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TargetTransient receptor potential cation channel subfamily A member 1(Rattus norvegicus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM161012(US9108905, 1 | US9186360, 89)
Affinity DataIC50: 0.101nMAssay Description:Antagonist activity at GFP-tagged rat TRPA1 transfected in HEK293F cells assessed as reduction in AITC-induced inward current at -60 mV holding poten...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Rattus norvegicus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM161012(US9108905, 1 | US9186360, 89)
Affinity DataIC50: 0.289nMAssay Description:Antagonist activity at rat TRPA1 expressed in HEK293F cells assessed as reduction in AITC-induced increase in intracellular Ca2+ level by FLIPR-based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM437915((2S)-3-(5-fluorobenzofuran-2- yl)sulfonyl-N-[[5-fl...)
Affinity DataIC50: 1.08nMAssay Description:IC50 (effective concentration) of compounds on the human and rat TRPA1 channels were determined using a FLIPR Tetra instrument. CHO cells expressing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2020
Entry Details
US Patent

LigandPNGBDBM437925((2S)-3-(4- fluorophenyl)sulfonyl-N-[[2- (trifluoro...)
Affinity DataIC50: 1.18nMAssay Description:IC50 (effective concentration) of compounds on the human and rat TRPA1 channels were determined using a FLIPR Tetra instrument. CHO cells expressing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2020
Entry Details
US Patent

LigandPNGBDBM437848((2S)-N-[[5-chloro-2-[2- (trifluoromethyl)pyrimidin...)
Affinity DataIC50: 1.55nMAssay Description:IC50 (effective concentration) of compounds on the human and rat TRPA1 channels were determined using a FLIPR Tetra instrument. CHO cells expressing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2020
Entry Details
US Patent

LigandPNGBDBM437932((2S)-3-(5-fluorobenzofuran-2- yl)sulfonyl-N-[[5- (...)
Affinity DataIC50: 1.85nMAssay Description:IC50 (effective concentration) of compounds on the human and rat TRPA1 channels were determined using a FLIPR Tetra instrument. CHO cells expressing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2020
Entry Details
US Patent

LigandPNGBDBM437842((2S)-N-[[2-cyclopropyl-6-[2- (trifluoromethyl)pyri...)
Affinity DataIC50: 2.15nMAssay Description:IC50 (effective concentration) of compounds on the human and rat TRPA1 channels were determined using a FLIPR Tetra instrument. CHO cells expressing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2020
Entry Details
US Patent

LigandPNGBDBM437894((2S)-3-(4- fluorophenyl)sulfonyl-N-[[5- (trifluoro...)
Affinity DataIC50: 2.61nMAssay Description:IC50 (effective concentration) of compounds on the human and rat TRPA1 channels were determined using a FLIPR Tetra instrument. CHO cells expressing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2020
Entry Details
US Patent

TargetTransient receptor potential cation channel subfamily A member 1(Rattus norvegicus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50638595(CHEMBL88169)
Affinity DataIC50: 2.70nMAssay Description:Antagonist activity at rat TRPA1 assessed as inhibition of capsaicin-induced increase in Ca2+ fluxMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM437854((2S)-3-(4- fluorophenyl)sulfonyl-N-[[5- (trifluoro...)
Affinity DataIC50: 2.77nMAssay Description:IC50 (effective concentration) of compounds on the human and rat TRPA1 channels were determined using a FLIPR Tetra instrument. CHO cells expressing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2020
Entry Details
US Patent

LigandPNGBDBM50362745(CHEMBL1939822)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at rat TRPA1 expressed in HEK293 cells assessed as inhibition of BITC-induced increase in intracellular calcium concentration by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
LigandPNGBDBM437955((2S)-N-[[2-cyclopropyl-6-[2- (trifluoromethyl)pyri...)
Affinity DataIC50: 3.55nMAssay Description:IC50 (effective concentration) of compounds on the human and rat TRPA1 channels were determined using a FLIPR Tetra instrument. CHO cells expressing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2020
Entry Details
US Patent

LigandPNGBDBM50318461(4-methyl-N-(2,2,2-trichloro-1-(4-chlorophenylthio)...)
Affinity DataEC50:  3.80nMAssay Description:Agonist activity at TRPA1 channel in rat DRG neurons assessed as increase in intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM437851((2S)-N-[[5-bromo-2-[2- (trifluoromethyl)pyrimidin-...)
Affinity DataIC50: 3.82nMAssay Description:IC50 (effective concentration) of compounds on the human and rat TRPA1 channels were determined using a FLIPR Tetra instrument. CHO cells expressing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2020
Entry Details
US Patent

LigandPNGBDBM50362741(CHEMBL1939826)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at rat TRPA1 expressed in HEK293 cells assessed as inhibition of BITC-induced increase in intracellular calcium concentration by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
LigandPNGBDBM50318462(4-methyl-N-(2,2,2-trichloro-1-(4-nitrophenylthio)e...)
Affinity DataEC50:  4nMAssay Description:Agonist activity at TRPA1 channel in rat DRG neurons assessed as increase in intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM437976((2S)-3-(4- fluorophenyl)sulfonyl-N-[[2- (2,2,2-tri...)
Affinity DataIC50: 4.24nMAssay Description:IC50 (effective concentration) of compounds on the human and rat TRPA1 channels were determined using a FLIPR Tetra instrument. CHO cells expressing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2020
Entry Details
US Patent

LigandPNGBDBM437802((2S)-N-[[2-chloro-6-[2- (trifluoromethyl)pyrimidin...)
Affinity DataIC50: 4.64nMAssay Description:IC50 (effective concentration) of compounds on the human and rat TRPA1 channels were determined using a FLIPR Tetra instrument. CHO cells expressing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2020
Entry Details
US Patent

LigandPNGBDBM437920((2S)-3-(4- fluorophenyl)sulfonyl-N-[[3- (trifluoro...)
Affinity DataIC50: 4.84nMAssay Description:IC50 (effective concentration) of compounds on the human and rat TRPA1 channels were determined using a FLIPR Tetra instrument. CHO cells expressing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2020
Entry Details
US Patent

LigandPNGBDBM437862((2S)-3-(4- fluorophenyl)sulfonyl-N-[[2- fluoro-5-[...)
Affinity DataIC50: 6.06nMAssay Description:IC50 (effective concentration) of compounds on the human and rat TRPA1 channels were determined using a FLIPR Tetra instrument. CHO cells expressing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2020
Entry Details
US Patent

LigandPNGBDBM437845((2S)-N-[[5-chloro-4-[2- (trifluoromethyl)pyrimidin...)
Affinity DataIC50: 6.08nMAssay Description:IC50 (effective concentration) of compounds on the human and rat TRPA1 channels were determined using a FLIPR Tetra instrument. CHO cells expressing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2020
Entry Details
US Patent

LigandPNGBDBM437886((2S)-3-(4- fluorophenyl)sulfonyl-N-[[3- fluoro-5-[...)
Affinity DataIC50: 6.11nMAssay Description:IC50 (effective concentration) of compounds on the human and rat TRPA1 channels were determined using a FLIPR Tetra instrument. CHO cells expressing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2020
Entry Details
US Patent

TargetTransient receptor potential cation channel subfamily A member 1(Rattus norvegicus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50318463(2-(1,3-dimethyl-2,6-dioxo-2,3-dihydro-1H-purin-7(6...)
Affinity DataIC50: 6.90nMAssay Description:Antagonist activity at rat TRPA1 expressed in HEK293F cells assessed as reduction in AITC-induced increase in intracellular Ca2+ level by FLIPR-based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Rattus norvegicus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM452524(US10710994, Example 2 | US10710994, Example 36 | 1...)
Affinity DataIC50: 7nMAssay Description:Agonist activity at rat TRPA1 transfected in HEK293F cells assessed as increase in Ca2+ influx by FLIPR calcium assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM437935((2S)-N-[[6-cyclopropyl-4-[2- (trifluoromethyl)pyri...)
Affinity DataIC50: 7.24nMAssay Description:IC50 (effective concentration) of compounds on the human and rat TRPA1 channels were determined using a FLIPR Tetra instrument. CHO cells expressing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2020
Entry Details
US Patent

LigandPNGBDBM452523(US10710994, Example 1 | US10710994, Example 5 | US...)
Affinity DataIC50: 7.40nMAssay Description:Antagonist activity at rat TRPA1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
LigandPNGBDBM50573116(CHEMBL4870870)
Affinity DataIC50: 7.90nMAssay Description:Antagonist activity at rat TRPA1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
LigandPNGBDBM50254439(CHEMBL4091459)
Affinity DataIC50: 8nMAssay Description:Inhibition of full length rat TRPA1 at a holding potential of 15 mV measured after 1 min by PatchXpress electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2019
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Rattus norvegicus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50652931(CHEMBL5687035)
Affinity DataIC50: 8.80nMAssay Description:Antagonist activity at rat TRPA1 expressed in HEK293F cells assessed as reduction in AITC-induced increase in intracellular Ca2+ level by FLIPR-based...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM437885((2S)-3-(4- fluorophenyl)sulfonyl-N-[[3- fluoro-5-[...)
Affinity DataIC50: 8.97nMAssay Description:IC50 (effective concentration) of compounds on the human and rat TRPA1 channels were determined using a FLIPR Tetra instrument. CHO cells expressing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2020
Entry Details
US Patent

LigandPNGBDBM50254402(CHEMBL4098431)
Affinity DataIC50: 9nMAssay Description:Inhibition of full length rat TRPA1 at a holding potential of 15 mV measured after 1 min by PatchXpress electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2019
Entry Details Article
PubMed
LigandPNGBDBM50254442(CHEMBL4095993)
Affinity DataIC50: 9nMAssay Description:Inhibition of full length rat TRPA1 at a holding potential of 15 mV measured after 1 min by PatchXpress electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2019
Entry Details Article
PubMed
LigandPNGBDBM437908((2S)-N-[[5-(difluoromethyl)-2- [2-(trifluoromethyl...)
Affinity DataIC50: 9.01nMAssay Description:IC50 (effective concentration) of compounds on the human and rat TRPA1 channels were determined using a FLIPR Tetra instrument. CHO cells expressing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2020
Entry Details
US Patent

LigandPNGBDBM437855((2S)-3-(4- fluorophenyl)sulfonyl-N-[[2- fluoro-5-[...)
Affinity DataIC50: 9.89nMAssay Description:IC50 (effective concentration) of compounds on the human and rat TRPA1 channels were determined using a FLIPR Tetra instrument. CHO cells expressing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2020
Entry Details
US Patent

LigandPNGBDBM437896((2S)-N-[[5-(difluoromethyl)-2- [2-(trifluoromethyl...)
Affinity DataIC50: 9.92nMAssay Description:IC50 (effective concentration) of compounds on the human and rat TRPA1 channels were determined using a FLIPR Tetra instrument. CHO cells expressing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2020
Entry Details
US Patent

LigandPNGBDBM50157631(CHEMBL3785736)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at rat TRPA1 expressed in tetracycline-inducible T-REx expression system transfected CHO cells assessed as inhibition of hypo osm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2017
Entry Details Article
PubMed
LigandPNGBDBM50362764(CHEMBL1939833)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at rat TRPA1 expressed in HEK293 cells assessed as inhibition of BITC-induced increase in intracellular calcium concentration by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
LigandPNGBDBM50573115(CHEMBL4865238)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at rat TRPA1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
LigandPNGBDBM437913((2S)-3-(3,4- difluorophenyl)sulfonyl-N-[[5- fluoro...)
Affinity DataIC50: 10.6nMAssay Description:IC50 (effective concentration) of compounds on the human and rat TRPA1 channels were determined using a FLIPR Tetra instrument. CHO cells expressing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2020
Entry Details
US Patent

LigandPNGBDBM50362741(CHEMBL1939826)
Affinity DataIC50: 11nMAssay Description:Antagonist activity at rat TRPA1 expressed in HEK293 cells assessed as inhibition of BITC-induced increase in intracellular calcium concentration by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
LigandPNGBDBM50254387(CHEMBL4062193)
Affinity DataIC50: 11nMAssay Description:Inhibition of rat TRPA1 at a holding potential of 15 mV measured after 1 min by whole-cell manual patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2019
Entry Details Article
PubMed
LigandPNGBDBM50254387(CHEMBL4062193)
Affinity DataIC50: 11nMAssay Description:Inhibition of full length rat TRPA1 at a holding potential of 15 mV measured after 1 min by PatchXpress electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2019
Entry Details Article
PubMed
LigandPNGBDBM437790((2S)-3-(4- fluorophenyl)sulfonyl-N- [[5-fluoro-2-[...)
Affinity DataIC50: 11.3nMAssay Description:IC50 (effective concentration) of compounds on the human and rat TRPA1 channels were determined using a FLIPR Tetra instrument. CHO cells expressing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2020
Entry Details
US Patent

LigandPNGBDBM50362768(CHEMBL1939828)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at rat TRPA1 expressed in HEK293 cells assessed as inhibition of BITC-induced increase in intracellular calcium concentration by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
LigandPNGBDBM437917((2S)-3-(4- fluorophenyl)sulfonyl-N-[[2- (trifluoro...)
Affinity DataIC50: 12.1nMAssay Description:IC50 (effective concentration) of compounds on the human and rat TRPA1 channels were determined using a FLIPR Tetra instrument. CHO cells expressing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2020
Entry Details
US Patent

LigandPNGBDBM50036952(CHEMBL3355293)
Affinity DataIC50: 13nMAssay Description:Antagonist activity against rat TRPA1 expressed in HEK293 cells assessed as inhibition of AITC-induced increase in intracellular Ca2+ concentration b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2016
Entry Details Article
PubMed
LigandPNGBDBM481808(3-[3-(4- chlorophenyl)cyclobutyl]-5- [(7-methyl-6-...)
Affinity DataIC50: 14nMAssay Description:Antagonist activity at rat TRPA1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
LigandPNGBDBM50318460(S-2,2,2-trichloro-1-(4-chlorobenzamido)ethyl ethan...)
Affinity DataEC50:  15nMAssay Description:Agonist activity at TRPA1 channel in rat DRG neurons assessed as increase in intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM437881((2S)-N-[[2-fluoro-5-[2-methyl- 5-(trifluoromethyl)...)
Affinity DataIC50: 15.7nMAssay Description:IC50 (effective concentration) of compounds on the human and rat TRPA1 channels were determined using a FLIPR Tetra instrument. CHO cells expressing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2020
Entry Details
US Patent

LigandPNGBDBM437837((2S)-N-[[5-cyano-2-[2- (trifluoromethyl)pyrimidin-...)
Affinity DataIC50: 16nMAssay Description:IC50 (effective concentration) of compounds on the human and rat TRPA1 channels were determined using a FLIPR Tetra instrument. CHO cells expressing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2020
Entry Details
US Patent

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