Compile Data Set for Download or QSAR
Report error Found 89 of affinity data for UniProtKB/TrEMBL: P01112
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50092365((R)-3-Benzyl-1-(3H-imidazol-4-ylmethyl)-4-(thiophe...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human H-rasMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50092365((R)-3-Benzyl-1-(3H-imidazol-4-ylmethyl)-4-(thiophe...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of HRAS (unknown origin) farnesylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50097071(4-{5-[4-(3-Chloro-phenyl)-3-oxo-piperazin-1-ylmeth...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity to HRAS (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50063453(1-[4-((S)-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclo...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of H-Ras (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50089967(5-{4-[Bis-(2-chloro-ethyl)-amino]-benzoylamino}-1H...)
Affinity DataIC50: 15nMAssay Description:Tested for 50% inhibition of generation of Human Ha-ras polymerase chain reaction(PCR) productsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50089960(5-{4-[Bis-(2-chloro-ethyl)-amino]-benzoylamino}-1H...)
Affinity DataIC50: 15nMAssay Description:Tested for 50% inhibition of generation of Human Ha-ras polymerase chain reaction(PCR) productsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50089961(5-{4-[Bis-(2-chloro-ethyl)-amino]-benzoylamino}-1-...)
Affinity DataIC50: 15nMAssay Description:Tested for 50% inhibition of generation of Human Ha-ras polymerase chain reaction(PCR) productsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50089969(5-[Bis-(2-chloro-ethyl)-amino]-benzofuran-2-carbox...)
Affinity DataIC50: 15nMAssay Description:Tested for 50% inhibition of generation of Human Ha-ras polymerase chain reaction(PCR) productsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50089962(5-{4-[Bis-(2-chloro-ethyl)-amino]-benzoylamino}-be...)
Affinity DataIC50: 15nMAssay Description:Tested for 50% inhibition of generation of Human Ha-ras polymerase chain reaction(PCR) productsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50089978(5-[Bis-(2-chloro-ethyl)-amino]-1H-indole-2-carboxy...)
Affinity DataIC50: 20nMAssay Description:Tested for 50% inhibition of generation of Human Ha-ras polymerase chain reaction(PCR) productsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50089971(5-[Bis-(2-chloro-ethyl)-amino]-1-methyl-1H-indole-...)
Affinity DataIC50: 20nMAssay Description:Tested for 50% inhibition of generation of Human Ha-ras polymerase chain reaction(PCR) productsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50520327(CHEMBL4456044)
Affinity DataKd:  51nMAssay Description:Inhibition GST-tagged recombinant HRAS G12V mutant (1 to 166 amino acids) (unknown origin) expressed in Escherichia coli C41(DE3) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50060139([(S)-1-((4-Benzyloxy-benzyl)-{[(1-phenyl-cyclobuty...)
Affinity DataIC50: 88nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50601398(CHEMBL5174384)
Affinity DataIC50: 100nMAssay Description:Inhibition of [35S]methionine labelled HRAS in rat Rat1 cells by immunoprecipitation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50601400(CHEMBL5171806)
Affinity DataIC50: 100nMAssay Description:Inhibition of HRAS (unknown origin) transfected in BALB/c nude mouse incubated for 3 days measured by immunoblot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50060141([(S)-1-{(4-Benzyloxy-benzyl)-[(2-methyl-2-phenyl-p...)
Affinity DataIC50: 180nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50060146([(S)-1-((4-Benzyloxy-benzyl)-{[(1-phenyl-cycloprop...)
Affinity DataIC50: 180nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50060140([(S)-1-{(4-Benzyloxy-benzyl)-[(2-cyano-2-phenyl-et...)
Affinity DataIC50: 190nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50055659(CHEMBL11252 | 2N-[5-(3-amino-3-iminopropylcarbamoy...)
Affinity DataIC50: 200nMAssay Description:Tested for 50% inhibition of generation of Human Ha-ras polymerase chain reaction(PCR) productsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50060145([(S)-1-{(4-Benzyloxy-benzyl)-[((S)-2-phenyl-propyl...)
Affinity DataIC50: 300nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50060138([(S)-1-{(4-Benzyloxy-benzyl)-[(2-phenyl-propylcarb...)
Affinity DataIC50: 310nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50060142([(S)-1-((4-Benzyloxy-benzyl)-{[(1-phenyl-cyclopent...)
Affinity DataIC50: 330nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50060149([(S)-1-{(4-Benzyloxy-benzyl)-[(2-phenyl-butylcarba...)
Affinity DataIC50: 400nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50060150([(S)-1-{(4-Benzyloxy-benzyl)-[((R)-2-phenyl-propyl...)
Affinity DataIC50: 570nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50060144([(S)-1-{(4-Benzyloxy-benzyl)-[((R)-1-methyl-2-phen...)
Affinity DataIC50: 710nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50060152([(S)-1-{(4-Benzyloxy-benzyl)-[(2-ethyl-2-phenyl-bu...)
Affinity DataIC50: 1.00E+3nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50060148([(S)-1-{(4-Benzyloxy-benzyl)-[(2-phenyl-pentylcarb...)
Affinity DataIC50: 1.00E+3nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50287960(1-[(2R,6S)-6-(tert-Butyl-dimethyl-silanyloxymethyl...)
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro for inhibition of nucleotide exchange process of oncogenic RasMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50287951(3-[(3aS,4R,6R,6aR)-6-(4-Chloro-6-methoxy-3-methyl-...)
Affinity DataIC50: 1.50E+3nMAssay Description:In vitro for inhibition of nucleotide exchange process of oncogenic RasMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50478506(Ophirapstanol Trisulfate)
Affinity DataIC50: 2.55E+3nMAssay Description:Inhibition of human recombinant p21RAS by GDPX assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50646348(CHEMBL5592316)
Affinity DataEC50:  2.60E+3nMAssay Description:Induction of Rluc8-tagged and GFP2-tagged H-Ras G12V mutant (unknown origin) disruption extracted from HEK293-EBNA cells assessed as intracellular H-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50287961((E)-5-[(2R,6R)-6-(4-Chloro-6-methoxy-3-methyl-pyra...)
Affinity DataIC50: 3.00E+3nMAssay Description:In vitro for inhibition of nucleotide exchange process of oncogenic RasMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50059857([(S)-1-[(4-Benzyloxy-benzyl)-(phenethylcarbamoyl-m...)
Affinity DataIC50: 4.30E+3nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50287943((E)-4-[(2R,6R)-6-(4-Chloro-6-methoxy-3-methyl-pyra...)
Affinity DataIC50: 4.70E+3nMAssay Description:In vitro for inhibition of nucleotide exchange process of oncogenic RasMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50249989(CHEMBL1387422)
Affinity DataEC50:  5.00E+3nMAssay Description:Induction of Rluc8-tagged and GFP2-tagged H-Ras G12V mutant (unknown origin) disruption extracted from HEK293-EBNA cells assessed as intracellular H-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50287946(1-[(2R,6S)-6-(tert-Butyl-dimethyl-silanyloxymethyl...)
Affinity DataIC50: 5.00E+3nMAssay Description:In vitro for inhibition of nucleotide exchange process of oncogenic RasMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50060143([(S)-1-{(4-Benzyloxy-benzyl)-[((S)-1-methyl-2-phen...)
Affinity DataIC50: 6.30E+3nMAssay Description:Concentration required to inhibit 50% of the cultured colonies of H-Ras-Fcells. More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50287963([(2S,6R)-6-(4-Chloro-6-methoxy-3-methyl-pyrazolo[3...)
Affinity DataIC50: 6.70E+3nMAssay Description:In vitro for inhibition of nucleotide exchange process of oncogenic RasMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50287959((E)-4-[(2R,6R)-6-(4-Chloro-6-methoxy-3-methyl-pyra...)
Affinity DataIC50: 7.00E+3nMAssay Description:In vitro for inhibition of nucleotide exchange process of oncogenic RasMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50287955((E)-4-[(2R,6R)-6-(4-Chloro-6-methoxy-3-methyl-pyra...)
Affinity DataIC50: 7.40E+3nMAssay Description:In vitro for inhibition of nucleotide exchange process of oncogenic RasMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50072339(Benzodiazepine-Distamycin Hybrid | CHEMBL102341)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of Ha-ras polymerase-chain reaction productMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50287958([(2S,6R)-6-(4-Chloro-6-methoxy-3-methyl-pyrazolo[3...)
Affinity DataIC50: 8.00E+3nMAssay Description:In vitro for inhibition of nucleotide exchange process of oncogenic RasMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM717666(US20250034173, Example 54)
Affinity DataKd: >1.00E+4nMAssay Description:Binding measurements were performed in parallel sets of either WT/G12D/G12C/G12V KRAS or WT K/H/N RAS proteins in GDP and/or GTPγS-loaded forms.Biaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM717638(US20250034173, Example 26)
Affinity DataKd: >1.00E+4nMAssay Description:Binding measurements were performed in parallel sets of either WT/G12D/G12C/G12V KRAS or WT K/H/N RAS proteins in GDP and/or GTPγS-loaded forms.Biaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM717613((General Method A): (8aS)-5-(6-chloro-5-cyclopropy...)
Affinity DataKd: >1.00E+4nMAssay Description:Binding measurements were performed in parallel sets of either WT/G12D/G12C/G12V KRAS or WT K/H/N RAS proteins in GDP and/or GTPγS-loaded forms.Biaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM717628(US20250034173, Example 16)
Affinity DataKd: >1.00E+4nMAssay Description:Binding measurements were performed in parallel sets of either WT/G12D/G12C/G12V KRAS or WT K/H/N RAS proteins in GDP and/or GTPγS-loaded forms.Biaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50287944((E)-3-[(2S,3S,4R,5R)-5-(4-Chloro-6-methoxy-3-methy...)
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro for inhibition of nucleotide exchange process of oncogenic RasMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM717640(US20250034173, Example 28)
Affinity DataKd: >1.00E+4nMAssay Description:Binding measurements were performed in parallel sets of either WT/G12D/G12C/G12V KRAS or WT K/H/N RAS proteins in GDP and/or GTPγS-loaded forms.Biaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM717667(US20250034173, Example 55)
Affinity DataKd: >1.00E+4nMAssay Description:Binding measurements were performed in parallel sets of either WT/G12D/G12C/G12V KRAS or WT K/H/N RAS proteins in GDP and/or GTPγS-loaded forms.Biaco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2025
Entry Details
US Patent

TargetGTPase HRas(Human)
Hefei University of Technology

Curated by ChEMBL
LigandPNGBDBM50287945(5-(4-chloro-6-methoxy-3-methyl-1H-pyrazolo[3,4-b]q...)
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro for inhibition of nucleotide exchange process of oncogenic RasMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

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