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TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM28123(CHEMBL318804 | 4-({3-chloro-4-[(1-methyl-1H-imidaz...)
Affinity DataIC50: 0.0100nMAssay Description:Inhibit ion of MAPK phosphorylation in LoVo cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50331095(Tivozanib | CHEMBL1289494 | US10464902, Tivozanib)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of ERK1 phosphorylation in VEGF-stimulated serum-starved human HUVEC cells by immunoblotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50094465(CHEMBL3590106 | US10525036, Example BVD-523 | US10...)
Affinity DataKi: <0.300nMAssay Description:Binding affinity to ERK1 (unknown origin) measured after 20 mins in presence of [gamma33P]ATP by scintillation counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50325534(nalfurafine | CHEMBL267495)
Affinity DataEC50:  0.550nMAssay Description:Inhibition of ERK1 phosphorylation (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50601918(TEMUTERKIB | Temuterkib | Ly 3214996 | Ly3214996 |...)
Affinity DataKi:  0.650nMAssay Description:Binding affinity to ERK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM120095(US8697715, 39 | US9259470, 39 | US10525036, Exampl...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM696313(US20240300975, Compound WX001)
Affinity DataIC50: 1.20nMAssay Description:1. Purpose of the Assay:The ability of compounds to inhibit ERK1 and ERK2 kinase activity was measured.2. Assay Buffer:20 mM Hepes (pH 7.5), 10 mM Mg...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/8/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM697147(US20240309018, Compound WX001)
Affinity DataIC50: 1.40nMAssay Description:1. Purpose of the Assay:The ability of the compound to inhibit ERK1 and ERK2 kinase activity was measured.2. Assay Buffer:20 mM Hepes (pH 7.5), 10 mM...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
1/16/2025
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50531622(CHEMBL4434915)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of ERK1 (unknown origin) using lipid as substrate after 40 mins by ADP-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50505988(CHEMBL4482864)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of ERK1/2 in human A375 cells assessed as inhibition of ERK phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50601920(Asn007 | Asn007 rd | ASN007)
Affinity DataIC50: 2nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50456348(CHEMBL4212211 | US11001575, Example 683)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of ERK1/2 phosphorylation in human A375 cells harboring BRAF V600E mutant after 4 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50094464(CHEMBL3590107 | US10525036, Example SCH772984 | US...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of ERK1/2 in human A375 cells assessed as inhibition of ERK phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM120086(US8697715, 1 | US9259470, 1)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM120086(US8697715, 1 | US9259470, 1)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50586289(CHEMBL5070887)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of ERK1 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50531640(CHEMBL4588783)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of ERK1 (unknown origin) using lipid as substrate after 40 mins by ADP-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50505994(CHEMBL4440109)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of ERK1/2 in human A375 cells assessed as inhibition of ERK phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50456348(CHEMBL4212211 | US11001575, Example 683)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of ERK1/2 in human A375 cells harboring BRAF V600E mutant assessed as suppression of RSK phosphorylation after 4 hrs by MSD assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50531627(CHEMBL4567212)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of ERK1 (unknown origin) using lipid as substrate after 40 mins by ADP-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50532351(CHEMBL4565958)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50532351(CHEMBL4565958)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50532350(CHEMBL4571067)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50532350(CHEMBL4571067)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50094464(CHEMBL3590107 | US10525036, Example SCH772984 | US...)
Affinity DataIC50: 4nMAssay Description:Inhibition of ERK1 (unknown origin) after 45 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50094464(CHEMBL3590107 | US10525036, Example SCH772984 | US...)
Affinity DataIC50: 4nMAssay Description:Inhibition of ERK1 (unknown origin) incubated for 45 mins in presence of ATP by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50531628(CHEMBL4532652)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of ERK1 (unknown origin) using lipid as substrate after 40 mins by ADP-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50505992(CHEMBL4452853)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of ERK1/2 in human A375 cells assessed as inhibition of ERK phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50532362(CHEMBL4436718)
Affinity DataIC50: 5nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50532362(CHEMBL4436718)
Affinity DataIC50: 5nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50601918(TEMUTERKIB | Temuterkib | Ly 3214996 | Ly3214996 |...)
Affinity DataIC50: 5nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50505988(CHEMBL4482864)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of ERK1/2 in human A375 cells assessed as inhibition of RSK phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM120095(US8697715, 39 | US9259470, 39 | US10525036, Exampl...)
Affinity DataIC50: 6.10nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM120095(US8697715, 39 | US9259470, 39 | US10525036, Exampl...)
Affinity DataIC50: 6.10nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM570913(US11440904, Compound 11)
Affinity DataIC50: 6.23nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50532361(CHEMBL4435650)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50532361(CHEMBL4435650)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50458811(CHEMBL4209570)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of ERK1 (unknown origin) using peptide substrate measured after 45 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50094464(CHEMBL3590107 | US10525036, Example SCH772984 | US...)
Affinity DataIC50: 8nMAssay Description:Inhibition of ERK1 (unknown origin) using peptide substrate measured after 45 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM103302(SCH772984 | US8546404, 6)
Affinity DataIC50: 8.30nMAssay Description:The IC50 values of selected kinases were determined using either Z'LYTE, Adapta or LanthaScreen assays.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2014
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50505990(CHEMBL4458562)
Affinity DataIC50: 9.10nMAssay Description:Inhibition of ERK1/2 in human A375 cells assessed as inhibition of ERK phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human ERK1 using myelin basic protein as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50505991(CHEMBL4470113)
Affinity DataIC50: 10nMAssay Description:Inhibition of ERK1/2 in human A375 cells assessed as inhibition of RSK phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM351000(US9796700, Compound I-90)
Affinity DataIC50: 10nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM318045(US9624228, Example 1 | US10301317, Example 1)
Affinity DataIC50: 10nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50505992(CHEMBL4452853)
Affinity DataIC50: 12nMAssay Description:Inhibition of ERK1/2 in human A375 cells assessed as inhibition of RSK phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50265959(CHEMBL4071576)
Affinity DataIC50: 12nMAssay Description:Inhibition of ERK1/2 in human A375 cells assessed as inhibition of ERK phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50094464(CHEMBL3590107 | US10525036, Example SCH772984 | US...)
Affinity DataIC50: 12nMAssay Description:Inhibition of ERK1/2 in human A375 cells assessed as inhibition of RSK phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM206343(US9259470, 167)
Affinity DataIC50: 13nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Kirin Brewery, Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM206343(US9259470, 167)
Affinity DataIC50: 13nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
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