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Report error Found 191 for UniProtKB: O60741
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50419064BDBM50419064(CHEMBL1823874)
Affinity DataIC50: 15.8nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50419067BDBM50419067(CHEMBL1823878)
Affinity DataIC50: 31.6nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50419065BDBM50419065(CHEMBL1823875)
Affinity DataIC50: 31.6nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50419068BDBM50419068(CHEMBL1823879)
Affinity DataIC50: 50.1nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50419069BDBM50419069(CHEMBL1823880)
Affinity DataIC50: 79.4nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50419080BDBM50419080(CHEMBL1823677)
Affinity DataIC50: 126nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50419053BDBM50419053(ZD-7288 | CHEMBL2052019)
Affinity DataIC50: 158nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50419070BDBM50419070(CHEMBL1823881)
Affinity DataIC50: 200nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50419066BDBM50419066(CHEMBL1823876)
Affinity DataIC50: 251nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50419085BDBM50419085(CHEMBL1823887)
Affinity DataIC50: 316nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688533BDBM688533(US20240190854, Example 9)
Affinity DataIC50: 370nMAssay Description:PatchXpress 7000A Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50419055BDBM50419055(CHEMBL1823666)
Affinity DataIC50: 398nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50419074BDBM50419074(CHEMBL1823886)
Affinity DataIC50: 398nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50419062BDBM50419062(CHEMBL1435630)
Affinity DataIC50: 398nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50419083BDBM50419083(CHEMBL1823882)
Affinity DataIC50: 398nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688629BDBM688629(US20240190854, Example 125)
Affinity DataIC50: 400nMAssay Description:PatchXpress 7000A Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 688578BDBM688578(US20240190854, Example 73)
Affinity DataIC50: 500nMAssay Description:PatchXpress 7000A Solutions are used to record HCN currents.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
US Patent

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50419075BDBM50419075(CHEMBL1823888)
Affinity DataIC50: 631nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50419078BDBM50419078(CHEMBL1823667)
Affinity DataIC50: 631nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50419060BDBM50419060(CHEMBL1823674)
Affinity DataIC50: 631nMAssay Description:Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 639103BDBM639103(US20230391714, NUCC-0201991)
Affinity DataIC50: 740nMAssay Description:20 nM ofGST-tagged HCNlc40 protein (corresponding to the C terminal 40 amino acids of HCN1) was incubated with 200 nM of His-tagged TRIP8b(241-602) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 639104BDBM639104(US20230391714, NUCC-0201992)
Affinity DataIC50: 740nMAssay Description:20 nM ofGST-tagged HCNlc40 protein (corresponding to the C terminal 40 amino acids of HCN1) was incubated with 200 nM of His-tagged TRIP8b(241-602) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 639102BDBM639102(US20230391714, NUCC-0201990)
Affinity DataIC50: 740nMAssay Description:20 nM ofGST-tagged HCNlc40 protein (corresponding to the C terminal 40 amino acids of HCN1) was incubated with 200 nM of His-tagged TRIP8b(241-602) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 639111BDBM639111(US20230391714, NUCC-0201999)
Affinity DataIC50: 740nMAssay Description:20 nM ofGST-tagged HCNlc40 protein (corresponding to the C terminal 40 amino acids of HCN1) was incubated with 200 nM of His-tagged TRIP8b(241-602) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 639113BDBM639113(US20230391714, NUCC-0202001)
Affinity DataIC50: 740nMAssay Description:20 nM ofGST-tagged HCNlc40 protein (corresponding to the C terminal 40 amino acids of HCN1) was incubated with 200 nM of His-tagged TRIP8b(241-602) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 638832BDBM638832(US20230391714, NUCC-0201970)
Affinity DataIC50: 740nMAssay Description:20 nM ofGST-tagged HCNlc40 protein (corresponding to the C terminal 40 amino acids of HCN1) was incubated with 200 nM of His-tagged TRIP8b(241-602) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 639114BDBM639114(US20230391714, NUCC-0202002)
Affinity DataIC50: 740nMAssay Description:20 nM ofGST-tagged HCNlc40 protein (corresponding to the C terminal 40 amino acids of HCN1) was incubated with 200 nM of His-tagged TRIP8b(241-602) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 638818BDBM638818(US20230391714, NUCC-0201973 | US20230391714, NUCC-...)
Affinity DataIC50: 740nMAssay Description:20 nM ofGST-tagged HCNlc40 protein (corresponding to the C terminal 40 amino acids of HCN1) was incubated with 200 nM of His-tagged TRIP8b(241-602) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 639107BDBM639107(US20230391714, NUCC-0201995)
Affinity DataIC50: 740nMAssay Description:20 nM ofGST-tagged HCNlc40 protein (corresponding to the C terminal 40 amino acids of HCN1) was incubated with 200 nM of His-tagged TRIP8b(241-602) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 639109BDBM639109(US20230391714, NUCC-0201997)
Affinity DataIC50: 740nMAssay Description:20 nM ofGST-tagged HCNlc40 protein (corresponding to the C terminal 40 amino acids of HCN1) was incubated with 200 nM of His-tagged TRIP8b(241-602) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 639110BDBM639110(US20230391714, NUCC-0201998)
Affinity DataIC50: 740nMAssay Description:20 nM ofGST-tagged HCNlc40 protein (corresponding to the C terminal 40 amino acids of HCN1) was incubated with 200 nM of His-tagged TRIP8b(241-602) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 639151BDBM639151(US20230391714, NUCC-0202050)
Affinity DataIC50: 740nMAssay Description:20 nM ofGST-tagged HCNlc40 protein (corresponding to the C terminal 40 amino acids of HCN1) was incubated with 200 nM of His-tagged TRIP8b(241-602) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 639153BDBM639153(US20230391714, NUCC-0202054)
Affinity DataIC50: 740nMAssay Description:20 nM ofGST-tagged HCNlc40 protein (corresponding to the C terminal 40 amino acids of HCN1) was incubated with 200 nM of His-tagged TRIP8b(241-602) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 638847BDBM638847(US20230391714, NUCC-0201978)
Affinity DataIC50: 740nMAssay Description:20 nM ofGST-tagged HCNlc40 protein (corresponding to the C terminal 40 amino acids of HCN1) was incubated with 200 nM of His-tagged TRIP8b(241-602) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 639115BDBM639115(US20230391714, NUCC-0202003)
Affinity DataIC50: 740nMAssay Description:20 nM ofGST-tagged HCNlc40 protein (corresponding to the C terminal 40 amino acids of HCN1) was incubated with 200 nM of His-tagged TRIP8b(241-602) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 639148BDBM639148(US20230391714, NUCC-0202047)
Affinity DataIC50: 740nMAssay Description:20 nM ofGST-tagged HCNlc40 protein (corresponding to the C terminal 40 amino acids of HCN1) was incubated with 200 nM of His-tagged TRIP8b(241-602) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 639150BDBM639150(US20230391714, NUCC-0202049)
Affinity DataIC50: 740nMAssay Description:20 nM ofGST-tagged HCNlc40 protein (corresponding to the C terminal 40 amino acids of HCN1) was incubated with 200 nM of His-tagged TRIP8b(241-602) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 639129BDBM639129(US20230391714, NUCC-0202017)
Affinity DataIC50: 740nMAssay Description:20 nM ofGST-tagged HCNlc40 protein (corresponding to the C terminal 40 amino acids of HCN1) was incubated with 200 nM of His-tagged TRIP8b(241-602) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 638848BDBM638848(US20230391714, NUCC-0201979)
Affinity DataIC50: 740nMAssay Description:20 nM ofGST-tagged HCNlc40 protein (corresponding to the C terminal 40 amino acids of HCN1) was incubated with 200 nM of His-tagged TRIP8b(241-602) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 638850BDBM638850(US20230391714, NUCC-0201981)
Affinity DataIC50: 740nMAssay Description:20 nM ofGST-tagged HCNlc40 protein (corresponding to the C terminal 40 amino acids of HCN1) was incubated with 200 nM of His-tagged TRIP8b(241-602) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 639112BDBM639112(US20230391714, NUCC-0202000)
Affinity DataIC50: 760nMAssay Description:20 nM ofGST-tagged HCNlc40 protein (corresponding to the C terminal 40 amino acids of HCN1) was incubated with 200 nM of His-tagged TRIP8b(241-602) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 639128BDBM639128(US20230391714, NUCC-0202016)
Affinity DataIC50: 780nMAssay Description:20 nM ofGST-tagged HCNlc40 protein (corresponding to the C terminal 40 amino acids of HCN1) was incubated with 200 nM of His-tagged TRIP8b(241-602) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 639126BDBM639126(US20230391714, NUCC-0202014)
Affinity DataIC50: 810nMAssay Description:20 nM ofGST-tagged HCNlc40 protein (corresponding to the C terminal 40 amino acids of HCN1) was incubated with 200 nM of His-tagged TRIP8b(241-602) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 638844BDBM638844(US20230391714, NUCC-0201976)
Affinity DataIC50: 830nMAssay Description:20 nM ofGST-tagged HCNlc40 protein (corresponding to the C terminal 40 amino acids of HCN1) was incubated with 200 nM of His-tagged TRIP8b(241-602) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 639147BDBM639147(US20230391714, NUCC-0202046)
Affinity DataIC50: 840nMAssay Description:20 nM ofGST-tagged HCNlc40 protein (corresponding to the C terminal 40 amino acids of HCN1) was incubated with 200 nM of His-tagged TRIP8b(241-602) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 639140BDBM639140(US20230391714, NUCC-0202028)
Affinity DataIC50: 860nMAssay Description:20 nM ofGST-tagged HCNlc40 protein (corresponding to the C terminal 40 amino acids of HCN1) was incubated with 200 nM of His-tagged TRIP8b(241-602) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 638846BDBM638846(US20230391714, NUCC-0201977)
Affinity DataIC50: 870nMAssay Description:20 nM ofGST-tagged HCNlc40 protein (corresponding to the C terminal 40 amino acids of HCN1) was incubated with 200 nM of His-tagged TRIP8b(241-602) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 639116BDBM639116(US20230391714, NUCC-0202004)
Affinity DataIC50: 890nMAssay Description:20 nM ofGST-tagged HCNlc40 protein (corresponding to the C terminal 40 amino acids of HCN1) was incubated with 200 nM of His-tagged TRIP8b(241-602) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 639138BDBM639138(US20230391714, NUCC-0202026)
Affinity DataIC50: 910nMAssay Description:20 nM ofGST-tagged HCNlc40 protein (corresponding to the C terminal 40 amino acids of HCN1) was incubated with 200 nM of His-tagged TRIP8b(241-602) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 638852BDBM638852(US20230391714, NUCC-0201983)
Affinity DataIC50: 910nMAssay Description:20 nM ofGST-tagged HCNlc40 protein (corresponding to the C terminal 40 amino acids of HCN1) was incubated with 200 nM of His-tagged TRIP8b(241-602) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2024
Entry Details
US Patent

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