| Assay Method Information | |
| | Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of Trypanosoma brucei RNA editing ligase 1 (TbREL1). |
| Description: | Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute Assay Provider: Achim Schnaufer, The University of Edinburgh Network: Molecular Libraries Probe Production Centers Network (MLPCN) Grant Proposal Number: R21 NS06173301 Grant Proposal PI: Achim Schnaufer, The University of Edinburgh External Assay ID: TBREL1_INH_FRET_1536_3XIC50 DRUN Name: Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of Trypanosoma brucei RNA editing ligase 1 (TbREL1). Description: The trypanosomatid parasites T. brucei ssp., T. cruzi and Leishmania spp. are the causative agents of human African trypanosomiasis (HAT), Chagas' disease, and leishmaniasis, and economically important diseases in livestock. All trypanosomatids require a unique form of RNA editing for mitochondrial gene expression, and through conditional knockout studies in T. brucei in culture and in mice we ha |
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