| Assay Method Information | |
| | Inhibition of MMPs |
| Description: | MMPs-1, -2, -3, -7, -8 and -14 along with the SensoLyte 520 Generic MMP Activity Kit*Fluorimetric* were purchased from AnaSpec (Fremont, CA, USA). The assay was performed as described previously (Schönauer E, Kany A M, Haupenthal J, Hüsecken K, Hoppe I J, Voos K, et al. Discovery of a Potent Inhibitor Class with High Selectivity toward Clostridial Collagenases. J Am Chem Soc. 2017 Sep. 13; 139(36):12696-703) using batimastat as a positive control according to the guidelines of the manufacturer. |
| Affinity data for this assay | |
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