| Assay Method Information | |
| | Isothermal Titration Calorimetry Studies of STAT3 Binding |
| Description: | The binding isotherm from the integrated thermogram fit using the one-site model in the PEAQ-ITC software generated from the titration of Compound 1 into purified STAT3 show KD of 880 nM. The signature plot show the thermodynamics parameters for the titration reveals ΔH=−21.1 kJ/mol, ΔG=−34.6 kJ/mol, and −TΔS=−13.2 kJ/mol. |
| Affinity data for this assay | |
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