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TargetIntegrin alpha-L/beta-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107174(1-{3-[4-(2-Methoxy-phenylsulfanyl)-2,3-bis-trifluo...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of LFA-1 mediated JY-8 cell adhesion to ICAM-1, range(2-8)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50550223(CHEMBL4794300)
Affinity DataIC50: 0.390nMAssay Description:Antagonist activity at alphaLbeta2 in human Jurkat E6.1 cells assessed as reduction in cell adhesion to ICAM1 pre-incubated for 30 mins before ICAM1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107168(1-{3-[4-(2,3-Dihydro-benzo[1,4]dioxin-6-ylsulfanyl...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of LFA-1 mediated JY-8 cell adhesion to ICAM-1, range(0.03-0.5)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50074661((S)-1-{(S)-2-[(S)-3-Carboxy-2-((S)-4-methyl-2-{2-[...)
Affinity DataIC50: 0.840nMAssay Description:Antagonist activity at alphaLbeta2 in human Jurkat E6.1 cells assessed as reduction in cell adhesion to ICAM1 pre-incubated for 30 mins before ICAM1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50333919((S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
LigandPNGBDBM50333919((S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,...)
Affinity DataIC50: 1.20nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107166(1-{3-[3-Chloro-4-(2,3-dihydro-benzo[1,4]dioxin-6-y...)
Affinity DataIC50: 2nMAssay Description:Inhibition of LFA-1 mediated JY-8 cell adhesion to ICAM-1, range (2-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50386338(CHEMBL2048036)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50199036(4-[(5S,9R)-3-(3,5-dichloro-phenyl)-1-methyl-2,4-di...)
Affinity DataIC50: 3nMAssay Description:Inhibition of LFA1-mediated adhesion of T cell to HUVECMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
LigandPNGBDBM50386328(CHEMBL2048025)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107173(1-{3-[3-Chloro-4-(2-methoxy-phenylsulfanyl)-2-trif...)
Affinity DataIC50: 4nMAssay Description:Inhibition of LFA-1 mediated JY-8 cell adhesion to ICAM-1, range (2-9)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107176(1-{3-[2,3-Dichloro-4-(1-methyl-1H-indol-5-ylsulfan...)
Affinity DataIC50: 4nMAssay Description:Inhibition of LFA-1 mediated JY-8 cell adhesion to ICAM-1, range (1-10)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50386325(CHEMBL2048402)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50099130(1-[2-(2,3-Dichloro-4-{2-[3-(2-oxo-pyrrolidin-1-yl)...)
Affinity DataIC50: 5nMAssay Description:Ability to block the adherence of leukocyte function-associated antigen-1 (LFA-1) expressing JY-8 cells and intercellular adhesion molecule (ICAM-1) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107169(1-{3-[4-(1-Methyl-1H-indol-5-ylsulfanyl)-2,3-bis-t...)
Affinity DataIC50: 5nMAssay Description:Inhibition of LFA-1 mediated JY-8 cell adhesion to ICAM-1, range(3-10)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin beta-2/Intercellular adhesion molecule 1(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50324824((S)-2-(2-(benzofuran-2-carbonyl)-5,7-dichloro-1,2,...)
Affinity DataIC50: 5nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cells by cell migration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50324822((S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,...)
Affinity DataIC50: 5nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50333915((S)-2-(2-(benzofuran-2-carbonyl)-5,7-dichloro-1,2,...)
Affinity DataIC50: 5nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107162(3-[3-Chloro-4-(2-methoxy-phenylsulfanyl)-2-trifluo...)
Affinity DataIC50: 5nMAssay Description:Inhibition of LFA-1 mediated JY-8 cell adhesion to ICAM-1, range (3-10)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50099130(1-[2-(2,3-Dichloro-4-{2-[3-(2-oxo-pyrrolidin-1-yl)...)
Affinity DataIC50: 5nMAssay Description:Ability to block the adherence of leukocyte function-associated antigen-1 (LFA-1) expressing JY-8 cells and intercellular adhesion molecule (ICAM-1) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50199031(4-[(5S,9R)-3-(3,5-dichloro-phenyl)-1-methyl-2,4-di...)
Affinity DataIC50: 6nMAssay Description:Inhibition of LFA1-mediated adhesion of T cell to HUVECMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107164(3-[2,3-Dichloro-4-(2-methoxy-phenylsulfanyl)-pheny...)
Affinity DataIC50: 6nMAssay Description:Inhibition of LFA-1 mediated JY-8 cell adhesion to ICAM-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50099129(2-[2,3-Dichloro-4-(2-isopropyl-phenylsulfanyl)-phe...)
Affinity DataIC50: 6nMAssay Description:Ability to block the adherence of leukocyte function-associated antigen-1 (LFA-1) expressing JY-8 cells and intercellular adhesion molecule (ICAM-1) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50099129(2-[2,3-Dichloro-4-(2-isopropyl-phenylsulfanyl)-phe...)
Affinity DataIC50: 6nMAssay Description:Ability to block the adherence of leukocyte function-associated antigen-1 (LFA-1) expressing JY-8 cells and intercellular adhesion molecule (ICAM-1) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107167(1-{3-[2,3-Dichloro-4-(2,3-dihydro-benzo[1,4]dioxin...)
Affinity DataIC50: 6nMAssay Description:Inhibition of LFA-1 mediated JY-8 cell adhesion to ICAM-1, range (2-9)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50099134(1-{2-[2,3-Dichloro-4-(2-isopropyl-phenylsulfanyl)-...)
Affinity DataIC50: 6nMAssay Description:Ability to block the adherence of leukocyte function-associated antigen-1 (LFA-1) expressing JY-8 cells and intercellular adhesion molecule (ICAM-1) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50099134(1-{2-[2,3-Dichloro-4-(2-isopropyl-phenylsulfanyl)-...)
Affinity DataIC50: 6nMAssay Description:Ability to block the adherence of leukocyte function-associated antigen-1 (LFA-1) expressing JY-8 cells and intercellular adhesion molecule (ICAM-1) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107181(1-{3-[2,3-Dichloro-4-(2-isopropyl-phenylsulfanyl)-...)
Affinity DataIC50: 6nMAssay Description:Inhibition of LFA-1 mediated JY-8 cell adhesion to ICAM-1, range (3-18)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50386326(CHEMBL2048024)
Affinity DataIC50: 6nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50099132(4-({2-[2,3-Dichloro-4-(2-isopropyl-phenylsulfanyl)...)
Affinity DataIC50: 7nMAssay Description:Ability to block the adherence of leukocyte function-associated antigen-1 (LFA-1) expressing JY-8 cells and intercellular adhesion molecule (ICAM-1) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50099132(4-({2-[2,3-Dichloro-4-(2-isopropyl-phenylsulfanyl)...)
Affinity DataIC50: 7nMAssay Description:Ability to block the adherence of leukocyte function-associated antigen-1 (LFA-1) expressing JY-8 cells and intercellular adhesion molecule (ICAM-1) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50333917((S)-2-(5,7-dichloro-2-(pyrazolo[1,5-a]pyridine-2-c...)
Affinity DataIC50: 7nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107171(1-{3-[2,3-Dichloro-4-(2-methoxy-phenylsulfanyl)-ph...)
Affinity DataIC50: 8nMAssay Description:Inhibition of LFA-1 mediated JY-8 cell adhesion to ICAM-1, range (2-30)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50199037(4-[(5S,9R)-3-(3,5-dichloro-phenyl)-1-methyl-2,4-di...)
Affinity DataIC50: 8nMAssay Description:Inhibition of LFA1-mediated adhesion of T cell to HUVECMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107161(1-(4-Acetyl-piperazin-1-yl)-3-[2,3-dichloro-4-(2,3...)
Affinity DataIC50: 8nMAssay Description:Inhibition of LFA-1 mediated JY-8 cell adhesion to ICAM-1, range (6-10)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50154483((R)-3-(4-Bromo-benzyl)-1-(3,5-dichloro-phenyl)-5-(...)
Affinity DataKd:  8nMAssay Description:Dissociation constant for human Lymphocyte function associated antigen 1 in LFA-1/ICAM-1 binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin beta-2/Intercellular adhesion molecule 1(Human)
Sunesis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50324822((S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,...)
Affinity DataIC50: 9nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cells by cell migration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
LigandPNGBDBM50099135(1-{2-[2,3-Dichloro-4-(2-isopropyl-phenylsulfanyl)-...)
Affinity DataIC50: 9nMAssay Description:Ability to block the adherence of leukocyte function-associated antigen-1 (LFA-1) expressing JY-8 cells and intercellular adhesion molecule (ICAM-1) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50386331(CHEMBL2048028)
Affinity DataIC50: 9nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50154483((R)-3-(4-Bromo-benzyl)-1-(3,5-dichloro-phenyl)-5-(...)
Affinity DataKd:  9nMAssay Description:Dissociation constant for human Lymphocyte function-associated antigen-1 in LFA-1/ICAM-1 binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50099135(1-{2-[2,3-Dichloro-4-(2-isopropyl-phenylsulfanyl)-...)
Affinity DataIC50: 9nMAssay Description:Ability to block the adherence of leukocyte function-associated antigen-1 (LFA-1) expressing JY-8 cells and intercellular adhesion molecule (ICAM-1) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50386334(CHEMBL2048031)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50154476((R)-3-(4-Bromo-benzyl)-1-(3,5-dichloro-phenyl)-5-(...)
Affinity DataKd:  10nMAssay Description:Dissociation constant for human Lymphocyte function associated antigen1 in LFA-1/ICAM-1 binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50154489((R)-3-(4-Bromo-benzyl)-1-(3,5-dichloro-phenyl)-3-m...)
Affinity DataKd:  10nMAssay Description:Dissociation constant for human Lymphocyte function associated antigen 1 in LFA-1/ICAM-1 binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50386324(CHEMBL2048033)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
LigandPNGBDBM50386327(CHEMBL2048023)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50154481(Acetic acid 3-[(R)-5-(4-bromo-benzyl)-7-(3,5-dichl...)
Affinity DataKd:  10nMAssay Description:Dissociation constant for human Lymphocyte function associated antigen 1 in LFA-1/ICAM-1 binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50154506((R)-3-(4-Bromo-benzyl)-1-(3,5-dichloro-phenyl)-5-(...)
Affinity DataKd:  10nMAssay Description:Dissociation constant for human Lymphocyte function associated antigen 1 in LFA-1/ICAM-1 binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50386344(CHEMBL2048407)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetIntegrin alpha-L/beta-2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50154476((R)-3-(4-Bromo-benzyl)-1-(3,5-dichloro-phenyl)-5-(...)
Affinity DataKd:  10nMAssay Description:Dissociation constant for human Lymphocyte function associated antigen 1 in LFA-1/ICAM-1 binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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