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TargetBromodomain-containing protein 4 [333-460](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205431((6S+2S)-PEG1 (7))
Affinity DataKi:  0.00430nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [44-168,333-460](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205431((6S+2S)-PEG1 (7))
Affinity DataKd:  0.00470nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [44-168,333-460](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205435((6S+2S)-PEG7 (11))
Affinity DataKd:  0.00590nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [44-168,333-460](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205434((6S+2S)-PEG4 (10))
Affinity DataKd:  0.00660nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [44-168,333-460](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205433((6S+2S)-PEG3 (9))
Affinity DataKd:  0.00750nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetIsoform C of Bromodomain-containing protein 4 (Short)(Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205431((6S+2S)-PEG1 (7))
Affinity DataKi:  0.00780nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [44-168,333-460](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205432((6S+2S)-PEG2 (8))
Affinity DataKd:  0.00910nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205431((6S+2S)-PEG1 (7))
Affinity DataKd:  0.0100nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [44-168,333-460](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205431((6S+2S)-PEG1 (7))
Affinity DataKi:  0.0120nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetIsoform C of Bromodomain-containing protein 4 (Short)(Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205431((6S+2S)-PEG1 (7))
Affinity DataKd:  0.0130nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205432((6S+2S)-PEG2 (8))
Affinity DataKd:  0.0140nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205434((6S+2S)-PEG4 (10))
Affinity DataKd:  0.0230nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [333-460](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205431((6S+2S)-PEG1 (7))
Affinity DataKd:  0.0240nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205435((6S+2S)-PEG7 (11))
Affinity DataKd:  0.0260nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205433((6S+2S)-PEG3 (9))
Affinity DataKd:  0.0290nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205430((6S+2S)-PEG0 (6))
Affinity DataKd:  0.0340nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [44-168,333-460](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205430((6S+2S)-PEG0 (6))
Affinity DataKd:  0.0470nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [333-460](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205453(MTI (35))
Affinity DataKi:  0.0530nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetIsoform C of Bromodomain-containing protein 4 (Short)(Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205453(MTI (35))
Affinity DataKi:  0.0620nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205438(6S+IBET-PEG2 (19))
Affinity DataKd:  0.0620nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [44-168,333-460](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205453(MTI (35))
Affinity DataKi:  0.0870nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50594436(CHEMBL5170488)
Affinity DataKd:  0.0950nMAssay Description:Inhibition of recombinant human BRD4-1 (44 to 168 residues) expressed in bacterial expression system by bromoscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205453(MTI (35))
Affinity DataKi:  0.0990nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50623611(CHEMBL5424952)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of BRD4 BD2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4 [349-460](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM684555(US12030880, Example 21)
Affinity DataIC50: 0.130nMAssay Description:In the present application, IC50 values of the compounds in inhibiting BRD4 (BD2) enzyme binding reaction were determined by homogeneous time resolve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2024
Entry Details
US Patent

TargetBromodomain-containing protein 4 [368-440](Human)
Poseidon Innovation 1

US Patent
LigandPNGBDBM684597(US20240226096, Example I-15 | 1-(3'-(5-(4-(tert- b...)
Affinity DataIC50: 0.152nMAssay Description:3x Complete Substrate plus Inhibitor Solution in Assay Medium (Opti-MEM I Reduced Serum Medium, no phenol red, and no serum) was prepared just before...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetBromodomain-containing protein 4 [368-440](Human)
Poseidon Innovation 1

US Patent
LigandPNGBDBM684583(US20240226096, Example I-2 | US20240226096, Exampl...)
Affinity DataIC50: 0.152nMAssay Description:3x Complete Substrate plus Inhibitor Solution in Assay Medium (Opti-MEM I Reduced Serum Medium, no phenol red, and no serum) was prepared just before...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetBromodomain-containing protein 4 [44-168](Human)
Dana-Farber Cancer Institute

LigandPNGBDBM205431((6S+2S)-PEG1 (7))
Affinity DataKi:  0.180nMAssay Description:Refer to DiscoverXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50623615(CHEMBL5432745)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of BRD4 BD2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50623606(CHEMBL5440537)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of BRD4 BD2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4 [349-460](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM223491(US9320741, JQ6 | US10407441, Compound JQ6 | US1092...)
Affinity DataIC50: 0.240nMAssay Description:The binding activity of lead compounds with the BRD4 site 2 was determined by Alpha-assay with a 12-point dose response curveMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2021
Entry Details
US Patent

TargetBromodomain-containing protein 4 [368-440](Human)
Poseidon Innovation 1

US Patent
LigandPNGBDBM223491(US9320741, JQ6 | US10407441, Compound JQ6 | US1092...)
Affinity DataIC50: 0.240nMAssay Description:All reagents were diluted in 50 mM HEPES, 100 mM NaCl, 0.1% BSA, pH 7.4 supplemented with 0.05% CHAPS and allowed to equilibrate to room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent

TargetBromodomain-containing protein 4(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM223491(US9320741, JQ6 | US10407441, Compound JQ6 | US1092...)
Affinity DataIC50: 0.240nMpH: 7.4 T: 2°CAssay Description:BRD4(2): Assays were performed as described previously with minor modifications from the manufacturer's protocol (PerkinElmer, USA). All reagents wer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2017
Entry Details
US Patent

TargetBromodomain-containing protein 4 [352-457](Human)
Abbvie

US Patent
LigandPNGBDBM220432(US9296741, 21)
Affinity DataKi:  0.25nM ΔG°:  -54.8kJ/molepH: 6.0 T: 2°CAssay Description:A time-resolved fluorescence resonance energy transfer (TR-FRET) assay was used to determine the affinities of compounds of the Examples listed in Ta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
US Patent

TargetBromodomain-containing protein 4 [349-460](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM684552(US12030880, Example 18)
Affinity DataIC50: 0.25nMAssay Description:In the present application, IC50 values of the compounds in inhibiting BRD4 (BD2) enzyme binding reaction were determined by homogeneous time resolve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2024
Entry Details
US Patent

TargetBromodomain-containing protein 4 [368-440](Human)
Poseidon Innovation 1

US Patent
LigandPNGBDBM661115(US20240101551, Compound of Formula I)
Affinity DataIC50: 0.25nMAssay Description:In the present application, the IC50 value of the compound of formula (I) in inhibiting BRD4 (BD1) enzyme binding reaction were determined by homogen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent

TargetBromodomain-containing protein 4 [349-460](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM684554(US12030880, Example 20)
Affinity DataIC50: 0.270nMAssay Description:In the present application, IC50 values of the compounds in inhibiting BRD4 (BD2) enzyme binding reaction were determined by homogeneous time resolve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2024
Entry Details
US Patent

TargetBromodomain-containing protein 4(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50594436(CHEMBL5170488)
Affinity DataKd:  0.290nMAssay Description:Binding affinity to BRD4-T (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50623607(CHEMBL5440963)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of BRD4 BD2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50623605(CHEMBL5401253)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of BRD4 BD2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4 [75-147](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575844(US11466005, Compound 16 | 6-(1,4-Dimethyl-1H-1,2,3...)
Affinity DataIC50: 0.300nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by Echo 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetBromodomain-containing protein 4(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50148603(CHEMBL3770724)
Affinity DataKd:  0.300nMAssay Description:Binding affinity to human partial length BRD4 BD2 expressed in bacterial expression system assessed as dissociation constant by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50594436(CHEMBL5170488)
Affinity DataKd:  0.320nMAssay Description:Inhibition of recombinant human BRD4-2 (333 to 460 residues) expressed in bacterial expression system by bromoscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetBromodomain-containing protein 4 [368-440](Human)
Poseidon Innovation 1

US Patent
LigandPNGBDBM684582(US20240226096, Example I-1 | 1-(3$#8243;-(4-(tert-...)
Affinity DataIC50: 0.323nMAssay Description:3x Complete Substrate plus Inhibitor Solution in Assay Medium (Opti-MEM I Reduced Serum Medium, no phenol red, and no serum) was prepared just before...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2024
Entry Details
US Patent

TargetBromodomain-containing protein 4(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50604593(CHEMBL5171062)
Affinity DataIC50: 0.330nMAssay Description:Inhibition of C-terminal His6-tagged BRD4 BD1 (unknown origin) using H-YSGRGK(Ac)GGK(Ac)GLGK(Ac)-GGAK(Ac)RHRK-Biotin-OH as substrate incubated for 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetBromodomain-containing protein 4 [75-147](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575868(US11466005, Compound 34 | 4-((6-(1,4-dimethyl-1H-1...)
Affinity DataIC50: 0.340nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by Echo 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetBromodomain-containing protein 4(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50604616(CHEMBL5206375)
Affinity DataIC50: 0.340nMAssay Description:Inhibition of C-terminal His6-tagged BRD4 BD2 (unknown origin) using H-YSGRGK(Ac)GGK(Ac)GLGK(Ac)-GGAK(Ac)RHRK-Biotin-OH as substrate incubated for 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetBromodomain-containing protein 4 [349-460](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM684542(US12030880, Example 7)
Affinity DataIC50: 0.340nMAssay Description:In the present application, IC50 values of the compounds in inhibiting BRD4 (BD2) enzyme binding reaction were determined by homogeneous time resolve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2024
Entry Details
US Patent

TargetBromodomain-containing protein 4 [349-460](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM684529(US12030880, Example 4)
Affinity DataIC50: 0.350nMAssay Description:In the present application, IC50 values of the compounds in inhibiting BRD4 (BD2) enzyme binding reaction were determined by homogeneous time resolve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2024
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575845(US11466005, Compound 2 | (S)-2-(6-(3,5-dimethyliso...)
Affinity DataIC50: 0.350nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by Echo 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

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