| Assay Method Information | |
| | Fluorescence-based cell-based high throughput dose response assay for inhibitors of TLR9-MyD88 binding |
| Description: | Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assay Provider: Peter S. Tobias, The Scripps Research Institute (TSRI) Network: Molecular Library Probe Production Centers Network (MLPCN) Grant Proposal Number: RO1 AI078288 Grant Proposal PI: Peter S. Tobias, The Scripps Research Institute (TSRI) External Assay ID: TLR9_INH_BLA_1536_3XIC50 DRUN Name: Fluorescence-based cell-based high throughput dose response assay for inhibitors of TLR9-MyD88 binding. Description: Toll-like receptors (TLRs) are involved in initiating inflammatory responses to a number of components of pathogens as well as markers of sterile injury. As such they initiate homeostatic responses but also pathologic responses. Our focus on TLR9 is based on its role in autoimmune disease. Auto-antibodies to DNA, RNA, or both are characteristic of systemic lupus erythematosus (SLE) (1). Auto-antibody production depends on the |
| Affinity data for this assay | |
|---|---|
| If you find an error in this entry please send us an E-mail | |