| Assay Method Information | |
| | Kinase Activity Assay |
| Description: | TYK2 (the final concentration was 8 nM); ATP (the final concentration was 20 μM); ULight-labeled JAK-1 (Tyr1023) Peptide (the final concentration was 100 nM); the enzymatic reaction time was 2 hours. The maximum final concentration of compounds was 2.5 μM. After a 3-fold gradient dilution, 11 concentrations were obtained, with the minimum final concentration of 0.042 nM. The final DMSO concentration was 1%. |
| Affinity data for this assay | |
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