| Assay Method Information | |
| | Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of GLD-1 protein - TGE RNA interaction |
| Description: | Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assay Provider: James R. Williamson, TSRI Network: Molecular Library Probe Production Centers Network (MLPCN) Grant Proposal Number: 1 R21 NS056951-01 Grant Proposal PI: James R. Williamson External Assay ID: GLD1_INH_FP_1536_3XIC50 DRUN Name: Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of gld-1 protein - TGE RNA interaction. Description: Post-transcriptional control of gene expression, such as alternative splicing and tissue-specific silencing, allow for great protein diversity (1). The elements in the mRNA 3' untranslated regions (UTRs) influence the expression of genes involved in proliferation and differentiation of stem cells and germ cells (2). These elements are critical during spermatogenesis and oogenesis in hermaphrodite Caenorhabditis elegans nematodes (3). gld-1 (defective |
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