Compile Data Set for Download or QSAR
Report error Found 1219 for UniProtKB: B2RE45
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 552729BDBM552729(WO2022103411, Compound 52 | (2S,4R)-l-((S)-2-(4-cy...)
Affinity DataKd:  0.540nMAssay Description:Binding affinity to Navi-tagged VHL (unknown origin) assessed as dissociation constant by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50658072BDBM50658072(CHEMBL6120383)
Affinity DataIC50: 1.5nMAssay Description:Binding affinity to VHL (unknown origin) incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50658073BDBM50658073(CHEMBL6149323)
Affinity DataIC50: 2.10nMAssay Description:Binding affinity to VHL (unknown origin) incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 802067BDBM802067(methyl (S)-3-((2S,4R)-1-((S)- 5-acetyl-3-cycloprop...)
Affinity DataIC50: 2.30nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/2/2026
Entry Details
US Patent

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 552729BDBM552729(WO2022103411, Compound 52 | (2S,4R)-l-((S)-2-(4-cy...)
Affinity DataKd: <2.5nMAssay Description:Binding affinity to VHL (unknown origin)-NanoLuc fusion protein expressed in HEK293 cells assessed as apparent dissociation constant incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 552729BDBM552729(WO2022103411, Compound 52 | (2S,4R)-l-((S)-2-(4-cy...)
Affinity DataKd: <2.5nMAssay Description:Binding affinity to VHL (unknown origin)-NanoLuc fusion protein expressed in HEK293 cells assessed as apparent dissociation constant incubated for 2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50637018BDBM50637018(CHEMBL5568085)
Affinity DataKd: <2.5nMAssay Description:Binding affinity to VHL (unknown origin)-NanoLuc fusion protein expressed in HEK293 cells assessed as apparent dissociation constant incubated for 2 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50637018BDBM50637018(CHEMBL5568085)
Affinity DataKd:  2.80nMAssay Description:Binding affinity to VHL (unknown origin)-NanoLuc fusion protein expressed in HEK293 cells assessed as apparent dissociation constant incubated for 30...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 802074BDBM802074((2S,4R)-1-((S)-3-(3-(2-chloro- 3-hydroxyphenyl)pro...)
Affinity DataIC50: 2.84nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/2/2026
Entry Details
US Patent

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 552702BDBM552702((2S,4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-l...)
Affinity DataKd:  3.30nMAssay Description:Binding affinity to VHL (unknown origin)-NanoLuc fusion protein expressed in HEK293 cells assessed as apparent dissociation constant incubated for 2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50642739BDBM50642739(CHEMBL5575147)
Affinity DataKd:  3.40nMAssay Description:Binding affinity to VHL (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 552702BDBM552702((2S,4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-l...)
Affinity DataKd:  3.90nMAssay Description:Binding affinity to VHL (unknown origin)-NanoLuc fusion protein expressed in HEK293 cells assessed as apparent dissociation constant incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 552708BDBM552708((2S,4R)-l-((S)-2-cyclohexyl-2-(4-cyclopropyl-lH-l,...)
Affinity DataIC50: 5nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022103411

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 552729BDBM552729(WO2022103411, Compound 52 | (2S,4R)-l-((S)-2-(4-cy...)
Affinity DataIC50: 5nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022103411

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 552704BDBM552704((2S,4R)-l-((2S)-2-(adamantan-l-yl)-2-(4-cyclopropy...)
Affinity DataIC50: 5nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022103411

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 552703BDBM552703((2S,4R)-l-((S)-2-cyclohexyl-2-(4-cyclopropyl-lH-l,...)
Affinity DataIC50: 5nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022103411

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 552705BDBM552705((2S,4R)-l-((S)-2-(4-cyclopropyl-lH-l ,2,3-triazol-...)
Affinity DataIC50: 5nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022103411

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 802070BDBM802070(methyl (S)-3-((2S,4R)-1-((S)- 5-acetyl-3,7,7-trime...)
Affinity DataIC50: 5.30nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/2/2026
Entry Details
US Patent

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50658063BDBM50658063(CHEMBL6160814)
Affinity DataIC50: 6.20nMAssay Description:Binding affinity to VHL (unknown origin) incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 552686BDBM552686((2S,4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-l...)
Affinity DataKd:  6.30nMAssay Description:Binding affinity to VHL (unknown origin)-NanoLuc fusion protein expressed in HEK293 cells assessed as apparent dissociation constant incubated for 2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50658066BDBM50658066(CHEMBL6168026)
Affinity DataIC50: 6.40nMAssay Description:Binding affinity to VHL (unknown origin) incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 552686BDBM552686((2S,4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-l...)
Affinity DataKd:  6.5nMAssay Description:Binding affinity to VHL (unknown origin)-NanoLuc fusion protein expressed in HEK293 cells assessed as apparent dissociation constant incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 802058BDBM802058((2S,4R)-1-((S)-3-cyclopropyl- 7,7-dimethyl-7,8-dih...)
Affinity DataIC50: 7nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/2/2026
Entry Details
US Patent

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 454975BDBM454975(US10730870, Example 145)
Affinity DataKd:  7nMAssay Description:Binding affinity to NanoLuc-fused VHL (unknown origin) transfected in live HEK293 cells using NanoGlo as substrate assessed as dissociation constant ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 802060BDBM802060(tert-butyl (S)-8-((2S,4R)-4- hydroxy-2-(((S)-1-(4-...)
Affinity DataIC50: 7.5nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/2/2026
Entry Details
US Patent

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 454975BDBM454975(US10730870, Example 145)
Affinity DataIC50: 8nMAssay Description:Inhibition of NanoLuc-fused VHL (unknown origin) transfected in live HEK293 cells using NanoGlo as substrate incubated for 1 hrs by tracer based Nano...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 802063BDBM802063((2S,4R)-4-hydroxy-N-((S)-1- (4-(4-methylthiazol-5-...)
Affinity DataIC50: 8.40nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/2/2026
Entry Details
US Patent

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 802064BDBM802064((2S,4R)-1-((S)-5-acetyl-7,7- dimethyl-5,6,7,8-tetr...)
Affinity DataIC50: 8.40nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/2/2026
Entry Details
US Patent

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50658068BDBM50658068(CHEMBL6103145)
Affinity DataIC50: 8.60nMAssay Description:Binding affinity to VHL (unknown origin) incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 802071BDBM802071(ethyl (R)-8-((2S,4R)-4- hydroxy-2-(((S)-1-(4-(4- m...)
Affinity DataIC50: 8.60nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/2/2026
Entry Details
US Patent

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50658065BDBM50658065(CHEMBL6162491)
Affinity DataIC50: 9.30nMAssay Description:Binding affinity to VHL (unknown origin) incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 802066BDBM802066((2S,4R)-1-((S)-3-cyclopropyl- 7,7-dimethyl-5,6,7,8...)
Affinity DataIC50: 9.5nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/2/2026
Entry Details
US Patent

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 552726BDBM552726(WO2022103411, Compound 47 | (2S,4R)-l-((S)-2-(4-cy...)
Affinity DataIC50: 10nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022103411

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 552711BDBM552711((2S,4R)-l-((S)-3,3-dimethyl-2-(4-(l-methylcyclopro...)
Affinity DataIC50: 10nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022103411

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 454969BDBM454969(US10730870, Example 138 | US10730870, Example 145 ...)
Affinity DataKd:  10nMAssay Description:The surface plasmon resonance (SPR) experiments were conducted on a Biacore3000 (GE Healthcare). His-tagged VHL protein was immobilized on a carboxym...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2021
Entry Details
US Patent

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 552686BDBM552686((2S,4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-l...)
Affinity DataIC50: 10nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL / Elong...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022103411

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 552702BDBM552702((2S,4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-l...)
Affinity DataIC50: 10nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022103411

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 552731BDBM552731(WO2022103411, Compound 54 | (2S, 4R)-N-((S)-l-(2'-...)
Affinity DataIC50: 10nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022103411

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 552706BDBM552706((2S,4R)-N-(l-(2-chloro-4-(4-methylthia7,ol-5-yl)ph...)
Affinity DataIC50: 10nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022103411

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 552686BDBM552686((2S,4R)-l-((S)-2-(4-cyclopropyl-lH-l,2,3-triazol-l...)
Affinity DataIC50: 10nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2022
Entry Details
WIPO WO2022103411

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50404375BDBM50404375(CHEMBL5274307)
Affinity DataKd:  11nMAssay Description:Binding affinity to human VHL by isothermal calorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 802077BDBM802077(methyl (S)-3-((2S,4R)-1-((S)- 3-cyclopropyl-7,7-di...)
Affinity DataIC50: 11.1nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/2/2026
Entry Details
US Patent

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 802059BDBM802059(methyl (S)-3-((2S,4R)-1-((S)- 3-cyclopropyl-7,7-di...)
Affinity DataIC50: 11.6nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/2/2026
Entry Details
US Patent

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 802062BDBM802062((2S,4R)-1-((S)-7,7-dimethyl- 5,6,7,8-tetrahydro-4H...)
Affinity DataIC50: 14.9nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/2/2026
Entry Details
US Patent

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50658064BDBM50658064(CHEMBL6152304)
Affinity DataIC50: 15nMAssay Description:Binding affinity to VHL (unknown origin) incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50658067BDBM50658067(CHEMBL6170839)
Affinity DataIC50: 15nMAssay Description:Binding affinity to VHL (unknown origin) incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 802076BDBM802076(methyl (S)-3-((2S,4R)-4- hydroxy-1-((R)-3,7,7-trim...)
Affinity DataIC50: 15.5nMAssay Description:JAK1, JAK2, JAK3 and Tyk2 were purchased from Carna Biosciences, Inc. As the substrate, LANCE Ultra ULight-JAK1 Peptide (manufactured by PerkinElmer ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/2/2026
Entry Details
US Patent

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50658062BDBM50658062(CHEMBL6146804)
Affinity DataIC50: 16nMAssay Description:Binding affinity to VHL (unknown origin) incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50658201BDBM50658201(CHEMBL6148611)
Affinity DataIC50: 16nMAssay Description:Inhibition of VHL (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetVHL complex(Human)
Arvinas

US Patent
LigandChemical structure of BindingDB Monomer ID 454848BDBM454848(US10730870, Example 11 | US11512083, Example 11)
Affinity DataIC50: 16.3nMAssay Description:Ability of VHL ligands to compete for the HIF 1 a binding site on VCB was determined through a fluorescence polarization competition assay as describ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2023
Entry Details
US Patent

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