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TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50083912(2-(4-Ethynyl-phenyl)-2,5-dihydro-pyrazolo[4,3-c]qu...)
Affinity DataKi:  0.0300nMAssay Description:Binding affinity to human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-2-beta-3-gamma-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50599948(PHENAZEPAM)
Affinity DataKi:  0.0600nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant alpha2beta2gamma2 GABAA receptor expressed in HEK cell membrane by competitive radioligand b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50083898(8-Ethynyl-2-phenyl-2,5-dihydro-pyrazolo[4,3-c]quin...)
Affinity DataKi:  0.0600nMAssay Description:Binding affinity to human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-2-beta-3-gamma-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandPNGBDBM751588(US20250197368, Example 100)
Affinity DataKi:  0.0700nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50083893(8-Bromo-2-phenyl-2,5-dihydro-pyrazolo[4,3-c]quinol...)
Affinity DataKi:  0.0800nMAssay Description:Binding affinity to human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-2-beta-3-gamma-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50017009(CHEMBL19732 | 2-Phenyl-2,5-dihydro-pyrazolo[4,3-c]...)
Affinity DataKi:  0.0800nMAssay Description:Binding affinity to human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-2-beta-3-gamma-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM85042(CHEMBL44613 | PW-007A)
Affinity DataKi:  0.100nMAssay Description:Binding affinity to human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-2-beta-3-gamma-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandPNGBDBM751601(US20250197368, Example 113)
Affinity DataKi:  0.120nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50599949(CHEMBL3274851)
Affinity DataKi:  0.150nMAssay Description:Displacement of [3H]flunitrazepam from human recombinant alpha2beta2gamma2 GABAA receptor expressed in HEK cell membrane by competitive radioligand b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50083903(7-Chloro-5-furan-2-yl-1-methyl-1,3-dihydro-benzo[e...)
Affinity DataKi: >0.170nMAssay Description:Binding affinity to human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-2-beta-3-gamma-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandPNGBDBM751597(US20250197368, Example 109)
Affinity DataKi:  0.170nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandPNGBDBM751622(US20250197368, Example 134)
Affinity DataKi:  0.170nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50034837(8-Chloro-2-phenyl-2,5-dihydro-pyrazolo[4,3-c]quino...)
Affinity DataKi:  0.170nMAssay Description:Binding affinity to human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-2-beta-3-gamma-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandPNGBDBM751589(US20250197368, Example 101)
Affinity DataKi:  0.190nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandPNGBDBM751595(US20250197368, Example 107)
Affinity DataKi:  0.200nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50083905(2-(4-Bromo-phenyl)-2,5-dihydro-pyrazolo[4,3-c]quin...)
Affinity DataKi:  0.210nMAssay Description:Binding affinity to human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-2-beta-3-gamma-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandPNGBDBM751538(US20250197368, Example 50)
Affinity DataKi:  0.210nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandPNGBDBM751593(US20250197368, Example 105)
Affinity DataKi:  0.210nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandPNGBDBM751599(US20250197368, Example 111)
Affinity DataKi:  0.230nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandPNGBDBM751535(US20250197368, Example 47)
Affinity DataKi:  0.230nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandPNGBDBM751587(US20250197368, Example 99)
Affinity DataKi:  0.240nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50176776(7-cyclobutyl-6-(2-methyl-2H-1,2,4-trizol-3-ylmetho...)
Affinity DataKi:  0.25nMAssay Description:Displacement of [3H]Ro 15-1788 from human recombinant GABAA alpha-2-beta-3-gamma-2 receptor expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandPNGBDBM751497(US20250197368, Example 9)
Affinity DataKi:  0.25nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandPNGBDBM50142567(9-(4-Methyl-thiazol-2-yl)-11-phenyl-6,7-dihydro-5H...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]Ro-151788 from human GABA-A receptor alpha2 subunit expressed in L(tk) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50176771(7-tert-butyl-6-((2-ethyl-2H-1,2,4-triazol-3-yl)met...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]-Ro15-1788 from human recombinant GABAA alpha2 in combination with beta3gamma2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandPNGBDBM751573(US20250197368, Example 85)
Affinity DataKi:  0.300nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandPNGBDBM751609(US20250197368, Example 121)
Affinity DataKi:  0.300nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandPNGBDBM50418481(CHEMBL1783282)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to GABA-A alpha2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandPNGBDBM751619(US20250197368, Example 131)
Affinity DataKi:  0.300nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50418481(CHEMBL1783282)
Affinity DataKi:  0.309nMAssay Description:Displacement of [3H]flunitrazepam from benzodiazepine binding site GABAA alpha2beta3gamma2 receptor expressed in Sf9 cells after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandPNGBDBM50418481(CHEMBL1783282)
Affinity DataKi:  0.309nMAssay Description:Binding affinity to GABA-A alpha2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandPNGBDBM751607(US20250197368, Example 119)
Affinity DataKi:  0.310nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50176771(7-tert-butyl-6-((2-ethyl-2H-1,2,4-triazol-3-yl)met...)
Affinity DataKi:  0.310nMAssay Description:Displacement of [3H]Ro 15-1788 from human recombinant GABAA alpha-2-beta-3-gamma-2 receptor expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandPNGBDBM751613(US20250197368, Example 125)
Affinity DataKi:  0.370nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50418483(CHEMBL1783284)
Affinity DataKi:  0.380nMAssay Description:Displacement of [3H]flunitrazepam from benzodiazepine binding site GABAA alpha2beta3gamma2 receptor expressed in Sf9 cells after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandPNGBDBM751496(US20250197368, Example 8)
Affinity DataKi:  0.380nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandPNGBDBM751596(US20250197368, Example 108)
Affinity DataKi:  0.390nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandPNGBDBM751529(US20250197368, Example 41)
Affinity DataKi:  0.400nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50179995(3'-(7-methyl-imidazo[1,2-a]pyrimidin-3-yl)-bipheny...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H] Ro15-1788 from recombinant human GABAA alpha2 receptor plus beta-3-gamma-2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50418482(CHEMBL1783283)
Affinity DataKi:  0.407nMAssay Description:Displacement of [3H]flunitrazepam from benzodiazepine binding site GABAA alpha2beta3gamma2 receptor expressed in Sf9 cells after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandPNGBDBM751594(US20250197368, Example 106)
Affinity DataKi:  0.410nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandPNGBDBM751537(US20250197368, Example 49)
Affinity DataKi:  0.430nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandPNGBDBM751583(US20250197368, Example 95)
Affinity DataKi:  0.440nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandPNGBDBM751579(US20250197368, Example 91)
Affinity DataKi:  0.460nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandPNGBDBM751580(US20250197368, Example 92)
Affinity DataKi:  0.480nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandPNGBDBM751606(US20250197368, Example 118)
Affinity DataKi:  0.5nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50180004(2-fluoro-5-(7-trifluoromethylimidazo[1,2-a]pyrimid...)
Affinity DataKi:  0.520nMAssay Description:Displacement of [3H]-Ro15-1788 from human recombinant GABAA alpha2 in combination with beta3gamma2 expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandPNGBDBM751530(US20250197368, Example 42)
Affinity DataKi:  0.560nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50418488(CHEMBL1783285)
Affinity DataKi:  0.562nMAssay Description:Displacement of [3H]flunitrazepam from benzodiazepine binding site GABAA alpha2beta3gamma2 receptor expressed in Sf9 cells after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
University College Cardiff Consultants

US Patent
LigandPNGBDBM751600(US20250197368, Example 112)
Affinity DataKi:  0.570nMAssay Description:The affinity (Ki) of compounds for the benzodiazepine site of human recombinant GABAARs was measured by their ability to inhibit the binding of the s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

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