-c2cc(F)c(F)c(O)c2F)s1
Structure:
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