Compile Data Set for Download or QSAR
Report error Found 417 of affinity data for UniProtKB/TrEMBL: P28593
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50093208(2-(5-Bromo-1H-indol-3-yl)-N-[3-(4-{3-[2-(5-bromo-1...)
Affinity DataKi:  76nMAssay Description:The compound was evaluated for inhibition of trypanothione reductase enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50240622(N1,N2-bis(dihydrocaffeoyl)spermine | 3-(3,4-Dihydr...)
Affinity DataKi:  76nMAssay Description:The compound was evaluated for inhibition of trypanothione reductase enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50091160([3-(2-Chloro-phenothiazin-10-yl)-propyl]-(3,4-dich...)
Affinity DataKi:  120nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50178811(N-(3-aminopropyl)-4-tert-butyl-N,N-dimethylbenzena...)
Affinity DataKi:  150nMAssay Description:Mixed inhibition of trypanothione reductase from Trypanosoma cruzi using TSST substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50096495(N-{3-[Bis-(3-phenyl-propyl)-amino]-propyl}-N,N'-bi...)
Affinity DataKi:  151nMAssay Description:Tested for binding affinity against trypanothione reductase from Trypanosoma cruziMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50178803(3,4-dichloro-N-(3-(2-chloro-10H-phenothiazin-10-yl...)
Affinity DataKi:  180nMAssay Description:Linear competitive inhibition of trypanothione reductase from Trypanosoma cruzi using TSST substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50615386(CHEMBL5283195)
Affinity DataIC50: 200nMAssay Description:Inhibition of Trypanosoma cruzi TryRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50103373(CHEMBL3398189)
Affinity DataKi:  255nMAssay Description:Inhibition of Trypanosoma cruzi trypanothione reductase assessed as reduction of trypanothione disulfide by spectrophotometricallyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2016
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50093209(2-(5-Methoxy-1H-indol-3-yl)-N-[3-(4-{3-[2-(5-metho...)
Affinity DataKi:  280nMAssay Description:The compound was evaluated for inhibition of trypanothione reductase enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50087158(5-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50: 300nMAssay Description:Concentration required for inhibition of Trypanothione reductase (TcTR) from Trypanosoma cruzi in the presence of 50 uM TS2 as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50093210(3-(1H-Indol-3-yl)-N-(3-{4-[3-(2-1H-indol-3-yl-acet...)
Affinity DataKi:  350nMAssay Description:The compound was evaluated for inhibition of trypanothione reductase enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50093205(2-(1H-Indol-3-yl)-N-(3-{4-[3-(2-1H-indol-3-yl-acet...)
Affinity DataKi:  390nMAssay Description:The compound was evaluated for inhibition of trypanothione reductase enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM10469(CHEMBL424707 | Bis-THA inhibitor 8 | N-[9-(1,2,3,4...)
Affinity DataKi:  400nMAssay Description:Competitive inhibition of Trypanosoma cruzi trypanothione reductase using varying levels of trypanothione disulfide as substrate by Lineweaver--burk ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2020
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50178803(3,4-dichloro-N-(3-(2-chloro-10H-phenothiazin-10-yl...)
Affinity DataKi:  440nMAssay Description:Mixed inhibition of trypanothione reductase from Trypanosoma cruzi using TSST substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50087157(5-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50: 450nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 uM T(S)2.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50091158([3-(2-Chloro-phenothiazin-10-yl)-propyl]-(3,4-dime...)
Affinity DataKi:  470nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50091165((4-Benzyloxy-benzyl)-[3-(2-chloro-phenothiazin-10-...)
Affinity DataKi:  470nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50087157(5-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50: 500nMAssay Description:Concentration required for inhibition of Trypanothione reductase (TcTR) from Trypanosoma cruzi in the presence of 50 uM TS2 as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50070270(Pentanedioic acid bis-[(3-{4-bromo-2-[3-(4-methyl-...)
Affinity DataIC50: 550nMAssay Description:Inhibition of Trypanosoma cruzi TryRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50070270(Pentanedioic acid bis-[(3-{4-bromo-2-[3-(4-methyl-...)
Affinity DataIC50: 550nMAssay Description:Inhibition of trypanothione reductase from Trypanosoma cruzi, in the presence 57 uM of trypanothione T(SH)2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50091148([3-(2-Chloro-phenothiazin-10-yl)-propyl]-(7-methox...)
Affinity DataKi:  560nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50178809(4-tert-butyl-N-(3-(2-chloro-10H-phenothiazin-10-yl...)
Affinity DataKi:  570nMAssay Description:Linear competitive inhibition of trypanothione reductase from Trypanosoma cruzi using TSST substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50087156(5-{3-[4-(3-Dibutylamino-propylcarbamoyl)-butyl]-8-...)
Affinity DataIC50: 600nMAssay Description:Concentration required for inhibition of Trypanothione reductase (TcTR) from Trypanosoma cruzi in the presence of 50 uM TS2 as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50178811(N-(3-aminopropyl)-4-tert-butyl-N,N-dimethylbenzena...)
Affinity DataIC50: 600nMAssay Description:Inhibitory activity against trypanothione reductase from Trypanosoma cruzi using 0.12 mM TSST substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50615388(CHEMBL5280255)
Affinity DataIC50: 600nMAssay Description:Inhibition of Trypanosoma cruzi TryRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50096500(N,N'-Bis-(3-phenyl-propyl)-N,N'-bis-[3-(3-phenyl-p...)
Affinity DataKi:  614nMAssay Description:Tested for binding affinity against trypanothione reductase from Trypanosoma cruziMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50091162((4-tert-Butyl-benzyl)-[3-(2-chloro-phenothiazin-10...)
Affinity DataKi:  680nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50091163(Benzhydryl-[3-(2-chloro-phenothiazin-10-yl)-propyl...)
Affinity DataKi:  710nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50093206(Spermine derivative | CHEMBL78036)
Affinity DataKi:  750nMAssay Description:The compound was evaluated for inhibition of trypanothione reductase enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50091154([3-(2-Chloro-phenothiazin-10-yl)-propyl]-(3,5-dime...)
Affinity DataKi:  770nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50091160([3-(2-Chloro-phenothiazin-10-yl)-propyl]-(3,4-dich...)
Affinity DataIC50: 780nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50096063(6-(5-Hydroxy-3-{5-[3-(4-methyl-piperazin-1-yl)-pro...)
Affinity DataIC50: 800nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 uM T(S)2.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50615389(CHEMBL5283514)
Affinity DataIC50: 800nMAssay Description:Inhibition of Trypanosoma cruzi TryRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50093211(Spermine derivative | CHEMBL308396)
Affinity DataKi:  850nMAssay Description:The compound was evaluated for inhibition of trypanothione reductase enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50615385(CHEMBL5270809)
Affinity DataIC50: 930nMAssay Description:Inhibition of Trypanosoma cruzi TryRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50185388(N-(3,3-diphenylpropyl)-1-3-[3-({7-[(3-{N-[3-(3,3-d...)
Affinity DataIC50: 950nMAssay Description:Inhibition of Trypanosoma cruzi TRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50335534(1-(1-benzylpiperidin-4-yl)-3-(pyridin-3-yl)thioure...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Trypanosoma cruzi trypanothione reductase assessed as inhibition of thionitrobenzoate formation by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50615383(CHEMBL5273760)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Trypanosoma cruzi TryR expressed in escherichia coli SG5More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50335534(1-(1-benzylpiperidin-4-yl)-3-(pyridin-3-yl)thioure...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Trypanosoma cruzi trypanothione reductase assessed as inhibition of thionitrobenzoate formation by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50019879(CHEMBL279905 | [3-(2-Chloro-phenothiazin-10-yl)-pr...)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50087155(5-(3-Methyl-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)...)
Affinity DataIC50: 1.10E+3nMAssay Description:Concentration required for inhibition of Trypanothione reductase (TcTR) from Trypanosoma cruzi in the presence of 50 uM TS2 as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50096043(5-(3-Methyl-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)...)
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 uM T(S)2.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50091163(Benzhydryl-[3-(2-chloro-phenothiazin-10-yl)-propyl...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50091157((2-Adamantan-1-yl-2-oxo-ethyl)-[3-(2-chloro-phenot...)
Affinity DataKi:  1.23E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50093204(4-(1H-Indol-3-yl)-N-(3-{4-[3-(4-1H-indol-3-yl-buty...)
Affinity DataKi:  1.26E+3nMAssay Description:The compound was evaluated for inhibition of trypanothione reductase enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50091153(Benzyl-[3-(2-chloro-phenothiazin-10-yl)-propyl]-di...)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50096491(N1-(3-aminopropyl)-N1,N4-bis(3-phenylpropyl)-N4-(3...)
Affinity DataKi:  1.38E+3nMAssay Description:Tested for binding affinity against trypanothione reductase from Trypanosoma cruziMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50093207((E)-3-(3,4-Dihydroxy-phenyl)-N-[3-(4-{3-[(E)-3-(3,...)
Affinity DataKi:  1.39E+3nMAssay Description:The compound was evaluated for inhibition of trypanothione reductase enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50096064(5-(3-Methyl-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 uM T(S)2.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
University of Southamton

Curated by ChEMBL
LigandPNGBDBM50091159([2-(4-Chloro-3-methyl-phenyl)-2-oxo-ethyl]-[3-(2-c...)
Affinity DataKi:  1.43E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
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