Assay Method Information | |
| Luminescence-based dose response biochemical high throughput screening assay for inhibitors of the Heat Shock Protein 90 (HSP90) |
Description: | Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TSRI) Assay Provider: Robert Matts, Oklahoma State University Network: Molecular Libraries Probe Production Centers Network (MLPCN) Grant Proposal Number: 1 X01 MH083240-01 Grant Proposal PI: Robert Matts, Oklahoma State University External Assay ID: HSP90_INH_LUMI_1536_3XIC50 Name: Luminescence-based dose response biochemical high throughput screening assay for inhibitors of the Heat Shock Protein 90 (HSP90) Description: Hsp90 is a ubiquitously conserved molecular chaperone (1, 2) that assists the folding of client substrates involved in a variety of human disorders characterized by dysregulated cell proliferation (ie, cancer and viral infections), accumulation of protein aggregates (ie, neurodegenerative diseases) and stress-induced apoptotic cell death (ie, multiple sclerosis) (3). Its diverse biology stems in part from interactions |
Affinity data for this assay | |
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