| Assay Method Information | |
| | Luminescent counterscreen for inhibitors of the Janus kinase 2 mutant JAK2V617F: dose response cell-based high throughput screening assay for inhibitors of parental Ba/F3 cell viability. |
| Description: | Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TSRI) Assay Provider: Ross Levine, Memorial Sloan Kettering Cancer Center (MSKCC) Network: Molecular Libraries Probe Production Centers Network (MLPCN) Grant Proposal Number: 1 R03 MH084174-01 Grant Proposal PI: Ross Levine, MSKCC External Assay ID: BaF3CYTOX_INH_LUMI_384_3XIC50 Name: Luminescent counterscreen for inhibitors of the Janus kinase 2 mutant JAK2V617F: dose response cell-based high throughput screening assay for inhibitors of parental Ba/F3 cell viability. Description: Regulation of the differentiation and activity of inflammatory cells through cytokine signaling is essential for proper immune function and to prevent auto-immune disease and leukemias (1, 2). The protein tyrosine kinase Janus kinase 2 (JAK2) is critical for this process (3-6). Following activation of cytokine receptors, particularly erythropoietin and interf |
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