| Assay Method Information | |
| | Dose Response confirmation of inhibitors of hexokinase domain containing I (HKDC1) in the hexokinase 1 selectivity assay |
| Description: | Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) Network: NIH Molecular Libraries Probe Production Centers Network (MLPCN) Grant Proposal Number: R21 NS061703-01S1 Assay Provider: Dr. Jeff Johnson, Metabolex, Inc., Hayward, CA. Since hexokinases (HKs) are the first step in glucose metabolism, they play a major role in regulating the metabolic fate of glucose in the tissues they are expressed. Understanding both the proper and pathological metabolism of glucose is obviously of critical importance to deciphering the dysregulation of glucose that leads to Type 2 diabetes, a disorder of metabolism that morbidly afflicts 35 million Americans and perhaps close to 200 million worldwide. The gene HKDC1 (HexoKinase Domain Containing I) was found to encode a fifth mammalian hexokinase. Its expression pattern is unique among hexokinases, providing some initial clues to its function in biolog |
| Affinity data for this assay | |
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