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TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50614466(CHEMBL5272537)
Affinity DataKi:  0.00400nMAssay Description:Binding affinity to angiotensin-converting enzyme (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50073120((4S,6S,9aS)-6-((S)-2-Mercapto-3-phenyl-propionylam...)
Affinity DataKi:  0.0150nMAssay Description:Inhibition of human fully glycosylated ACE N-terminal domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50073120((4S,6S,9aS)-6-((S)-2-Mercapto-3-phenyl-propionylam...)
Affinity DataKi:  0.0160nMAssay Description:Inhibition of human fully glycosylated ACE C-terminal domain expressed in CHO cells using Cbz-Phe-His-Leu as substrate preincubated for 15 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50272062((2S,5S)-1-((S)-3-mercapto-2-methylpropanoyl)-5-(3-...)
Affinity DataIC50: 0.0290nMAssay Description:Inhibition of ACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50367879(LISINOPRIL)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of angiotensin converting enzyme (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50367879(LISINOPRIL)
Affinity DataIC50: 0.100nMAssay Description:Inhibitory activity against Angiotensin I converting enzyme (ACE) from human blood serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50367879(LISINOPRIL)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human serum ACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50073120((4S,6S,9aS)-6-((S)-2-Mercapto-3-phenyl-propionylam...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of recombinant human ACE using Mca-BK2 as substrate preincubated for 10 mins followed by fluorogenic substrate addition and measured after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50175518((3R,7S)-7-((R)-2-Mercapto-3-phenyl-propionylamino)...)
Affinity DataIC50: 0.110nMAssay Description:Inhibitory concentration against angiotensin I converting enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50406389
Affinity DataIC50: 0.115nMAssay Description:Inhibitory activity against angiotensin converting enzyme (ACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM21642((2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolid...)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of human recombinant ACE by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2012
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50406391
Affinity DataIC50: 0.132nMAssay Description:Inhibitory activity against angiotensin converting enzyme (ACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50369460(CHEMBL1788109)
Affinity DataKi:  0.160nMAssay Description:Enzyme inhibitory activity towards Angiotensin I converting enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50272061((2S,5S)-1-((S)-3-mercapto-2-methylpropanoyl)-5-(ph...)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of ACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNeprilysin/Angiotensin-converting enzyme(Human)
Theravance Biopharma R&D Ip

US Patent
LigandPNGBDBM298285(US11547687, Example 2A | US11547687, Compound Exam...)
Affinity DataKi:  0.200nMAssay Description:The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
US Patent

TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50406942(CHEMBL80665)
Affinity DataIC50: 0.229nMAssay Description:Inhibitory activity against angiotensin converting enzyme (ACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50406908(CHEMBL78629)
Affinity DataIC50: 0.251nMAssay Description:Inhibitory activity against angiotensin converting enzyme (ACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50406375(CHEMBL35682)
Affinity DataIC50: 0.288nMAssay Description:Inhibitory activity against angiotensin converting enzyme (ACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50406392
Affinity DataIC50: 0.295nMAssay Description:Inhibitory activity against angiotensin converting enzyme (ACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50406380(CHEMBL284734)
Affinity DataIC50: 0.295nMAssay Description:Inhibitory activity against angiotensin converting enzyme (ACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetNeprilysin/Angiotensin-converting enzyme(Human)
Theravance Biopharma R&D Ip

US Patent
LigandPNGBDBM582848(US11547687, Comparative Compound J | US20230285340...)
Affinity DataKi:  0.316nMAssay Description:The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
US Patent

TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50084629(1-(3-Benzoylsulfanyl-2-methyl-propionyl)-4-phenyls...)
Affinity DataIC50: 0.400nMAssay Description:Inhibitory activity against angiotensin I converting enzyme (ACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50303321((2S)-2-({3-[Hydroxyl(2-phenyl-(1R)-1-{[(benzyloxy)...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of human somatic ACE C-terminal domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50303319((S)-2-[(S)-3-[((R)-1-Benzyloxycarbonylamino-2-phen...)
Affinity DataKi:  0.410nMAssay Description:Inhibition of human somatic ACE C-terminal domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50406394
Affinity DataIC50: 0.490nMAssay Description:Inhibitory activity against angiotensin converting enzyme (ACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50017125(CHEMBL295690 | 1-[6-Amino-2-(1-carboxy-3-phenyl-pr...)
Affinity DataIC50: 0.5nMAssay Description:Compound tested in vitro for inhibition of Angiotensin I converting enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50367249(CHEMBL309601)
Affinity DataKi:  0.5nMAssay Description:Compound was evaluated for the inhibition of Angiotensin I converting enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMed
TargetNeprilysin/Angiotensin-converting enzyme(Human)
Theravance Biopharma R&D Ip

US Patent
LigandPNGBDBM582849(US11547687, Comparative Compound K)
Affinity DataKi:  0.501nMAssay Description:The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
US Patent

TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50406370(CHEMBL34832)
Affinity DataIC50: 0.525nMAssay Description:Inhibitory activity against angiotensin converting enzyme (ACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50406369(CHEMBL289022)
Affinity DataIC50: 0.525nMAssay Description:Inhibitory activity against angiotensin converting enzyme (ACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50121930(6-(1-Carboxy-3-phenyl-propylamino)-5-oxo-octahydro...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of Angiotensin I converting enzyme (ACE) in Bothrops jararaca venomMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50121930(6-(1-Carboxy-3-phenyl-propylamino)-5-oxo-octahydro...)
Affinity DataIC50: 0.603nMAssay Description:Inhibitory activity against angiotensin converting enzyme (ACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50406384(CHEMBL34650)
Affinity DataIC50: 0.631nMAssay Description:Inhibitory activity against angiotensin converting enzyme (ACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetNeprilysin/Angiotensin-converting enzyme(Human)
Theravance Biopharma R&D Ip

US Patent
LigandPNGBDBM298305(US11547687, Compound Example 5A | US10123984, Exam...)
Affinity DataKi:  0.631nMAssay Description:The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
US Patent

TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50303320((S)-2-[(R)-3-[((R)-1-Benzyloxycarbonylamino-2-phen...)
Affinity DataKi:  0.650nMAssay Description:Inhibition of human ACE C-terminal domain expressed in CHO cells after 90 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50303320((S)-2-[(R)-3-[((R)-1-Benzyloxycarbonylamino-2-phen...)
Affinity DataKi:  0.650nMAssay Description:Inhibition of human somatic ACE C-terminal domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50303320((S)-2-[(R)-3-[((R)-1-Benzyloxycarbonylamino-2-phen...)
Affinity DataKi:  0.680nMAssay Description:Inhibition of human somatic ACE in presence of bufferMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50520683(CHEMBL4476621)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human recombinant ACE using Abz-FRK(Dnp)-P-OH as substrate after 30 mins by fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50406378(CHEMBL431707)
Affinity DataIC50: 0.776nMAssay Description:Inhibitory activity against angiotensin converting enzyme (ACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50406942(CHEMBL80665)
Affinity DataIC50: 0.794nMAssay Description:Inhibition of angiotensin I converting enzyme in silicoMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50017122(7-[2-(1-Carboxy-3-phenyl-propylamino)-propionyl]-1...)
Affinity DataIC50: 0.800nMAssay Description:Compound tested in vitro for inhibition of Angiotensin I converting enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50406372(CHEMBL33025)
Affinity DataIC50: 0.871nMAssay Description:Inhibitory activity against angiotensin converting enzyme (ACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50406373(CHEMBL284843)
Affinity DataIC50: 0.891nMAssay Description:Inhibitory activity against angiotensin converting enzyme (ACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50272145((2S,5S)-1-((S)-3-Mercapto-2-methyl-propionyl)-5-(3...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of ACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Human)
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50369775(Mavik | RU-44570 | TRANDOLAPRIL)
Affinity DataIC50: 0.930nMAssay Description:Inhibitory activity against angiotensin I converting enzyme (ACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetNeprilysin/Angiotensin-converting enzyme(Human)
Theravance Biopharma R&D Ip

US Patent
LigandPNGBDBM298304(US10123984, Example 5-17 | US20230285340, Example ...)
Affinity DataKi: <1nMAssay Description:Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetNeprilysin/Angiotensin-converting enzyme(Human)
Theravance Biopharma R&D Ip

US Patent
LigandPNGBDBM298305(US11547687, Compound Example 5A | US10123984, Exam...)
Affinity DataKi: <1nMAssay Description:Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetNeprilysin/Angiotensin-converting enzyme(Human)
Theravance Biopharma R&D Ip

US Patent
LigandPNGBDBM458409(US10744104, Example 7B | US11547687, Example 8-3 |...)
Affinity DataKi: <1nMAssay Description:Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetNeprilysin/Angiotensin-converting enzyme(Human)
Theravance Biopharma R&D Ip

US Patent
LigandPNGBDBM298307(US10123984, Example 8-2 | US10744104, Example 8-2 ...)
Affinity DataKi: <1nMAssay Description:Recombinant human NEP and recombinant human ACE were obtained commercially (R&D Systems, Minneapolis, Minn., catalog numbers 1182-ZN and 929-ZN, resp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetNeprilysin/Angiotensin-converting enzyme(Human)
Theravance Biopharma R&D Ip

US Patent
LigandPNGBDBM582645(US11547687, Example 5-13)
Affinity DataKi: <1nMAssay Description:The assays were performed in 384-well white opaque plates at 37° C. using the fluorogenic peptide substrates at a concentration of 10 μM in Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
US Patent

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