Reaction Details Report a problem with these data
Target
Beta-2 adrenergic receptor
Ligand
BDBM50250422
Substrate
n/a
Meas. Tech.
ChEMBL_1499796 (CHEMBL3582626)
Ki
>950±n/a nM
Citation
 Madapa, S; Harding, WW Semisynthetic Studies on and Biological Evaluation of N-Methyllaurotetanine Analogues as Ligands for 5-HT Receptors. J Nat Prod 78:722-9 (2015) [PubMed]  Article 
Target
Name:
Beta-2 adrenergic receptor
Synonyms:
ADRB2_HUMAN | Beta-2 adrenoceptor | ADRB2 | ADRB2R | Beta-2 adrenoreceptor | B2AR
Type:
n/a
Mol. Mass.:
46461.69
Organism:
Human
Description:
P07550
Residue:
413
Sequence:
MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
  
Inhibitor
Name:
BDBM50250422
Synonyms:
N-methyllaurotetanine | (+)-N-methyl-laurotetanine | CHEMBL464099
Type:
Small organic molecule
Emp. Form.:
C20H23NO4
Mol. Mass.:
341.16
SMILES:
COc1cc-2c(C[C@@H]3N(C)CCc4cc(OC)c(OC)c-2c34)cc1O |r|
Structure:
Search PDB for entries with ligand similarity: