Compile Data Set for Download or QSAR
Report error Found 3406 of affinity data for UniProtKB/TrEMBL: P01111
TargetGTPase NRas(Human)
Massachusetts College of Pharmacy and Health Sciences University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50097071BDBM50097071(4-{5-[4-(3-Chloro-phenyl)-3-oxo-piperazin-1-ylmeth...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to NRAS (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetGTPase NRas(Human)
Massachusetts College of Pharmacy and Health Sciences University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 538632BDBM538632(NCGC 00371858 | US11254667, Compound I-38 | US115...)
Affinity DataIC50: 2nMAssay Description:AlphaScreen SureFire STAT5 (pTyr694;Tyr699) Assay kit (Perkin Elmer). Assay was performed according to manufacturer protocol.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2022
Entry Details
US Patent

TargetGTPase NRas(Human)
Massachusetts College of Pharmacy and Health Sciences University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 538632BDBM538632(NCGC 00371858 | US11254667, Compound I-38 | US115...)
Affinity DataIC50: 2nMAssay Description:Table 8-10: Compounds were tested in 10-dose IC50 mode with 3-fold serial dilution starting at 10 uM, and are relative to DMSO, the negative control....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 592031BDBM592031(US11566007, Example A711)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [Q61R](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 751132BDBM751132(US20250195521, Example A577)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 592041BDBM592041(US11566007, Example A721)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 592019BDBM592019(US11566007, Example A699)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 592027BDBM592027(US11566007, Example A707)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 592025BDBM592025(US11566007, Example A705)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 591568BDBM591568(US11566007, Example A246)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 751132BDBM751132(US20250195521, Example A577)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 591567BDBM591567(US11566007, Example A245)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 591566BDBM591566(US11566007, Example A244)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 591569BDBM591569(US11566007, Example A247)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 592047BDBM592047(US11566007, Example A727)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [Q61K](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 591709BDBM591709(US11566007, Example A388)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [Q61R](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 751151BDBM751151(US20250195521, Example A594)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 591794BDBM591794(US11566007, Example A474 | US11566007, Example A47...)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 591794BDBM591794(US11566007, Example A474 | US11566007, Example A47...)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 591799BDBM591799(US11566007, Example A479)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 592055BDBM592055(US11566007, Example A735 | Synthesis of 2-acryloyl...)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 750855BDBM750855(US20250195521, Example A325)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 750853BDBM750853(US20250195521, Example A323)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 591590BDBM591590(US11566007, Example A268)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 591588BDBM591588(US11566007, Example A266)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 751151BDBM751151(US20250195521, Example A594)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 591592BDBM591592(US11566007, Example A270)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas(Human)
Massachusetts College of Pharmacy and Health Sciences University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 751049BDBM751049(US20250195521, Example A501)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 591847BDBM591847(US11566007, Example A527)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 591849BDBM591849(US11566007, Example A529)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 591579BDBM591579(US11566007, Example A257)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 591577BDBM591577(US11566007, Example A255)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 751133BDBM751133(US20250195521, Example A578)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 591829BDBM591829(US11566007, Example A509)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 591871BDBM591871(US11566007, Example A551)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 591616BDBM591616(US11566007, Example A294)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 591870BDBM591870(US11566007, Example A550)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 591622BDBM591622(US11566007, Example A300)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 591876BDBM591876(US11566007, Example A556)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 591621BDBM591621(US11566007, Example A299)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 591620BDBM591620(US11566007, Example A298)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 591619BDBM591619(US11566007, Example A297)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 591854BDBM591854(US11566007, Example A534 | (2S)-2-((S)-7-(4-(dimet...)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 591856BDBM591856(US11566007, Example A536 | US11566007, Example A53...)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 591864BDBM591864(US11566007, Example A544)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 591863BDBM591863(US11566007, Example A543)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 591862BDBM591862(US11566007, Example A542 | The synthesis of 1-(4-(...)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 591614BDBM591614(US11566007, Example A292)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 591612BDBM591612(US11566007, Example A290)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 591417BDBM591417(US11566007, Example A95 | Synthesis of (2S)-N-[(8S...)
Affinity DataIC50: 10nMAssay Description:A variety of Ras proteins may be inhibited by compounds of the present invention (e.g., K-Ras, N-Ras, H-Ras, and mutants thereof at positions 12, 13 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

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