| Assay Method Information | |
| | Fragment Screening |
| Description: | Cocktails of 4-8 compounds were used for the initial screening with single compound soaks to verify the bound fragment identity and to rule out cooperative binding. Ligands or fragments, in dimethyl sulfoxide, were soaked into crystals (final concentration 10mM and 10% dimethyl sulfoxide) for 2 hours before flash freezing in liquid nitrogen. |
| Affinity data for this assay | |
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