Compile Data Set for Download or QSAR
Report error Found 21 of affinity data for UniProtKB/TrEMBL: Q5T275
TargetKynurenine--oxoglutarate transaminase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50426341BDBM50426341(CHEMBL2321944)
Affinity DataIC50: 2.04E+3nMAssay Description:Inhibition of human KAT1 using L-kynurenine as substrate measured after 16 hrs by SpectraMax plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetKynurenine--oxoglutarate transaminase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50386310BDBM50386310(CHEMBL2049092)
Affinity DataIC50: 1.53E+4nMAssay Description:Inhibition of human KAT1 using L-kynurenine as substrate measured after 16 hrs by SpectraMax plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetKynurenine--oxoglutarate transaminase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50364911BDBM50364911(CHEMBL1950173)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant KAT1 after 20 mins by RP-HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetKynurenine--oxoglutarate transaminase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50364914BDBM50364914(CHEMBL1950178)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant KAT1 after 20 mins by RP-HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetKynurenine--oxoglutarate transaminase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50364910BDBM50364910(CHEMBL1950174)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of human recombinant KAT1 after 20 mins by RP-HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetKynurenine--oxoglutarate transaminase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50386292BDBM50386292(CHEMBL2047851)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of human KAT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetKynurenine--oxoglutarate transaminase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324539BDBM50324539((S)-(-)-9-(4-aminopiperazin-1-yl)-8-fluoro-3-methy...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human recombinant MBP-KAT1 expressed in HEK293 cells assessed as conversion of L-kynurenine to kynurenic acid after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetKynurenine--oxoglutarate transaminase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50324539BDBM50324539((S)-(-)-9-(4-aminopiperazin-1-yl)-8-fluoro-3-methy...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of KAT1 in human prefrontal cortex homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetKynurenine--oxoglutarate transaminase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50386292BDBM50386292(CHEMBL2047851)
Affinity DataIC50: 3.04E+4nMAssay Description:Inhibition of human KAT1 using L-kynurenine as substrate measured after 16 hrs by SpectraMax plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetKynurenine--oxoglutarate transaminase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50364912BDBM50364912(CHEMBL1950176)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human recombinant KAT1 after 20 mins by RP-HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetKynurenine--oxoglutarate transaminase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50364915BDBM50364915(CHEMBL1950179)
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of human recombinant KAT1 after 20 mins by RP-HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetKynurenine--oxoglutarate transaminase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50426340BDBM50426340(CHEMBL2321943)
Affinity DataIC50: 3.60E+4nMAssay Description:Inhibition of human KAT1 using L-kynurenine as substrate measured after 16 hrs by SpectraMax plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetKynurenine--oxoglutarate transaminase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50364913BDBM50364913(CHEMBL1950177)
Affinity DataIC50: 4.30E+4nMAssay Description:Inhibition of human recombinant KAT1 after 20 mins by RP-HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetKynurenine--oxoglutarate transaminase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 31879BDBM31879(Acid, 7 | 3-indolepropionic acid)
Affinity DataIC50: 1.40E+5nMpH: 7.5 T: 2°CAssay Description:A typical reaction mixture contains kynurenine, alpha-ketobutyrate, PLP and hKAT-I in the presence of test compound. The reaction mixture was incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2009
Entry Details Article
PubMed
TargetKynurenine--oxoglutarate transaminase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50364909BDBM50364909(CHEMBL1950175)
Affinity DataIC50: 1.79E+5nMAssay Description:Inhibition of human recombinant KAT1 after 20 mins by RP-HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetKynurenine--oxoglutarate transaminase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 31881BDBM31881(DL-indole-3-lactic acid)
Affinity DataIC50: 2.20E+5nMpH: 7.5 T: 2°CAssay Description:A typical reaction mixture contains kynurenine, alpha-ketobutyrate, PLP and hKAT-I in the presence of test compound. The reaction mixture was incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2009
Entry Details Article
PubMed
TargetKynurenine--oxoglutarate transaminase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50364916BDBM50364916(CHEMBL1950315)
Affinity DataIC50: 2.71E+5nMAssay Description:Inhibition of human recombinant KAT1 after 20 mins by RP-HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetKynurenine--oxoglutarate transaminase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50004956BDBM50004956(CHEMBL417544 | 3-(2-Carboxy-ethyl)-5-chloro-1H-ind...)
Affinity DataIC50: 2.93E+5nMAssay Description:Inhibition of human recombinant KAT1 after 20 mins by RP-HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetKynurenine--oxoglutarate transaminase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50364917BDBM50364917(CHEMBL1950316)
Affinity DataIC50: 6.66E+5nMAssay Description:Inhibition of human recombinant KAT1 after 20 mins by RP-HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetKynurenine--oxoglutarate transaminase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50364918BDBM50364918(CHEMBL1950317)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human recombinant KAT1 after 20 mins by RP-HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetKynurenine--oxoglutarate transaminase 1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50364919BDBM50364919(CHEMBL1508899)
Affinity DataIC50: 6.00E+6nMAssay Description:Inhibition of human recombinant KAT1 after 20 mins by RP-HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed