| Assay Method Information | |
| | Counterscreen for biased ligands (agonists) of the melanocortin 4 receptor (MC4R) |
| Description: | Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRISMC) Center Affiliation: The Scripps Research Institute, TSRI Assay Provider: Scott DeWire, Trevena Inc Network: Molecular Library Probe Production Center Network (MLPCN) Grant Proposal Number: 1 RC2 MH090877-01 Grant Proposal PI: Scott DeWire, Trevena Inc External Assay ID: OPRM1-OPRD1_AG_LUMI_1536_3XEC50 DCSRUN Name: Counterscreen for biased ligands (agonists) of the melanocortin 4 receptor (MC4R): Luminescence-based cell-based high throughput dose response assay to identify agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors. Description: Heterotrimeric G-protein coupled receptors (GPCRs) are major targets for disease therapeutics, due in part to their broad tissue distribution, structural diversity, varied modes of action, and disease-associated mutations (1-4). However, it has recently been demonstrated that GPCRs do not only signal in this simplistic f |
| Affinity data for this assay | |
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