| Assay Method Information | |
| | Dose Response for ABC transporter inhibitors: specifically ABCG2 screen, ABCB1 counter-screen |
| Description: | University of New Mexico Assay Overview: Assay Support:1R03MH081228-01A1 High-throughput multiplex screening for ABC transporter inhibitors PI: Richard Larson MD, PhD Assay Development: Irena Ivnitski-Steele PhD Assay Implementation: Irena Ivnitski-Steele PhD, Juan Strouse PhD, Terry Foutz, Anna Waller PhD, Mark Carter Target Team Leader for the Center: Bruce Edwards, PhD (BEdwards@salud.unm.edu Assay Background and Significance: The three major types of multidrug resistance (MDR) proteins in humans include members of the ABCB, the ABCC and the ABCG subfamilies. These proteins influence oral absorption and disposition of a wide variety of drugs. As a result, their expression levels have important consequences for susceptibility to drug-induced side effects, interactions, and treatment efficacy. One of the most widely studied MDR-ABC transporter is P-glycoprotein (MDR or ABC B1 transporter). This protein functions to remove lipids and drugs as they intercalate and diffuse throu |
| Affinity data for this assay | |
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