Compile Data Set for Download or QSAR
Report error Found 43 of affinity data for UniProtKB/TrEMBL: P56818
TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 400979BDBM400979(US9999624, Compound 4)
Affinity DataIC50: 0.275nMAssay Description:Inhibition of BACE1 in mouse primary cortical neuron assessed as reduction in Amyloid-beta level incubated for 24 hrs by sandwich ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 150693BDBM150693(US8987254, 8 | US9999624, 9)
Affinity DataIC50: 0.309nMAssay Description:Inhibition of BACE1 in mouse primary cortical neuron assessed as reduction in Amyloid-beta level incubated for 24 hrs by sandwich ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 150688BDBM150688(US8987254, 3 | US9999624, 3)
Affinity DataIC50: 0.481nMAssay Description:Inhibition of BACE1 in mouse primary cortical neuron assessed as reduction in Amyloid-beta level incubated for 24 hrs by sandwich ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50393088BDBM50393088(CHEMBL2152903)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of BACE1-mediated amyloid beta 40 release in C57/BL6 mouse primary cortical neurons after overnight incubation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 165909BDBM165909(US9067924, 3)
Affinity DataIC50: 3nMAssay Description:An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
US Patent

TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50398267BDBM50398267(CHEMBL2177304)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of BACE1-mediated amyloid beta 40 release in C57/BL6 mouse primary cortical neurons after overnight incubation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 165913BDBM165913(US9067924, 7)
Affinity DataIC50: 4nMAssay Description:An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
US Patent

TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50131773BDBM50131773(CHEMBL3634123)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of BACE1 in mouse Neuro-2a cells expressing wild type human APP695 assessed as reduction in amyloid beta-42 production after 18 hrs by san...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50131774BDBM50131774(CHEMBL2403769)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of BACE1 in mouse Neuro-2a cells expressing wild type human APP695 assessed as reduction in amyloid beta-42 production after 18 hrs by san...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 165907BDBM165907(US9067924, 1)
Affinity DataIC50: 6.30nMAssay Description:An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
US Patent

TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50131775BDBM50131775(CHEMBL3634122)
Affinity DataIC50: 7.40nMAssay Description:Inhibition of BACE1 in mouse Neuro-2a cells expressing wild type human APP695 assessed as reduction in amyloid beta-42 production after 18 hrs by san...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 210070BDBM210070(US9270353, 17)
Affinity DataIC50: 9.70nMAssay Description:Inhibition of mouse BACE1 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50012647BDBM50012647(CHEMBL2396989)
Affinity DataIC50: 11nMAssay Description:Inhibition of BACE1 in mouse primary cortical neuron assessed as reduction in Amyloid-beta level incubated for 24 hrs by sandwich ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 165908BDBM165908(US9067924, 2)
Affinity DataIC50: 16nMAssay Description:An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
US Patent

TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 165910BDBM165910(US9067924, 4)
Affinity DataIC50: 20nMAssay Description:An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
US Patent

TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50398261BDBM50398261(CHEMBL2177919)
Affinity DataIC50: 30nMAssay Description:Inhibition of BACE1-mediated amyloid beta 40 release in C57/BL6 mouse primary cortical neurons after overnight incubation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 165914BDBM165914(US9067924, 8)
Affinity DataIC50: 30nMAssay Description:An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
US Patent

TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50398262BDBM50398262(CHEMBL2177917)
Affinity DataIC50: 40nMAssay Description:Inhibition of BACE1-mediated amyloid beta 40 release in C57/BL6 mouse primary cortical neurons after overnight incubation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50398264BDBM50398264(CHEMBL2177913)
Affinity DataIC50: 51nMAssay Description:Inhibition of BACE1-mediated amyloid beta 40 release in C57/BL6 mouse primary cortical neurons after overnight incubation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50398263BDBM50398263(CHEMBL2177914)
Affinity DataIC50: 53nMAssay Description:Inhibition of BACE1-mediated amyloid beta 40 release in C57/BL6 mouse primary cortical neurons after overnight incubation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 165918BDBM165918(US9067924, 12)
Affinity DataIC50: 53nMAssay Description:An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
US Patent

TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 165916BDBM165916(US9067924, 10)
Affinity DataIC50: 62nMAssay Description:An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
US Patent

TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50398265BDBM50398265(CHEMBL2177904)
Affinity DataIC50: 68nMAssay Description:Inhibition of BACE1-mediated amyloid beta 40 release in C57/BL6 mouse primary cortical neurons after overnight incubation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 165920BDBM165920(US9067924, 14)
Affinity DataIC50: 78nMAssay Description:An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
US Patent

TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50012632BDBM50012632(CHEMBL2333941)
Affinity DataIC50: 126nMAssay Description:Inhibition of BACE1 in mouse primary cortical neuron assessed as reduction in Amyloid-beta level incubated for 24 hrs by sandwich ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 165912BDBM165912(US9067924, 6)
Affinity DataIC50: 140nMAssay Description:An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
US Patent

TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 165911BDBM165911(US9067924, 5)
Affinity DataIC50: 170nMAssay Description:An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
US Patent

TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50398277BDBM50398277(CHEMBL2177909)
Affinity DataIC50: 204nMAssay Description:Inhibition of BACE1-mediated amyloid beta 40 release in C57/BL6 mouse primary cortical neurons after overnight incubation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 165919BDBM165919(US9067924, 13)
Affinity DataIC50: 260nMAssay Description:An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
US Patent

TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50581132BDBM50581132(CHEMBL5088790)
Affinity DataIC50: 275nMAssay Description:Inhibition of BACE1 in mouse primary cortical neuron assessed as reduction in Amyloid-beta level incubated for 24 hrs by sandwich ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 165915BDBM165915(US9067924, 9)
Affinity DataIC50: 300nMAssay Description:An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
US Patent

TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50581133BDBM50581133(CHEMBL5093835)
Affinity DataIC50: 324nMAssay Description:Inhibition of BACE1 in mouse primary cortical neuron assessed as reduction in Amyloid-beta level incubated for 24 hrs by sandwich ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50398279BDBM50398279(CHEMBL2177906)
Affinity DataIC50: 436nMAssay Description:Inhibition of BACE1-mediated amyloid beta 40 release in C57/BL6 mouse primary cortical neurons after overnight incubation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50182443BDBM50182443(CHEMBL3819646)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of mouse BACE-1 preincubated for 10 mins followed by fluorescent peptide substrate addition measured for 30 mins by fluorescence plate rea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2017
Entry Details Article
PubMed
TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50280646BDBM50280646(2-[1-(1-Benzyl-piperidin-4-yl)-meth-(E)-ylidene]-5...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of mouse BACE-1 preincubated for 10 mins followed by fluorescent peptide substrate addition measured for 30 mins by fluorescence plate rea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2017
Entry Details Article
PubMed
TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50182442BDBM50182442(CHEMBL3818616)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of mouse BACE-1 preincubated for 10 mins followed by fluorescent peptide substrate addition measured for 30 mins by fluorescence plate rea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2017
Entry Details Article
PubMed
TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50182437BDBM50182437(CHEMBL3819531)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of mouse BACE-1 preincubated for 10 mins followed by fluorescent peptide substrate addition measured for 30 mins by fluorescence plate rea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2017
Entry Details Article
PubMed
TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50182435BDBM50182435(CHEMBL3818084)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of mouse BACE-1 preincubated for 10 mins followed by fluorescent peptide substrate addition measured for 30 mins by fluorescence plate rea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2017
Entry Details Article
PubMed
TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50182436BDBM50182436(CHEMBL3818801)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of mouse BACE-1 preincubated for 10 mins followed by fluorescent peptide substrate addition measured for 30 mins by fluorescence plate rea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2017
Entry Details Article
PubMed
TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50581135BDBM50581135(CHEMBL3701715)
Affinity DataIC50: 1.21E+3nMAssay Description:Inhibition of BACE1 in mouse primary cortical neuron assessed as reduction in Amyloid-beta level incubated for 24 hrs by sandwich ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50581134BDBM50581134(CHEMBL5091705)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of BACE1 in mouse primary cortical neuron assessed as reduction in Amyloid-beta level incubated for 24 hrs by sandwich ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 165917BDBM165917(US9067924, 11)
Affinity DataIC50: 2.29E+3nMAssay Description:An ELISA assay (using a pair of mouse anti-human-TMEM27 antibodies, raised against the extracellular domain of TMEM27) is used for detection of TMEM2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
US Patent

TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50581136BDBM50581136(CHEMBL3701713)
Affinity DataIC50: 2.46E+3nMAssay Description:Inhibition of BACE1 in mouse primary cortical neuron assessed as reduction in Amyloid-beta level incubated for 24 hrs by sandwich ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)