Reaction Details Report a problem with these data
Target
High affinity nerve growth factor receptor
Ligand
BDBM50224528
Substrate
n/a
Meas. Tech.
ChEMBL_2263728
IC50
1.5±n/a nM
Citation
 Sun, M; Cai, S; Li, P; Zhang, F; Zhang, H; Zhou, J Design, synthesis and biological activity of bicyclic carboxamide derivatives as TRK inhibitors. Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
High affinity nerve growth factor receptor
Synonyms:
TRKA GN | Neurotrophic tyrosine kinase receptor type 1 | TRK | TRK1-transforming tyrosine kinase protein | Tropomyosin alpha-3 chain/High affinity nerve growth factor receptor | Trk-A | NTRK1_HUMAN | Tyrosine kinase receptor | NTRK1 | Tropomyosin-related kinase A | Nerve growth factor receptor Trk-A | TRKA GN | 2.7.10.1 | Tyrosine kinase receptor A (TrkA) | Synonyms=MTC | Tyrosine kinase receptor A (Trk-A) | Tyrosine kinase receptor (Trk) | gp140trk | Tyrosine kinase receptor A | Tropomyosin-related kinase A (TrkA) | Tyrosine kinase receptor A (Trk A) | TRKA | NTRK1/NTRK2 | p140-TrkA | Neurotrophic tyrosine kinase receptor type 1 (TrkA) | MTC
Type:
n/a
Mol. Mass.:
87498.18
Organism:
Human
Description:
P04629
Residue:
796
Sequence:
MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG
  
Inhibitor
Name:
BDBM50224528
Synonyms:
CHEMBL5275171
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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