Compile Data Set for Download or QSAR
Report error Found 53 of affinity data for UniProtKB/TrEMBL: Q16478
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50060627((S)-2-amino-3-(5-iodo-2,4-dioxo-3,4-dihydropyrimid...)
Affinity DataKi:  0.240nMAssay Description:Displacement of [3H]kainate from human Ionotropic glutamate receptor ionotropic kainate 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50060630((S)-2-Amino-3-(6-bromo-3,5-dioxo-4,5-dihydro-3H-[1...)
Affinity DataKi:  2.90nMAssay Description:Displacement of [3H]kainate from human Ionotropic glutamate receptor ionotropic kainate 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50002369(Digensaeure | (3S,4R)-3-(carboxymethyl)-4-(prop-1-...)
Affinity DataKi:  8nMAssay Description:Ability to bind to Ionotropic glutamate receptor kainate (kainate 2) was evaluated.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50060636(2-AMINO-3-(5-BROMO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMI...)
Affinity DataKi:  9.10nMAssay Description:Displacement of [3H]kainate from human Ionotropic glutamate receptor ionotropic kainate 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50060629((S)-2-Amino-3-(6-iodo-3,5-dioxo-4,5-dihydro-3H-[1,...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]kainate from human Ionotropic glutamate receptor ionotropic kainate 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50060628((S)-2-Amino-3-(6-chloro-3,5-dioxo-4,5-dihydro-3H-[...)
Affinity DataKi:  31nMAssay Description:Displacement of [3H]kainate from human Ionotropic glutamate receptor ionotropic kainate 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM86754(LY-466195 | LY 466195)
Affinity DataKi:  50nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50060632((S)-2-amino-3-(5-chloro-2,4-dioxo-3,4-dihydropyrim...)
Affinity DataKi:  57nMAssay Description:Displacement of [3H]kainate from human Ionotropic glutamate receptor ionotropic kainate 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50002369(Digensaeure | (3S,4R)-3-(carboxymethyl)-4-(prop-1-...)
Affinity DataKi:  80nMAssay Description:Binding affinity of compound was determined against KA2 using cell membranes prepared from HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50126761(2-Amino-3-(5-tert-butyl-3-hydroxy-isothiazol-4-yl)...)
Affinity DataEC50:  100nMAssay Description:Electrophysiological data on Xenopus oocytes, expressing homomeric kainate receptor (GluR5)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50126764((S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta...)
Affinity DataEC50:  130nMAssay Description:Electrophysiological data on Xenopus oocytes, expressing homomeric Ionotropic glutamate receptor ionotropic kainate 1 (GluR5)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50002369(Digensaeure | (3S,4R)-3-(carboxymethyl)-4-(prop-1-...)
Affinity DataKi:  177nMAssay Description:Displacement of [3H]kainate from human Ionotropic glutamate receptor ionotropic kainate 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50060631((S)-2-Amino-3-(5-nitro-2,4-dioxo-3,4-dihydro-2H-py...)
Affinity DataKi:  393nMAssay Description:Displacement of [3H]kainate from human Ionotropic glutamate receptor ionotropic kainate 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50126763((S)-2-amino-3-(3-hydroxy-5-tert-butyl-4-isoxazolyl...)
Affinity DataEC50:  480nMAssay Description:Electrophysiological data on Xenopus oocytes, expressing homomeric Ionotropic glutamate receptor ionotropic kainate 1 (GluR5)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataKi:  701nMAssay Description:Displacement of [3H]kainate from human Ionotropic glutamate receptor ionotropic kainate 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM17657(L-Glutamic acid | L-Glu | (2S)-2-aminopentanedioic...)
Affinity DataKi:  750nMAssay Description:Binding affinity of compound was determined against KA2 using cell membranes prepared from HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM26431((2R)-2-aminopentanedioic acid | D-Glu | D-Glutamat...)
Affinity DataKi:  750nMAssay Description:Ability to bind to Ionotropic glutamate receptor kainate (kainate 2) was evaluated.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50060633((S)-2-Amino-3-(6-methyl-3,5-dioxo-4,5-dihydro-3H-[...)
Affinity DataKi:  1.15E+3nMAssay Description:Displacement of [3H]kainate from human Ionotropic glutamate receptor ionotropic kainate 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50116049((6-Nitro-2,3-dioxo-7-pyrrol-1-yl-3,4-dihydro-2H-qu...)
Affinity DataKi:  1.30E+3nMAssay Description:Binding affinity towards cloned human Kai-2 subunit stably expressed in cultured HEK293 cells using [3]H-kainate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM86749(LY 457691)
Affinity DataKi:  1.55E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM86755(LY-458545 | LY 458545)
Affinity DataKi:  1.69E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50060635((S)-5-Fluorowillardiine | CHEMBL123132 | Fluorowil...)
Affinity DataKi:  1.82E+3nMAssay Description:Displacement of [3H]kainate from human Ionotropic glutamate receptor ionotropic kainate 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50060634((S)-2-Amino-3-(3,5-dioxo-4,5-dihydro-3H-[1,2,4]tri...)
Affinity DataKi:  1.98E+3nMAssay Description:Displacement of [3H]kainate from human Ionotropic glutamate receptor ionotropic kainate 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM17662(CHEMBL276815 | 2-amino-3-(3-hydroxy-5-methyl-4-iso...)
Affinity DataKi:  2.14E+3nMAssay Description:Displacement of [3H]kainate from human Ionotropic glutamate receptor ionotropic kainate 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM86752(LY-294486 | LY 294486)
Affinity DataKi:  3.06E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM86750(LY-302679 | LY 302679)
Affinity DataKi:  3.41E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50168962(LY 382884 | CHEMBL274226 | 6-(4-Carboxy-benzyl)-de...)
Affinity DataKi:  4.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM86751(CHEMBL14935 | LY-293558 | LY 293558)
Affinity DataKi:  4.20E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM86756(LY-467711 | LY 467711)
Affinity DataKi:  7.40E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50091474(LY-339637 | (2S,4E)-2-amino-4-(2-methylpropylidene...)
Affinity DataKi:  7.50E+3nMAssay Description:Binding affinity of compound was determined against KA2 using cell membranes prepared from HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50200526(CHEMBL1234118)
Affinity DataKi:  8.90E+3nMAssay Description:Displacement of [3H]-kainate from human recombinant GluK5 receptor expressed in HEK293 cell membranes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/28/2018
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50116046([7-(3-Aminomethyl-pyrrol-1-yl)-6-nitro-2,3-dioxo-3...)
Affinity DataKi:  9.80E+3nMAssay Description:Binding affinity towards Kai-2 using [3]H-kainate as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50088197(E-2-Amino-4-[3-(4-chloro-phenyl)-allyl]-pentanedio...)
Affinity DataKi: >1.00E+4nMAssay Description:Ability to bind to Ionotropic glutamate receptor kainate (kainate 2) was evaluated.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50091477((S)-2-Amino-4-cyclopentylidene-pentanedioic acid |...)
Affinity DataKi:  1.00E+4nMAssay Description:Binding affinity of compound was determined against KA2 using cell membranes prepared from HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50088216(LY-339296 | E-2-Amino-4-[3-(2-methoxy-phenyl)-ally...)
Affinity DataKi: >1.00E+4nMAssay Description:Compound was tested for binding affinity against Ionotropic glutamate receptor kainate (KA2) in HK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50088222(LY-339434 | (2S,4R)-2-Amino-4-((E)-3-naphthalen-2-...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity of compound was determined against KA2 using cell membranes prepared from HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50088222(LY-339434 | (2S,4R)-2-Amino-4-((E)-3-naphthalen-2-...)
Affinity DataKi: >1.00E+4nMAssay Description:Ability to bind to Ionotropic glutamate receptor kainate (kainate 2) was evaluated.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM86753(LY-525327 | LY 525327)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50116050(1-(4-Carboxymethyl-7-nitro-2,3-dioxo-1,2,3,4-tetra...)
Affinity DataKi:  1.10E+4nMAssay Description:Binding affinity towards Kai-2 using [3]H-kainate as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50116040((7-{3-[3-(4-Nitro-phenyl)-ureidomethyl]-pyrrol-1-y...)
Affinity DataKi:  1.20E+4nMAssay Description:Binding affinity towards Kai-2 using [3]H-kainate as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50116044({6-Nitro-2,3-dioxo-7-[3-(4-phenyl-piperidin-1-ylme...)
Affinity DataKi:  1.80E+4nMAssay Description:Binding affinity towards cloned human Kai-2 subunit stably expressed in cultured HEK293 cells using [3]H-kainate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50116042({7-[3-(4-Benzyl-piperazin-1-ylmethyl)-pyrrol-1-yl]...)
Affinity DataKi:  2.00E+4nMAssay Description:Binding affinity towards cloned human Kai-2 subunit stably expressed in cultured HEK293 cells using [3]H-kainate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50116047((6-Nitro-2,3-dioxo-7-{3-[(3-phenyl-propylamino)-me...)
Affinity DataKi:  2.00E+4nMAssay Description:Binding affinity towards cloned human Kai-2 subunit stably expressed in cultured HEK293 cells using [3]H-kainate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50091473(LY-339687 | (S)-2-Amino-4-(1-ethyl-propylidene)-pe...)
Affinity DataKi:  2.14E+4nMAssay Description:Binding affinity of compound was determined against KA2 using cell membranes prepared from HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50116043(3-(6-Nitro-2,3-dioxo-7-pyrrol-1-yl-3,4-dihydro-2H-...)
Affinity DataKi:  2.50E+4nMAssay Description:Binding affinity towards cloned human Kai-2 subunit stably expressed in cultured HEK293 cells using [3]H-kainate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50116048({6-Nitro-2,3-dioxo-7-[3-(4-phenethyl-piperazin-1-y...)
Affinity DataKi:  2.50E+4nMAssay Description:Binding affinity towards cloned human Kai-2 subunit stably expressed in cultured HEK293 cells using [3]H-kainate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50591738(CHEMBL5193862)
Affinity DataKi:  2.64E+4nMAssay Description:Binding affinity to GluK5 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM17661((2S)-2-amino-3-(2,4-dioxo-1,2,3,4-tetrahydropyrimi...)
Affinity DataKi:  2.89E+4nMAssay Description:Displacement of [3H]kainate from human Ionotropic glutamate receptor ionotropic kainate 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50116045(3-(7-{3-[(Benzyl-methyl-amino)-methyl]-pyrrol-1-yl...)
Affinity DataKi: >3.00E+4nMAssay Description:Binding affinity towards cloned human Kai-2 subunit stably expressed in cultured HEK293 cells using [3]H-kainate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 5(Human)
University of Bristol

Curated by ChEMBL
LigandPNGBDBM50116041([6-Nitro-2,3-dioxo-7-(3-piperidin-1-ylmethyl-pyrro...)
Affinity DataKi: >3.00E+4nMAssay Description:Binding affinity towards cloned human Kai-2 subunit stably expressed in cultured HEK293 cells using [3]H-kainate as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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