Compile Data Set for Download or QSAR
Report error Found 79 for UniProtKB: P06748
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 625592BDBM625592(US20230322822, Compound 2)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of N-terminal GST-fused human NPM1-ALK (1 to 680 residues) extracted from baculovirus expression system using Srctide as substrate incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306682BDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human N-terminal GST-fused NPM1-ALK (1 to 680 residues) expressed in baculovirus expression system using Srctide as substrate measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50558033BDBM50558033(CHEMBL4762256)
Affinity DataIC50: 3nMAssay Description:Inhibition of NMP-ALK (unknown origin) expressed in human KARPAS-299 cells assessed as reduction in cell growthMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50558033BDBM50558033(CHEMBL4762256)
Affinity DataIC50: 6nMAssay Description:Inhibition of NMP-ALK (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 2 to 3 days by Bright-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 209865BDBM209865(ASP-3026 | 2-N-[2-methoxy-4-[4-(4-methylpiperazin-...)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of human N-terminal GST-fused NPM1-ALK (1 to 680 residues) expressed in baculovirus expression system using Srctide as substrate measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50558029BDBM50558029(CHEMBL4762861)
Affinity DataIC50: 7nMAssay Description:Inhibition of NMP-ALK (unknown origin) expressed in human KARPAS-299 cells assessed as reduction in cell growthMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetNucleophosmin(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50652792BDBM50652792(CHEMBL3752910)
Affinity DataKd:  8.30nMAssay Description:Binding affinity to human NPM1 incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetNucleophosmin(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50365463BDBM50365463(CHEMBL1232461)
Affinity DataIC50: 10nMAssay Description:Inhibition of NPM1 (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50558032BDBM50558032(CHEMBL4798141)
Affinity DataIC50: 13nMAssay Description:Inhibition of NMP-ALK (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 2 to 3 days by Bright-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 107057BDBM107057(US8592432, 34)
Affinity DataIC50: 20nMAssay Description:Inhibition of NMP-ALK (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 2 to 3 days by Bright-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 107057BDBM107057(US8592432, 34)
Affinity DataIC50: 26nMAssay Description:Inhibition of NMP-ALK (unknown origin) expressed in human KARPAS-299 cells assessed as reduction in cell growthMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50436850BDBM50436850(CHEMBL2403108 | CERITINIB | US10053458, Comparativ...)
Affinity DataIC50: 26nMAssay Description:Inhibition of NMP-ALK (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 2 to 3 days by Bright-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 107057BDBM107057(US8592432, 34)
Affinity DataIC50: 30nMAssay Description:Inhibition NMP-ALK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50558034BDBM50558034(CHEMBL4791252)
Affinity DataIC50: 33nMAssay Description:Inhibition of NMP-ALK (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 2 to 3 days by Bright-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50558029BDBM50558029(CHEMBL4762861)
Affinity DataIC50: 38nMAssay Description:Inhibition of NMP-ALK (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 2 to 3 days by Bright-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 107097BDBM107097(US8592432, 83)
Affinity DataIC50: 47nMAssay Description:Inhibition of NMP-ALK (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 2 to 3 days by Bright-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50558035BDBM50558035(CHEMBL4779222)
Affinity DataIC50: 47nMAssay Description:Inhibition of NMP-ALK (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 2 to 3 days by Bright-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50353048BDBM50353048(CHEMBL1822527)
Affinity DataIC50: 50nMAssay Description:Inhibition of NPM/ALK phosphorylation in human KARPAS299 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50306682BDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataIC50: 51nMAssay Description:Inhibition of NPM/ALK (unknown origin) transfected in mouse BAF3 cells assessed as cell growth inhibition after 72 hrs by [3H]-thymidine incorporatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50353046BDBM50353046(CHEMBL1822525)
Affinity DataIC50: 60nMAssay Description:Inhibition of NPM/ALK phosphorylation in human KARPAS299 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50158419BDBM50158419(CHEMBL3734798)
Affinity DataIC50: 64nMAssay Description:Inhibition of NMP-ALK (unknown origin) expressed in human KARPAS-299 cells assessed as reduction in cell growthMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50353044BDBM50353044(CHEMBL1822523)
Affinity DataIC50: 70nMAssay Description:Inhibition of NPM/ALK phosphorylation in human KARPAS299 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50353047BDBM50353047(CHEMBL1822526)
Affinity DataIC50: 80nMAssay Description:Inhibition of NPM/ALK phosphorylation in human KARPAS299 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50353042BDBM50353042(CHEMBL1822521)
Affinity DataIC50: 80nMAssay Description:Inhibition of NPM/ALK phosphorylation in human KARPAS299 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50353043BDBM50353043(CHEMBL1822522)
Affinity DataIC50: 85nMAssay Description:Inhibition of NPM/ALK phosphorylation in human KARPAS299 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50353041BDBM50353041(CHEMBL1822520)
Affinity DataIC50: 100nMAssay Description:Inhibition of NPM/ALK phosphorylation in human KARPAS299 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50353040BDBM50353040(CHEMBL1822519)
Affinity DataIC50: 100nMAssay Description:Inhibition of NPM/ALK phosphorylation in human KARPAS299 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50558028BDBM50558028(CHEMBL4755518)
Affinity DataIC50: 150nMAssay Description:Inhibition of NMP-ALK (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 2 to 3 days by Bright-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4552BDBM4552(CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...)
Affinity DataIC50: 150nMAssay Description:Inhibition of NPM/ALK L256T mutant kinase activity in BaF3 cells by radioenzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50158419BDBM50158419(CHEMBL3734798)
Affinity DataIC50: 151nMAssay Description:Inhibition of NMP-ALK (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 2 to 3 days by Bright-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50353045BDBM50353045(CHEMBL1822524)
Affinity DataIC50: 200nMAssay Description:Inhibition of NPM/ALK phosphorylation in human KARPAS299 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4552BDBM4552(CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...)
Affinity DataIC50: 200nMAssay Description:Inhibition of NPM/ALK L256T mutant autophosphorylation activity in BaF3 cells by antiphosphotyrosine immunoblotting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50558031BDBM50558031(CHEMBL4780490)
Affinity DataIC50: 328nMAssay Description:Inhibition of NMP-ALK (unknown origin) expressed in human KARPAS-299 cells assessed as reduction in cell growthMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50448037BDBM50448037(CHEMBL3115500)
Affinity DataIC50: 340nMAssay Description:Inhibition of NPM/ALK (unknown origin) transfected in mouse BAF3 cells assessed as cell growth inhibition after 72 hrs by [3H]-thymidine incorporatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575343BDBM50575343(CHEMBL4858720)
Affinity DataIC50: 370nMAssay Description:Inhibition of NPM-ALK (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hrs by cell prolife...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50558031BDBM50558031(CHEMBL4780490)
Affinity DataIC50: 684nMAssay Description:Inhibition of NMP-ALK (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 2 to 3 days by Bright-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50448048BDBM50448048(CHEMBL3115504)
Affinity DataIC50: 840nMAssay Description:Inhibition of NPM/ALK (unknown origin) transfected in mouse BAF3 cells assessed as cell growth inhibition after 72 hrs by [3H]-thymidine incorporatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50097956BDBM50097956(3-(4-Amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidi...)
Affinity DataIC50: 870nMAssay Description:Inhibition of NPM-ALK (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hrs by cell prolife...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50558025BDBM50558025(CHEMBL4749543)
Affinity DataIC50: 1.08E+3nMAssay Description:Inhibition of NMP-ALK (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 2 to 3 days by Bright-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50448035BDBM50448035(CHEMBL3115499)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of NPM/ALK (unknown origin) transfected in mouse BAF3 cells assessed as cell growth inhibition after 72 hrs by [3H]-thymidine incorporatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50558026BDBM50558026(CHEMBL4739938)
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibition of NMP-ALK (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 2 to 3 days by Bright-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50538508BDBM50538508(CHEMBL4634073)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of NPM/ALK (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-luc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50558024BDBM50558024(CHEMBL4762929)
Affinity DataIC50: 1.29E+3nMAssay Description:Inhibition of NMP-ALK (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 2 to 3 days by Bright-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50558030BDBM50558030(CHEMBL4756013)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of NMP-ALK (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 2 to 3 days by Bright-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50558022BDBM50558022(CHEMBL4795530)
Affinity DataIC50: 1.33E+3nMAssay Description:Inhibition of NMP-ALK (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 2 to 3 days by Bright-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50558024BDBM50558024(CHEMBL4762929)
Affinity DataIC50: 1.34E+3nMAssay Description:Inhibition of NMP-ALK (unknown origin) expressed in human KARPAS-299 cells assessed as reduction in cell growthMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50558027BDBM50558027(CHEMBL4787280)
Affinity DataIC50: 1.43E+3nMAssay Description:Inhibition of NMP-ALK (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 2 to 3 days by Bright-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetNucleophosmin(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50094238BDBM50094238(CHEMBL3589689)
Affinity DataEC50:  2.50E+3nMAssay Description:Inhibition of phosphorylated NPM1 recruitment to chromatic in 6 Gy irradiated human A549 cells assessed as extraction of pT199NPM1 pretreated 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 6568BDBM6568(PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of NPM/ALK L256T mutant kinase activity in BaF3 cells by radioenzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor)(Human)
Chengdu DIAO Pharmaceutical Group Co., Ltd.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50558026BDBM50558026(CHEMBL4739938)
Affinity DataIC50: 2.87E+3nMAssay Description:Inhibition of NMP-ALK (unknown origin) expressed in human KARPAS-299 cells assessed as reduction in cell growthMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
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