| Assay Method Information | |
| | PI3Kα Inhibitors In Vitro |
| Description: | The results detailed above served to identify P-selectin as a target for tumor selective drug delivery and that the high affinity of fucoidan for P-selectin can be exploited to deliver locally therapeutically effective doses of the PI3K inhibitor BYL719, avoiding potentially toxic systemic drug exposure. Next, attention was turned to novel PI3K inhibitors with superior in vivo characteristics with respect to antitumor efficacy and known, mechanism-based PI3K liabilities. |
| Affinity data for this assay | |
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