| Assay Method Information | |
| | Evaluation of the Gmps Inhibitors Potency |
| Description: | The potency of the five compounds was tested against recombinant GMPS in an enzymatic assay by monitoring UV absorbance at 290 nm and by determining an IC50. The IC50 values obtained are summarized in Table 3. Three compounds (1, 2 and 4) inhibited GMPS with nanomolar IC50 values while the other two (3 and 5) were found less active. The structure-activity relationship (SAR) indicated that the chloroacetamide group is essential for potent binding to GMPS. |
| Affinity data for this assay | |
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