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TargetB-cell lymphoma 6 protein [5-128](Human)
Ontario Institute for Cancer Research

LigandPNGBDBM536505((S)-7-(1-(2-((3-chloro- 6-(2,4-dimethylpipera- zin...)
Affinity DataKd:  0.5nMAssay Description:We used a more sensitive Surface Plasmon Resonance (SPR) assay to quantitate the direct binding affinity of ligands to purified BCL6-BTB dimer.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
PubMed
TargetB-cell lymphoma 6 protein [5-128](Human)
Ontario Institute for Cancer Research

LigandPNGBDBM536505((S)-7-(1-(2-((3-chloro- 6-(2,4-dimethylpipera- zin...)
Affinity DataKd:  0.5nMAssay Description:We used a more sensitive Surface Plasmon Resonance (SPR) assay to quantitate the direct binding affinity of ligands to purified BCL6-BTB dimer. Data...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
PubMed
TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50260529(CHEMBL4077626)
Affinity DataKd:  0.570nMAssay Description:Binding affinity to human BCL6 BTP domain assessed as dissociation constant by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50260529(CHEMBL4077626)
Affinity DataKd:  0.570nMAssay Description:Binding affinity to biotinylated BCL6 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2020
Entry Details Article
PubMed
TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50260529(CHEMBL4077626)
Affinity DataKd:  0.570nMAssay Description:Inhibition of BCOR binding to recombinant biotinylated SUMO-tagged BCL6 BTB domain (5 to 129 amino acid residues) (unknown origin) expressed in Esche...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details Article
PubMed
TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50602180(CHEMBL5195604)
Affinity DataKd:  0.600nMAssay Description:Binding affinity to BCL6 BTB domain (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50606290(CHEMBL5205388 | US20230287003, Example 13d)
Affinity DataEC50:  0.700nMAssay Description:Degradation of BCL6 in human OCI-Ly1 cells incubated for 2 hrs by MSD assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50621658(CHEMBL5396792)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of N-terminal Trx/6His/HRV3C-tagged human BCL6 BTB domain (5 to 129 residues) expressed in Escherichia coli BL21-AI using RSEIISTAPSSWVVPG...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50260529(CHEMBL4077626)
Affinity DataIC50: 1nMAssay Description:Inhibition of C-terminal biotin-labelled BCoR (Arg498 to 514Pro residues) binding to recombinant FLAG-tagged BCL6 BTB (5 to 129 residues) (unknown or...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/14/2020
Entry Details Article
PubMed
TargetB-cell lymphoma 6 protein [5-128](Human)
Ontario Institute for Cancer Research

LigandPNGBDBM582302(US11518764, Compound I-311 | acsmedchemlett.2c0050...)
Affinity DataKd:  1nMAssay Description:We used a more sensitive Surface Plasmon Resonance (SPR) assay to quantitate the direct binding affinity of ligands to purified BCL6-BTB dimer.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
PubMed
TargetB-cell lymphoma 6 protein [5-128](Human)
Ontario Institute for Cancer Research

LigandPNGBDBM582302(US11518764, Compound I-311 | acsmedchemlett.2c0050...)
Affinity DataKd:  1nMAssay Description:We used a more sensitive Surface Plasmon Resonance (SPR) assay to quantitate the direct binding affinity of ligands to purified BCL6-BTB dimer. Data...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
PubMed
TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50260529(CHEMBL4077626)
Affinity DataIC50: 1nMAssay Description:Inhibition of human BCL6 BTP domain by ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details Article
PubMed
TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50602180(CHEMBL5195604)
Affinity DataKd:  1nMAssay Description:Inhibition of FLAG tagged human BCL6 (5 to 129 residues) by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50606290(CHEMBL5205388 | US20230287003, Example 13d)
Affinity DataEC50:  1nMAssay Description:Degradation of BCL6 in human KARPAS-422 cells by MSD assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetB-cell lymphoma 6 protein [5-128](Human)
Ontario Institute for Cancer Research

LigandPNGBDBM582458(US11518764, Compound I-471 | acsmedchemlett.2c0050...)
Affinity DataKd:  1nMAssay Description:We used a more sensitive Surface Plasmon Resonance (SPR) assay to quantitate the direct binding affinity of ligands to purified BCL6-BTB dimer.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
PubMed
TargetB-cell lymphoma 6 protein [5-128](Human)
Ontario Institute for Cancer Research

LigandPNGBDBM582458(US11518764, Compound I-471 | acsmedchemlett.2c0050...)
Affinity DataKd:  1nMAssay Description:We used a more sensitive Surface Plasmon Resonance (SPR) assay to quantitate the direct binding affinity of ligands to purified BCL6-BTB dimer. Data...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
PubMed
TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM582302(US11518764, Compound I-311 | acsmedchemlett.2c0050...)
Affinity DataKd:  1.04nMAssay Description:SPR studies were performed using a Biacore™ T200 instrument (GE Health Sciences Inc.). The BCL6 BTB protein used in the FP assay was biotinylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2023
Entry Details
US Patent

TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM582458(US11518764, Compound I-471 | acsmedchemlett.2c0050...)
Affinity DataKd:  1.05nMAssay Description:SPR studies were performed using a Biacore™ T200 instrument (GE Health Sciences Inc.). The BCL6 BTB protein used in the FP assay was biotinylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2023
Entry Details
US Patent

TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM618556(US20230287003, Example 11c)
Affinity DataIC50: 1.17nMAssay Description:Each 15 μL HTRF reaction in a 384-well black Proxiplate (Perkin Elmer) contained 1 nM Trx-6×His-BCL6 (in house-produced, human BCL6 BTB domain c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50621660(CHEMBL5394661)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of N-terminal Trx/6His/HRV3C-tagged human BCL6 BTB domain (5 to 129 residues) expressed in Escherichia coli BL21-AI using RSEIISTAPSSWVVPG...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM582362(US11518764, Compound I-375)
Affinity DataKd:  1.31nMAssay Description:SPR studies were performed using a Biacore™ T200 instrument (GE Health Sciences Inc.). The BCL6 BTB protein used in the FP assay was biotinylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2023
Entry Details
US Patent

TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM618578(US20230287003, Example 12v)
Affinity DataIC50: 1.38nMAssay Description:Each 15 μL HTRF reaction in a 384-well black Proxiplate (Perkin Elmer) contained 1 nM Trx-6×His-BCL6 (in house-produced, human BCL6 BTB domain c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM618578(US20230287003, Example 12v)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of N-terminal Trx/6His/HRV3C-tagged human BCL6 BTB domain (5 to 129 residues) expressed in Escherichia coli BL21-AI using RSEIISTAPSSWVVPG...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50606282(CHEMBL5204505 | US20230287003, Example 12p)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of N-terminal thioredoxin-His6 tagged human BCL6 BTB domain (5 to 129 residues) expressed in Escherichia coli BL21-AI incubated for 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM618557(US20230287003, Example 12a)
Affinity DataIC50: 1.51nMAssay Description:Each 15 μL HTRF reaction in a 384-well black Proxiplate (Perkin Elmer) contained 1 nM Trx-6×His-BCL6 (in house-produced, human BCL6 BTB domain c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM618554(US20230287003, Example 11a)
Affinity DataIC50: 1.55nMAssay Description:Each 15 μL HTRF reaction in a 384-well black Proxiplate (Perkin Elmer) contained 1 nM Trx-6×His-BCL6 (in house-produced, human BCL6 BTB domain c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM582149(US11518764, Compound I-158)
Affinity DataKd:  1.76nMAssay Description:SPR studies were performed using a Biacore™ T200 instrument (GE Health Sciences Inc.). The BCL6 BTB protein used in the FP assay was biotinylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2023
Entry Details
US Patent

TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM618585(US20230287003, Example 13c)
Affinity DataIC50: 1.78nMAssay Description:Each 15 μL HTRF reaction in a 384-well black Proxiplate (Perkin Elmer) contained 1 nM Trx-6×His-BCL6 (in house-produced, human BCL6 BTB domain c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM618579(US20230287003, Example 12w)
Affinity DataIC50: 1.86nMAssay Description:Each 15 μL HTRF reaction in a 384-well black Proxiplate (Perkin Elmer) contained 1 nM Trx-6×His-BCL6 (in house-produced, human BCL6 BTB domain c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM582344(US11518764, Compound I-357)
Affinity DataKd:  1.86nMAssay Description:SPR studies were performed using a Biacore™ T200 instrument (GE Health Sciences Inc.). The BCL6 BTB protein used in the FP assay was biotinylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2023
Entry Details
US Patent

TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM582443(US11518764, Compound I-456)
Affinity DataKd:  1.87nMAssay Description:SPR studies were performed using a Biacore™ T200 instrument (GE Health Sciences Inc.). The BCL6 BTB protein used in the FP assay was biotinylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2023
Entry Details
US Patent

TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50621659(CHEMBL5427058)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of N-terminal Trx/6His/HRV3C-tagged human BCL6 BTB domain (5 to 129 residues) expressed in Escherichia coli BL21-AI using RSEIISTAPSSWVVPG...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50606290(CHEMBL5205388 | US20230287003, Example 13d)
Affinity DataIC50: 2nMAssay Description:Each 15 μL HTRF reaction in a 384-well black Proxiplate (Perkin Elmer) contained 1 nM Trx-6×His-BCL6 (in house-produced, human BCL6 BTB domain c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM582103(US11518764, Compound I-74)
Affinity DataKd:  2nMAssay Description:SPR studies were performed using a Biacore™ T200 instrument (GE Health Sciences Inc.). The BCL6 BTB protein used in the FP assay was biotinylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2023
Entry Details
US Patent

TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM582299(US11518764, Compound I-308)
Affinity DataKd:  2.05nMAssay Description:SPR studies were performed using a Biacore™ T200 instrument (GE Health Sciences Inc.). The BCL6 BTB protein used in the FP assay was biotinylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2023
Entry Details
US Patent

TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM618583(US20230287003, Example 13a)
Affinity DataIC50: 2.09nMAssay Description:Each 15 μL HTRF reaction in a 384-well black Proxiplate (Perkin Elmer) contained 1 nM Trx-6×His-BCL6 (in house-produced, human BCL6 BTB domain c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM618588(US20230287003, Example 13f)
Affinity DataIC50: 2.19nMAssay Description:Each 15 μL HTRF reaction in a 384-well black Proxiplate (Perkin Elmer) contained 1 nM Trx-6×His-BCL6 (in house-produced, human BCL6 BTB domain c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50606290(CHEMBL5205388 | US20230287003, Example 13d)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of N-terminal thioredoxin-His6 tagged human BCL6 BTB domain (5 to 129 residues) expressed in Escherichia coli BL21-AI incubated for 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50606280(CHEMBL5205212)
Affinity DataEC50:  2.20nMAssay Description:Degradation of BCL6 in human OCI-Ly1 cells incubated for 2 hrs by MSD assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50606281(CHEMBL5203177 | US20230287003, Example 12q)
Affinity DataIC50: 2.24nMAssay Description:Each 15 μL HTRF reaction in a 384-well black Proxiplate (Perkin Elmer) contained 1 nM Trx-6×His-BCL6 (in house-produced, human BCL6 BTB domain c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM582221(US11518764, Compound I-230)
Affinity DataKd:  2.32nMAssay Description:SPR studies were performed using a Biacore™ T200 instrument (GE Health Sciences Inc.). The BCL6 BTB protein used in the FP assay was biotinylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2023
Entry Details
US Patent

TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM582415(US11518764, Compound I-428)
Affinity DataKd:  2.35nMAssay Description:SPR studies were performed using a Biacore™ T200 instrument (GE Health Sciences Inc.). The BCL6 BTB protein used in the FP assay was biotinylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2023
Entry Details
US Patent

TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM582419(US11518764, Compound I-432)
Affinity DataKd:  2.39nMAssay Description:SPR studies were performed using a Biacore™ T200 instrument (GE Health Sciences Inc.). The BCL6 BTB protein used in the FP assay was biotinylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2023
Entry Details
US Patent

TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50606295(CHEMBL5171519)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of N-terminal thioredoxin-His6 tagged human BCL6 BTB domain (5 to 129 residues) expressed in Escherichia coli BL21-AI incubated for 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM582425(US11518764, Compound I-438)
Affinity DataKd:  2.5nMAssay Description:SPR studies were performed using a Biacore™ T200 instrument (GE Health Sciences Inc.). The BCL6 BTB protein used in the FP assay was biotinylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2023
Entry Details
US Patent

TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM618592(US20230287003, Example 13j)
Affinity DataIC50: 2.51nMAssay Description:Each 15 μL HTRF reaction in a 384-well black Proxiplate (Perkin Elmer) contained 1 nM Trx-6×His-BCL6 (in house-produced, human BCL6 BTB domain c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50606291(CHEMBL5196650 | US20230287003, Example 13e)
Affinity DataIC50: 2.51nMAssay Description:Each 15 μL HTRF reaction in a 384-well black Proxiplate (Perkin Elmer) contained 1 nM Trx-6×His-BCL6 (in house-produced, human BCL6 BTB domain c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM618584(US20230287003, Example 13b)
Affinity DataIC50: 2.57nMAssay Description:Each 15 μL HTRF reaction in a 384-well black Proxiplate (Perkin Elmer) contained 1 nM Trx-6×His-BCL6 (in house-produced, human BCL6 BTB domain c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50597108(CHEMBL5184251 | US20230287003, Example 1v)
Affinity DataIC50: 2.63nMAssay Description:Each 15 μL HTRF reaction in a 384-well black Proxiplate (Perkin Elmer) contained 1 nM Trx-6×His-BCL6 (in house-produced, human BCL6 BTB domain c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetB-cell lymphoma 6 protein(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM618577(US20230287003, Example 12u)
Affinity DataIC50: 2.63nMAssay Description:Each 15 μL HTRF reaction in a 384-well black Proxiplate (Perkin Elmer) contained 1 nM Trx-6×His-BCL6 (in house-produced, human BCL6 BTB domain c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
US Patent

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