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TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50071733(Compound GRP | CHEMBL413196)
Affinity DataKi:  0.0400nMAssay Description:In vitro binding affinity at Bombesin BB2 receptor in the presence of [125I]-[Tyr] bombesin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50158698([N40,Pro1,Tyr4]BB | CHEMBL266078)
Affinity DataIC50: 0.0600nMAssay Description:Displacement of [125 I-Tyr4]BB from human gastrin releasing peptide receptor expressed in PC-3 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50275902(D-Phe-Gln-Trp-Ala-Val-b-Ala-His-Phe-Nle-NH2 | CHEM...)
Affinity DataEC50:  0.0600nMAssay Description:Agonist activity at recombinant gastrin releasing peptide receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50158699([(N4-Bzdig)0]BB(7-14) | CHEMBL414307)
Affinity DataIC50: 0.0800nMAssay Description:Displacement of [125 I-Tyr4]BB from human gastrin releasing peptide receptor expressed in PC-3 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM85484(Bombesin)
Affinity DataKi:  0.150nMAssay Description:In vitro binding affinity at Bombesin BB2 receptor in the presence of [125I]-[Tyr] bombesin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50158697([N40,Pro1,Tyr4,Nle 14]BB | CHEMBL268222)
Affinity DataIC50: 0.150nMAssay Description:Displacement of [125 I-Tyr4]BB from human gastrin releasing peptide receptor expressed in PC-3 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM85484(Bombesin)
Affinity DataKi:  0.150nMAssay Description:Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human GRP(gastrin releasing peptide) receptors stably expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM85484(Bombesin)
Affinity DataEC50:  0.258nMAssay Description:Displacement of 125I[Tyr4]-bombesin from GRPR expressed in human PC3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50374870(CHEMBL272335)
Affinity DataEC50:  0.373nMAssay Description:Displacement of 125I[Tyr4]-bombesin from GRPR expressed in human PC3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50158698([N40,Pro1,Tyr4]BB | CHEMBL266078)
Affinity DataIC50: 0.470nMAssay Description:Inhibition of gastrin releasing peptide receptor expressed in human prostate cancer cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50066009(CHEMBL3401466)
Affinity DataKi:  0.5nMAssay Description:Displacement of [125I-Tyr4]bombesin from GRPR (unknown origin) expressed in human PC3 cells after 45 mins by gamma counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2016
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50279041((2S)-N1-((5S,8S,11S,17S,20S,23S,26S,29S,35S,38S)-1...)
Affinity DataIC50: 0.590nMAssay Description:Displacement of [125I-Tyr4]BN form BB2 receptor in human PC3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50158700([(N4-Bzdig)0,Nle14]BB(7-14) | CHEMBL266079)
Affinity DataIC50: 0.600nMAssay Description:Displacement of [125 I-Tyr4]BB from human gastrin releasing peptide receptor expressed in PC-3 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50066009(CHEMBL3401466)
Affinity DataIC50: 0.600nMAssay Description:Displacement of [125I-Tyr4]bombesin from GRPR (unknown origin) expressed in human PC3 cells after 45 mins by gamma counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2016
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50158699([(N4-Bzdig)0]BB(7-14) | CHEMBL414307)
Affinity DataIC50: 0.650nMAssay Description:Inhibition of gastrin releasing peptide receptor expressed in human prostate cancer cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50288252(Bombesin analogue | CHEMBL269432)
Affinity DataKi:  0.700nMAssay Description:Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human GRP(gastrin releasing peptide) receptors stably expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50071744(AcBB(7-14) | CHEMBL314375)
Affinity DataKi:  0.700nMAssay Description:In vitro binding affinity at Bombesin BB2 receptor in the presence of [125I]-[Tyr] bombesin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50158702(Universal ligand | CHEMBL413893)
Affinity DataIC50: 0.720nMAssay Description:Inhibition of gastrin releasing peptide receptor expressed in human prostate cancer cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50158701([Tyr4]Bombesin | CHEMBL407101)
Affinity DataIC50: 0.850nMAssay Description:Displacement of [125 I-Tyr4]BB from human gastrin releasing peptide receptor expressed in PC-3 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50275902(D-Phe-Gln-Trp-Ala-Val-b-Ala-His-Phe-Nle-NH2 | CHEM...)
Affinity DataKi:  0.990nMAssay Description:Binding affinity to gastrin releasing peptide receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50071739((S)-3-(1H-Indol-3-yl)-N-[1-(5-methoxy-pyridin-2-yl...)
Affinity DataKi:  1nMAssay Description:Antagonistic activity against cloned human Bombesin receptor bb2 labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells; 0.66-1.3More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50279043((S)-N1-((5S,8S,11S,17S,20S,23S,26S,29S,35S,38S)-11...)
Affinity DataIC50: 1.24nMAssay Description:Displacement of [125I-Tyr4]BN form BB2 receptor in human PC3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50158700([(N4-Bzdig)0,Nle14]BB(7-14) | CHEMBL266079)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of gastrin releasing peptide receptor expressed in human prostate cancer cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50279042((2S)-N1-((5S,8S,11S,17S,20S,23S)-11-((1H-imidazol-...)
Affinity DataIC50: 1.45nMAssay Description:Displacement of [125I-Tyr4]BN form BB2 receptor in human PC3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50158697([N40,Pro1,Tyr4,Nle 14]BB | CHEMBL268222)
Affinity DataIC50: 1.94nMAssay Description:Inhibition of gastrin releasing peptide receptor expressed in human prostate cancer cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM85484(Bombesin)
Affinity DataIC50: 2nMAssay Description:Displacement of [125I]-Tyr4-BBN from human GRPR overexpressed in human T47D cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50071743((S)-3-(1H-Indol-3-yl)-N-[1-(4-methoxy-phenyl)-cycl...)
Affinity DataKi:  3.70nMAssay Description:In vitro binding affinity at Bombesin BB2 receptor in the presence of [125I]-[Tyr] bombesin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50441006(CHEMBL2429987)
Affinity DataIC50: 5.30nMAssay Description:Displacement of [125I]-Tyr4-bombesin from GRP receptor in human PC3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50071742((S)-N-[1-(4-Ethoxy-phenyl)-cyclohexylmethyl]-3-(1H...)
Affinity DataKi:  5.80nMAssay Description:In vitro binding affinity at Bombesin BB2 receptor in the presence of [125I]-[Tyr] bombesin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50071750((S)-3-(1H-Indol-3-yl)-2-methyl-N-[1-(4-nitro-pheny...)
Affinity DataKi:  6.40nMAssay Description:In vitro binding affinity at Bombesin BB2 receptor in the presence of [125I]-[Tyr] bombesin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50441004(CHEMBL2429980)
Affinity DataIC50: 8.30nMAssay Description:Displacement of [125I]-Tyr4-bombesin from GRP receptor in human PC3 cells after 1 hr by gamma-counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50071741((S)-N-[1-(4-Dimethylamino-phenyl)-cyclohexylmethyl...)
Affinity DataKi:  9nMAssay Description:In vitro binding affinity at Bombesin BB2 receptor in the presence of [125I]-[Tyr] bombesin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50071739((S)-3-(1H-Indol-3-yl)-N-[1-(5-methoxy-pyridin-2-yl...)
Affinity DataIC50: 16nMAssay Description:Antagonistic activity against labelled Bombesin receptor bb2 binding sites in rat cerebral cortex by using [125I]- [Tyr] bombesin in presence of NMB;...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50071735((S)-3-(1H-Indol-3-yl)-2-methyl-2-[3-(4-nitro-pheny...)
Affinity DataKi:  17nMAssay Description:In vitro binding affinity at Bombesin BB2 receptor in the presence of [125I]-[Tyr] bombesin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50425231(CHEMBL2314835)
Affinity DataIC50: 18nMAssay Description:Displacement of [125I]-Tyr4-BBN from human GRPR overexpressed in human T47D cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50441005(CHEMBL2429964)
Affinity DataIC50: 23nMAssay Description:Binding affinity to GRP receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50441003(CHEMBL2429981)
Affinity DataIC50: 23nMAssay Description:Displacement of [125I]-Tyr4-bombesin from GRP receptor in human PC3 cells after 1 hr by gamma-counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50071738((S)-N-[1-(4-Hydroxy-phenyl)-cyclohexylmethyl]-3-(1...)
Affinity DataKi:  32nMAssay Description:In vitro binding affinity at Bombesin BB2 receptor in the presence of [125I]-[Tyr] bombesin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50071736((S)-N-[1-(3,4-Dimethoxy-phenyl)-cyclohexylmethyl]-...)
Affinity DataKi:  33nMAssay Description:In vitro binding affinity at Bombesin BB2 receptor in the presence of [125I]-[Tyr] bombesin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50127532(Val-Pro-Leu-Pro-Ala-Gly-Gly-Gly-Thr-Val-Leu-Thr-Ly...)
Affinity DataEC50:  34nMAssay Description:Effective concentration required against gastrin releasing peptide receptor (GRP-R) in CHO cells by using FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50071749((S)-3-(1H-Indol-3-yl)-N-[1-(4-isopropyl-phenyl)-cy...)
Affinity DataKi:  35nMAssay Description:In vitro binding affinity at Bombesin BB2 receptor in the presence of [125I]-[Tyr] bombesin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50071746((S)-2-[3-(4-Cyano-phenyl)-ureido]-3-(1H-indol-3-yl...)
Affinity DataKi:  37nMAssay Description:In vitro binding affinity at Bombesin BB2 receptor in the presence of [125I]-[Tyr] bombesin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50071745(NMB | CHEMBL403317 | Compound NMB | Gly-Asn-Leu-Tr...)
Affinity DataEC50:  41nMAssay Description:Effective concentration required against gastrin releasing peptide receptor (GRP-R) in CHO cells by using FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50071745(NMB | CHEMBL403317 | Compound NMB | Gly-Asn-Leu-Tr...)
Affinity DataKi:  56nMAssay Description:In vitro binding affinity at Bombesin BB2 receptor in the presence of [125I]-[Tyr] bombesin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50127519([D-Tyr6-, Beta-Ala11, Phe13, Nle14] Bn (6-14)(Bomb...)
Affinity DataEC50:  84nMAssay Description:Effective concentration required against gastrin releasing peptide receptor (GRP-R) in CHO cells by using FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50071737((S)-3-(1H-Indol-3-yl)-2-methyl-2-[3-(3-nitro-pheny...)
Affinity DataKi:  85nMAssay Description:In vitro binding affinity at Bombesin BB2 receptor in the presence of [125I]-[Tyr] bombesin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50071734((S)-2-[3-(3,4-Dichloro-phenyl)-ureido]-3-(1H-indol...)
Affinity DataKi:  85nMAssay Description:In vitro binding affinity at Bombesin BB2 receptor in the presence of [125I]-[Tyr] bombesin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50071748((S)-3-(1H-Indol-3-yl)-2-methyl-2-[3-(4-nitro-pheny...)
Affinity DataKi:  89nMAssay Description:In vitro binding affinity at Bombesin BB2 receptor in the presence of [125I]-[Tyr] bombesin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50071753((S)-3-(1H-Indol-3-yl)-2-methyl-N-(1-pyridin-2-yl-c...)
Affinity DataKi:  124nMAssay Description:In vitro binding affinity at Bombesin BB2 receptor in the presence of [125I]-[Tyr] bombesin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetGastrin-releasing peptide receptor(Human)
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50071740((S)-2-[3-(4-Chloro-phenyl)-ureido]-3-(1H-indol-3-y...)
Affinity DataKi:  149nMAssay Description:In vitro binding affinity at Bombesin BB2 receptor in the presence of [125I]-[Tyr] bombesin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
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