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Report error Found 374 of affinity data for UniProtKB/TrEMBL: D3DRH5
TargetProbable global transcription activator SNF2L2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50539801(CHEMBL4648912 | US11840533, Compound 70)
Affinity DataKd: <1nMAssay Description:Binding affinity to human partial length SMARCA2 (S1377 to Q1486 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetProbable global transcription activator SNF2L2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50642737(CHEMBL5564941)
Affinity DataIC50: 1.20nMAssay Description:Binding affinity to his-tagged BRM bromodomain (unknown origin) by alpha-LISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProbable global transcription activator SNF2L2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM394434(US10308614, Example 35 | 2-(6-amino-5-(pyrrolidin-)
Affinity DataKd:  2nMAssay Description:Binding affinity to SMARCA2 (unknown origin) assessed as dissociation constant by BROMOscan LeadHunter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetProbable global transcription activator SNF2L2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50642738(CHEMBL5571722)
Affinity DataIC50: 2.70nMAssay Description:Binding affinity to his-tagged BRM bromodomain (unknown origin) by alpha-LISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProbable global transcription activator SNF2L2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50628856(CHEMBL5412292)
Affinity DataKd:  3nMAssay Description:Binding affinity to SMARCA2 (unknown origin) assessed as dissociation constant by BROMOscan LeadHunter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM50469331(CHEMBL4282980 | US11958846, Example 6)
Affinity DataIC50: 5nMAssay Description:All subsequent reagent additions were performed using a MultiFlo FX Multi-Mode Dispenser. Assay buffer was 20 mM HEPES pH 7.5, 1 mM MgCl2, 20 mM KCl,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

LigandPNGBDBM50469330(CHEMBL4295096 | US11958846, Example 7)
Affinity DataIC50: 5nMAssay Description:All subsequent reagent additions were performed using a MultiFlo FX Multi-Mode Dispenser. Assay buffer was 20 mM HEPES pH 7.5, 1 mM MgCl2, 20 mM KCl,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

LigandPNGBDBM50469324(CHEMBL4286345 | US11958846, Example 4)
Affinity DataIC50: 5nMAssay Description:All subsequent reagent additions were performed using a MultiFlo FX Multi-Mode Dispenser. Assay buffer was 20 mM HEPES pH 7.5, 1 mM MgCl2, 20 mM KCl,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

TargetProbable global transcription activator SNF2L2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50469330(CHEMBL4295096 | US11958846, Example 7)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant His10-tagged ZZ-HCV3C-BRM ATPase-SnAC (636 to 1331 residues) (unknown origin) expressed in insect sf9 cells preincubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
LigandPNGBDBM50469320(CHEMBL4293567 | US11958846, Example 5)
Affinity DataIC50: 5nMAssay Description:All subsequent reagent additions were performed using a MultiFlo FX Multi-Mode Dispenser. Assay buffer was 20 mM HEPES pH 7.5, 1 mM MgCl2, 20 mM KCl,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

TargetProbable global transcription activator SNF2L2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50469329(CHEMBL4278436 | US11958846, Example 1)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant His10-tagged ZZ-HCV3C-BRM ATPase-SnAC (636 to 1331 residues) (unknown origin) expressed in insect sf9 cells preincubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetProbable global transcription activator SNF2L2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50469320(CHEMBL4293567 | US11958846, Example 5)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant His10-tagged ZZ-HCV3C-BRM ATPase-SnAC (636 to 1331 residues) (unknown origin) expressed in insect sf9 cells preincubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetProbable global transcription activator SNF2L2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50469324(CHEMBL4286345 | US11958846, Example 4)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant His10-tagged ZZ-HCV3C-BRM ATPase-SnAC (636 to 1331 residues) (unknown origin) expressed in insect sf9 cells preincubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetProbable global transcription activator SNF2L2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50469331(CHEMBL4282980 | US11958846, Example 6)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant His10-tagged ZZ-HCV3C-BRM ATPase-SnAC (636 to 1331 residues) (unknown origin) expressed in insect sf9 cells preincubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
LigandPNGBDBM50469329(CHEMBL4278436 | US11958846, Example 1)
Affinity DataIC50: 5nMAssay Description:All subsequent reagent additions were performed using a MultiFlo FX Multi-Mode Dispenser. Assay buffer was 20 mM HEPES pH 7.5, 1 mM MgCl2, 20 mM KCl,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

LigandPNGBDBM394585(US10308614, Example 188 | 2-(6-amino-5-(1-(1-)
Affinity DataIC50: 5.70nMAssay Description:Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvprgsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

LigandPNGBDBM394575(US10308614, Example 178 | 2-(6-amino-5-(2-)
Affinity DataIC50: 7.20nMAssay Description:Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvprgsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

LigandPNGBDBM394605(US10308614, Example 209 | 2-(6-amino-5-cyclohexylp...)
Affinity DataIC50: 8.80nMAssay Description:Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvprgsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

LigandPNGBDBM394584(US10308614, Example 187 | 2-(6-amino-5-(1-methyl-)
Affinity DataIC50: 10nMAssay Description:Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvprgsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

TargetProbable global transcription activator SNF2L2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM394584(US10308614, Example 187 | 2-(6-amino-5-(1-methyl-)
Affinity DataKd:  10nMAssay Description:Binding affinity to SMARCA2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetProbable global transcription activator SNF2L2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50469325(CHEMBL4294655 | US11958846, Example 3)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant His10-tagged ZZ-HCV3C-BRM ATPase-SnAC (636 to 1331 residues) (unknown origin) expressed in insect sf9 cells preincubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
LigandPNGBDBM50469325(CHEMBL4294655 | US11958846, Example 3)
Affinity DataIC50: 10nMAssay Description:All subsequent reagent additions were performed using a MultiFlo FX Multi-Mode Dispenser. Assay buffer was 20 mM HEPES pH 7.5, 1 mM MgCl2, 20 mM KCl,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

TargetProbable global transcription activator SNF2L2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50469329(CHEMBL4278436 | US11958846, Example 1)
Affinity DataKd:  13nMAssay Description:Binding affinity to N-terminal MBP-fused human BRM RecA domain (705 to 960 residues) expressed in Escherichia coli BL21 Star (DE3) by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetProbable global transcription activator SNF2L2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50628862(CHEMBL5409404)
Affinity DataKd:  13nMAssay Description:Binding affinity to SMARCA2 (unknown origin) assessed as dissociation constant by BROMOscan LeadHunter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM394567(US10308614, Example 170 | (S)-2-(6-amino-5-(1-)
Affinity DataIC50: 14.9nMAssay Description:Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvprgsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

TargetProbable global transcription activator SNF2L2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM394530(US10308614, Example 131 | (R)-1-(4-(3-amino-6-(2-)
Affinity DataKd:  16nMAssay Description:Binding affinity to human SMARCA2 (S1337 to Q1486 residues) expressed in bacterial expression system by bromoscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetProbable global transcription activator SNF2L2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50642736(CHEMBL5574201)
Affinity DataIC50: 18nMAssay Description:Binding affinity to his-tagged BRM bromodomain (unknown origin) by alpha-LISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProbable global transcription activator SNF2L2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50158688(CHEMBL3752911)
Affinity DataKd:  18nMAssay Description:Binding affinity to human SMARCA2 (S1337 to Q1486 residues) expressed in bacterial expression system by bromoscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM394528(US10308614, Example 129 | 1-(4-(3-amino-6-(2-)
Affinity DataIC50: 18.4nMAssay Description:Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvprgsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

LigandPNGBDBM394571(US10308614, Example 174 | 2-(6-amino-5-)
Affinity DataIC50: 19nMAssay Description:Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvprgsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

TargetProbable global transcription activator SNF2L2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50: 20nMAssay Description:Inhibition of SMARCA2 (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetProbable global transcription activator SNF2L2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM394405(US10308614, Example 6 | (S)-2-(6-amino-5-(2-)
Affinity DataKd:  20nMAssay Description:Binding affinity to SMARCA2 (unknown origin) assessed as dissociation constant by BROMOscan LeadHunter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetProbable global transcription activator SNF2L2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50628858(CHEMBL5401472)
Affinity DataKd:  20nMAssay Description:Binding affinity to SMARCA2 (unknown origin) assessed as dissociation constant by BROMOscan LeadHunter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetProbable global transcription activator SNF2L2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50628857(CHEMBL5398829)
Affinity DataKd:  20nMAssay Description:Binding affinity to SMARCA2 (unknown origin) assessed as dissociation constant by BROMOscan LeadHunter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM394403(US10308614, Example 5 | 2-(6-amino-5-(4-((dimethyl...)
Affinity DataIC50: 22.5nMAssay Description:Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvprgsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

TargetProbable global transcription activator SNF2L2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50628855(CHEMBL5411199)
Affinity DataKd:  24nMAssay Description:Binding affinity to SMARCA2 (unknown origin) assessed as dissociation constant by BROMOscan LeadHunter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM394606(US10308614, Example 210 | 2-(6-amino-5-)
Affinity DataIC50: 25nMAssay Description:Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvprgsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

TargetProbable global transcription activator SNF2L2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50628860(CHEMBL5406315)
Affinity DataKd:  30nMAssay Description:Binding affinity to SMARCA2 (unknown origin) assessed as dissociation constant by BROMOscan LeadHunter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetProbable global transcription activator SNF2L2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50628859(CHEMBL5425250)
Affinity DataKd:  32nMAssay Description:Binding affinity to SMARCA2 (unknown origin) assessed as dissociation constant by BROMOscan LeadHunter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
LigandPNGBDBM50469321(CHEMBL4286757 | US11958846, Example 2)
Affinity DataIC50: 33nMAssay Description:All subsequent reagent additions were performed using a MultiFlo FX Multi-Mode Dispenser. Assay buffer was 20 mM HEPES pH 7.5, 1 mM MgCl2, 20 mM KCl,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2024
Entry Details
US Patent

TargetProbable global transcription activator SNF2L2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50469321(CHEMBL4286757 | US11958846, Example 2)
Affinity DataIC50: 33nMAssay Description:Inhibition of recombinant His10-tagged ZZ-HCV3C-BRM ATPase-SnAC (636 to 1331 residues) (unknown origin) expressed in insect sf9 cells preincubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetProbable global transcription activator SNF2L2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM394399(US10308614, Example 1 | tert-butyl 4-(3-amino-6-(2...)
Affinity DataKd:  35nMAssay Description:Binding affinity to SMARCA2 (unknown origin) by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
LigandPNGBDBM394456(US10308614, Example 57 | 2-(6-amino-5-(3-)
Affinity DataIC50: 35.6nMAssay Description:Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvprgsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

LigandPNGBDBM394507(US10308614, Example 108 | 2-(6-amino-5-(3-methyl-4...)
Affinity DataIC50: 35.8nMAssay Description:Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvprgsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

LigandPNGBDBM394414(US10308614, Example 15 | 2-(6-amino-5-(4-(1-)
Affinity DataIC50: 36.1nMAssay Description:Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvprgsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

TargetProbable global transcription activator SNF2L2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50182279(CHEMBL3818070)
Affinity DataKd:  37nMAssay Description:Binding affinity to human SMARCA2 expressed in BL21 (DE3)-R3-BirA cells by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProbable global transcription activator SNF2L2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM394583(US10308614, Example 186 | 2-(6-amino-5-phenylpyrid...)
Affinity DataIC50: 37nMAssay Description:Inhibition of SMARCA2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
LigandPNGBDBM394583(US10308614, Example 186 | 2-(6-amino-5-phenylpyrid...)
Affinity DataIC50: 37.3nMAssay Description:Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvprgsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

LigandPNGBDBM394521(US10308614, Example 122 | 1-(4-(3-amino-6-(2-hydro...)
Affinity DataIC50: 39nMAssay Description:Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvprgsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

LigandPNGBDBM394614(US10308614, Example 218 | 2-(6-amino-5-(1-benzylpi...)
Affinity DataIC50: 39.3nMAssay Description:Histidine epitope tagged BRM (Isoform 2) Bromodomain1377-1486 (S1377-Q1486; Swiss Prot P51531-2; mhhhhhhgslvprgsSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

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