| Assay Method Information | |
| | Luminescence-based cell-based high throughput dose response assay to identify agonists of the DAF-12 from the parasite H. contortus (hcDAF-12) |
| Description: | Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assay Provider: David Mangelsdorf, UT Southwestern Network: Molecular Library Probe Production Centers Network (MLPCN) Grant Proposal Number: U19 DK062434 Grant Proposal PI: David Mangelsdorf, UT Southwestern External Assay ID: HCDAF12_ACT_LUMI_1536_3XEC50 DRUN Name: Luminescence-based cell-based high throughput dose response assay to identify agonists of the DAF-12 from the parasite H. contortus (hcDAF-12). Description: Parasitic helminthes (worms) are a significant health and economic burden: over two billion people are infected by helminthes (1), and parasitic nematodes cause billions of dollars of crop damage each year in the United States (2). The developmental stages of these organisms are widely studied (3, 4). One stage, dauer (German for "duration," also known as an alternative L3 larval stage) covers an alternative larval stage i |
| Affinity data for this assay | |
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