Compile Data Set for Download or QSAR
Report error Found 399 of affinity data for UniProtKB/TrEMBL: Q6GI75
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM16297(5-hexyl-2-phenoxyphenol | 5-Hexyl-2-phenoxy-phenol...)
Affinity DataKi:  0.0100nMpH: 7.5Assay Description:ThermoFluor experiments were carried out in 96-well plates (Concord) using the CFX96 RealTime PCR Detection system and C1000 Thermal Cycler (BioRad).More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI [9-251](Staphylococcus aureus)
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM97445(PT119)
Affinity DataKi:  0.0100nMAssay Description:Inhibition of Staphylococcus aureus enoyl ACP reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM97445(PT119)
Affinity DataKi:  0.0100nMpH: 7.5Assay Description:ThermoFluor experiments were carried out in 96-well plates (Concord) using the CFX96 RealTime PCR Detection system and C1000 Thermal Cycler (BioRad).More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM16296(5-pentyl-2-phenoxylphenol | 5-Pentyl-2-phenoxy-phe...)
Affinity DataKi:  0.0400nMpH: 7.5Assay Description:ThermoFluor experiments were carried out in 96-well plates (Concord) using the CFX96 RealTime PCR Detection system and C1000 Thermal Cycler (BioRad).More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM8726(CHEMBL849 | TCL | 5-chloro-2-(2,4-dichlorophenoxy)...)
Affinity DataKi:  0.0500nMpH: 7.5Assay Description:ThermoFluor experiments were carried out in 96-well plates (Concord) using the CFX96 RealTime PCR Detection system and C1000 Thermal Cycler (BioRad).More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM97444(PT443)
Affinity DataKi:  0.0500nMpH: 7.5Assay Description:ThermoFluor experiments were carried out in 96-well plates (Concord) using the CFX96 RealTime PCR Detection system and C1000 Thermal Cycler (BioRad).More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2013
Entry Details Article
PubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM36540(PT103 | 5-bromo-2-phenoxylphenol)
Affinity DataKi:  0.0600nMpH: 7.5Assay Description:ThermoFluor experiments were carried out in 96-well plates (Concord) using the CFX96 RealTime PCR Detection system and C1000 Thermal Cycler (BioRad).More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2013
Entry Details Article
PubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM97443(PT447)
Affinity DataKi:  0.0600nMpH: 7.5Assay Description:ThermoFluor experiments were carried out in 96-well plates (Concord) using the CFX96 RealTime PCR Detection system and C1000 Thermal Cycler (BioRad).More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2013
Entry Details Article
PubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM36543(PT02 | 5-propyl-2-phenoxyphenol)
Affinity DataKi:  0.0700nMpH: 7.5Assay Description:ThermoFluor experiments were carried out in 96-well plates (Concord) using the CFX96 RealTime PCR Detection system and C1000 Thermal Cycler (BioRad).More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM16294(PT01 | AIDS227443 | 5-butyl-2-phenoxylphenol | 5-e...)
Affinity DataKi:  0.0900nMpH: 7.5Assay Description:ThermoFluor experiments were carried out in 96-well plates (Concord) using the CFX96 RealTime PCR Detection system and C1000 Thermal Cycler (BioRad).More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM16294(PT01 | AIDS227443 | 5-butyl-2-phenoxylphenol | 5-e...)
Affinity DataKi:  0.0900nM ΔG°:  -57.3kJ/molepH: 7.5 T: 2°CAssay Description:10 μM saFabI, 15 μM inhibitor, and 500 μM NADPH were preincubated overnight at room temperature followed by a 1:200 dilution into reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM36539(PT52 | 5-chloro-2-phenoxylphenol | US10071965, Com...)
Affinity DataKi:  0.100nM ΔG°:  -57.1kJ/molepH: 7.5 T: 2°CAssay Description:10 μM saFabI, 15 μM inhibitor, and 500 μM NADPH were preincubated overnight at room temperature followed by a 1:200 dilution into reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM97441(PT89)
Affinity DataKi:  0.100nMpH: 7.5Assay Description:ThermoFluor experiments were carried out in 96-well plates (Concord) using the CFX96 RealTime PCR Detection system and C1000 Thermal Cycler (BioRad).More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2013
Entry Details Article
PubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM97440(PT68)
Affinity DataKi:  0.110nMpH: 7.5Assay Description:ThermoFluor experiments were carried out in 96-well plates (Concord) using the CFX96 RealTime PCR Detection system and C1000 Thermal Cycler (BioRad).More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM36539(PT52 | 5-chloro-2-phenoxylphenol | US10071965, Com...)
Affinity DataKi:  0.120nMpH: 7.5Assay Description:ThermoFluor experiments were carried out in 96-well plates (Concord) using the CFX96 RealTime PCR Detection system and C1000 Thermal Cycler (BioRad).More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM50373348(CHEMBL264434 | PT13)
Affinity DataKi:  0.120nMpH: 7.5Assay Description:ThermoFluor experiments were carried out in 96-well plates (Concord) using the CFX96 RealTime PCR Detection system and C1000 Thermal Cycler (BioRad).More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM16294(PT01 | AIDS227443 | 5-butyl-2-phenoxylphenol | 5-e...)
Affinity DataKi:  0.200nM ΔG°:  -55.4kJ/molepH: 7.5 T: 2°CAssay Description:10 μM saFabI, 15 μM inhibitor, and 500 μM NADPH were preincubated overnight at room temperature followed by a 1:200 dilution into reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM16294(PT01 | AIDS227443 | 5-butyl-2-phenoxylphenol | 5-e...)
Affinity DataKi:  0.200nM ΔG°:  -55.4kJ/molepH: 7.5 T: 2°CAssay Description:10 μM saFabI, 15 μM inhibitor, and 500 μM NADPH were preincubated overnight at room temperature followed by a 1:200 dilution into reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM50481806(CHEMBL5269135)
Affinity DataIC50: 0.310nMAssay Description:Inhibition of Staphylococcus aureus FabI assessed as inhibition of bacterial growth by measuring the NADH consumption rate at 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM50481809(CHEMBL5268904)
Affinity DataIC50: 0.330nMAssay Description:Inhibition of Staphylococcus aureus FabI assessed as inhibition of bacterial growth by measuring the NADH consumption rate at 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM50481808(CHEMBL5273284)
Affinity DataIC50: 0.350nMAssay Description:Inhibition of Staphylococcus aureus FabI assessed as inhibition of bacterial growth by measuring the NADH consumption rate at 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM50481807(CHEMBL5291446)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of Staphylococcus aureus FabI assessed as inhibition of bacterial growth by measuring the NADH consumption rate at 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM36542(PT53 | 5-methyl-2-phenoxylphenol | US10071965, Com...)
Affinity DataKi:  0.380nMpH: 7.5Assay Description:ThermoFluor experiments were carried out in 96-well plates (Concord) using the CFX96 RealTime PCR Detection system and C1000 Thermal Cycler (BioRad).More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM36542(PT53 | 5-methyl-2-phenoxylphenol | US10071965, Com...)
Affinity DataKi:  0.380nM ΔG°:  -53.8kJ/molepH: 7.5 T: 2°CAssay Description:10 μM saFabI, 15 μM inhibitor, and 500 μM NADPH were preincubated overnight at room temperature followed by a 1:200 dilution into reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM97446(PT162)
Affinity DataKi:  0.5nMpH: 7.5Assay Description:ThermoFluor experiments were carried out in 96-well plates (Concord) using the CFX96 RealTime PCR Detection system and C1000 Thermal Cycler (BioRad).More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2013
Entry Details Article
PubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM16298(5-Octyl-2-phenoxy-phenol | PT05 | CHEMBL505886 | 5...)
Affinity DataKi:  0.820nMpH: 7.5Assay Description:ThermoFluor experiments were carried out in 96-well plates (Concord) using the CFX96 RealTime PCR Detection system and C1000 Thermal Cycler (BioRad).More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2013
Entry Details Article
PubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM97442(PT446)
Affinity DataKi:  1.01nMpH: 7.5Assay Description:ThermoFluor experiments were carried out in 96-well plates (Concord) using the CFX96 RealTime PCR Detection system and C1000 Thermal Cycler (BioRad).More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2013
Entry Details Article
PubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM36538(PT55 | 5-fluoro-2-phenoxylphenol | US10071965, Com...)
Affinity DataKi:  1.10nM ΔG°:  -51.1kJ/molepH: 7.5 T: 2°CAssay Description:10 μM saFabI, 15 μM inhibitor, and 500 μM NADPH were preincubated overnight at room temperature followed by a 1:200 dilution into reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM231620(CG400549 | US10071965, Compound CG400549)
Affinity DataKi:  1.30nM ΔG°:  -50.7kJ/molepH: 7.5 T: 2°CAssay Description:10 μM saFabI, 15 μM inhibitor, and 500 μM NADPH were preincubated overnight at room temperature followed by a 1:200 dilution into reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM36538(PT55 | 5-fluoro-2-phenoxylphenol | US10071965, Com...)
Affinity DataKi:  1.42nMpH: 7.5Assay Description:ThermoFluor experiments were carried out in 96-well plates (Concord) using the CFX96 RealTime PCR Detection system and C1000 Thermal Cycler (BioRad).More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM36541(PT104 | 5-nitro-2-phenoxylphenol)
Affinity DataKi:  1.49nMpH: 7.5Assay Description:ThermoFluor experiments were carried out in 96-well plates (Concord) using the CFX96 RealTime PCR Detection system and C1000 Thermal Cycler (BioRad).More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2013
Entry Details Article
PubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM275883(US10071965, Compound PT173)
Affinity DataKi:  2nM ΔG°:  -49.7kJ/molepH: 7.5 T: 2°CAssay Description:10 μM saFabI, 15 μM inhibitor, and 500 μM NADPH were preincubated overnight at room temperature followed by a 1:200 dilution into reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM275889(US10071965, Compound PT166)
Affinity DataKi:  2.70nM ΔG°:  -48.9kJ/molepH: 7.5 T: 2°CAssay Description:10 μM saFabI, 15 μM inhibitor, and 500 μM NADPH were preincubated overnight at room temperature followed by a 1:200 dilution into reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM231620(CG400549 | US10071965, Compound CG400549)
Affinity DataKi:  4.70nMpH: 7.5Assay Description:Kinetics were performed on a Cary 100 spectrophotometer (Varian) at 20° C. Reaction velocities were measured by monitoring the oxidation of NAD(P)H t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM8726(CHEMBL849 | TCL | 5-chloro-2-(2,4-dichlorophenoxy)...)
Affinity DataKi:  5nMAssay Description:Inhibition of Staphylococcus aureus FabI in the presence of NADH using crotonyl CoA as substrate by measuring NADH consumption rateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM275889(US10071965, Compound PT166)
Affinity DataKi:  7nM ΔG°:  -46.5kJ/molepH: 7.5 T: 2°CAssay Description:10 μM saFabI, 15 μM inhibitor, and 500 μM NADPH were preincubated overnight at room temperature followed by a 1:200 dilution into reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM275883(US10071965, Compound PT173)
Affinity DataKi:  7.30nMpH: 7.5Assay Description:Kinetics were performed on a Cary 100 spectrophotometer (Varian) at 20° C. Reaction velocities were measured by monitoring the oxidation of NAD(P)H t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM50399411(CHEMBL2178304 | PT405)
Affinity DataIC50: 8nMAssay Description:Inhibition of Staphylococcus aureus recombinant FabI using trans-2-octenoyl N-acetylcysteamine thioester as substrate preincubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM275889(US10071965, Compound PT166)
Affinity DataKi:  8.5nMpH: 7.5Assay Description:Kinetics were performed on a Cary 100 spectrophotometer (Varian) at 20° C. Reaction velocities were measured by monitoring the oxidation of NAD(P)H t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM275889(US10071965, Compound PT166)
Affinity DataKi:  10.1nMpH: 7.5Assay Description:Kinetics were performed on a Cary 100 spectrophotometer (Varian) at 20° C. Reaction velocities were measured by monitoring the oxidation of NAD(P)H t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM275890(US10071965, Compound PT159)
Affinity DataKi:  11nM ΔG°:  -45.4kJ/molepH: 7.5 T: 2°CAssay Description:10 μM saFabI, 15 μM inhibitor, and 500 μM NADPH were preincubated overnight at room temperature followed by a 1:200 dilution into reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM275887(US10071965, Compound PT172)
Affinity DataKi:  11nM ΔG°:  -45.4kJ/molepH: 7.5 T: 2°CAssay Description:10 μM saFabI, 15 μM inhibitor, and 500 μM NADPH were preincubated overnight at room temperature followed by a 1:200 dilution into reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM275884(US10071965, Compound PT171)
Affinity DataKi:  11.9nM ΔG°:  -45.2kJ/molepH: 7.5 T: 2°CAssay Description:10 μM saFabI, 15 μM inhibitor, and 500 μM NADPH were preincubated overnight at room temperature followed by a 1:200 dilution into reac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM50399407(CHEMBL2178284 | MUT056399)
Affinity DataIC50: 12nMAssay Description:Inhibition of Staphylococcus aureus recombinant FabI using trans-2-octenoyl N-acetylcysteamine thioester as substrate preincubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM50399407(CHEMBL2178284 | MUT056399)
Affinity DataIC50: 12nMAssay Description:Inhibition of Staphylococcus aureus FabI in the presence of NADH using crotonyl CoA as substrate by measuring NADH consumption rateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM50399407(CHEMBL2178284 | MUT056399)
Affinity DataIC50: 12nMAssay Description:Inhibition of Staphylococcus aureus ATCC 29213 FabI in the presence of NADH using crotonyl CoA as substrate by measuring NADH consumption rateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM50399400(CHEMBL2178291)
Affinity DataIC50: 13nMAssay Description:Inhibition of Staphylococcus aureus recombinant FabI using trans-2-octenoyl N-acetylcysteamine thioester as substrate preincubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM133668(US8846711, 12 | US9051321, 12)
Affinity DataIC50: 13nMpH: 6.5 T: 2°CAssay Description:Compound inhibitory activity of FabI enzyme is measured in vitro by the IC5 so determination using a fluorescence based assay.The protein FabI from S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2015
Entry Details
US Patent

TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM50052244(CHEMBL1652621 | US20240190872, Compound Debio-1452)
Affinity DataIC50: 14nMAssay Description:Inhibition of Staphylococcus aureus FabI assessed as inhibition of bacterial growth by measuring the NADH consumption rate at 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus (strain MRSA252))
Stony Brook University

LigandPNGBDBM50481108(CHEMBL566665)
Affinity DataIC50: 14nMAssay Description:Inhibition of Staphylococcus aureus FabIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
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