Assay Method Information

Assay Name:  Dosage response for compounds that protect hERG from block by proarrhythmic agents using manual patch clamp
Description:  Data Source: Johns Hopkins Ion Channel Center BioAssay Type: Mode of action, Concentration-Response Relationship Observed Source (MLPCN Center Name): Johns Hopkins Ion Channel Center (JHICC) Center Affiliation: Johns Hopkins University, School of Medicine Screening Center PI: Min Li, Ph.D. Assay Provider: Dr. Sabina Kupershmidt, Vanderbilt University Medical Center Network: Molecular Libraries Probe Production Centers Network (MLPCN) Grant Proposal Number: 1R03MH084820-01 Grant Proposal PI: Dr. Sabina Kupershmidt, Vanderbilt University Medical Center Assay Implementation: Dr. Sabina Kupershmidt, Vanderbilt University Medical Center Name: Dosage response for compounds that protect hERG from block by proarrhythmic agents using manual patch clamp Description: See the related bioassay (AID: 1511). Principle of the assay Patch clamp is gold standard to measure channel activities. Upon depolarization of cells expressing potassium channels, in this case, human ether-a-go-go-related g
Affinity data for this assay
 

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