Compile Data Set for Download or QSAR
Report error Found 42 of affinity data for UniProtKB/TrEMBL: Q8BLA8
LigandPNGBDBM161012(US9108905, 1 | US9186360, 89)
Affinity DataIC50: 0.296nMAssay Description:Antagonist activity at mouse TRPA1 expressed in HEK293F cells assessed as reduction in AITC-induced increase in intracellular Ca2+ level by FLIPR-bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50022322(CHEMBL3298923)
Affinity DataIC50: 53nMAssay Description:Antagonist activity at mouse TRPA1 expressed in CHO-TREX cells assessed as inhibition of cinnamaldehyde-induced calcium flux incubated 10 mins prior ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
LigandPNGBDBM50022321(CHEMBL3298922)
Affinity DataIC50: 94nMAssay Description:Antagonist activity at mouse TRPA1 expressed in CHO-TREX cells assessed as inhibition of cinnamaldehyde-induced calcium flux incubated 10 mins prior ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
LigandPNGBDBM50022347(CHEMBL3299022)
Affinity DataIC50: 104nMAssay Description:Antagonist activity at mouse TRPA1 expressed in CHO-TREX cells assessed as inhibition of cinnamaldehyde-induced calcium flux incubated 10 mins prior ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
LigandPNGBDBM50022327(CHEMBL3299019)
Affinity DataIC50: 161nMAssay Description:Antagonist activity at mouse TRPA1 expressed in CHO-TREX cells assessed as inhibition of cinnamaldehyde-induced calcium flux incubated 10 mins prior ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
LigandPNGBDBM50022307(CHEMBL3298242)
Affinity DataIC50: 252nMAssay Description:Antagonist activity at mouse TRPA1 expressed in CHO-TREX cells assessed as inhibition of cinnamaldehyde-induced calcium flux incubated 10 mins prior ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
LigandPNGBDBM50022349(CHEMBL3299024)
Affinity DataIC50: 254nMAssay Description:Antagonist activity at mouse TRPA1 expressed in CHO-TREX cells assessed as inhibition of cinnamaldehyde-induced calcium flux incubated 10 mins prior ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMed
LigandPNGBDBM50336640((nifedipine) 2,6-Dimethyl-4-(2-nitro-phenyl)-1,4-d...)
Affinity DataEC50:  400nMAssay Description:Agonist activity at mouse TRPA1 channel expressed in CHO cells assessed as increase in intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50367298(Cardene | NICARDIPINE)
Affinity DataEC50:  500nMAssay Description:Agonist activity at mouse TRPA1 channel expressed in CHO cells assessed as increase in intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM161012(US9108905, 1 | US9186360, 89)
Affinity DataIC50: 750nMAssay Description:Antagonist activity at full length mouse TRPA1 transfected in HEK293F cells assessed as blockade of MO-induced TRPA1 channel activation by measuring ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50318493(Nimotop | 3-isopropyl 5-(2-methoxyethyl) 2,6-dimet...)
Affinity DataEC50:  800nMAssay Description:Agonist activity at mouse TRPA1 channel expressed in CHO cells assessed as increase in intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318462(4-methyl-N-(2,2,2-trichloro-1-(4-nitrophenylthio)e...)
Affinity DataEC50:  930nMAssay Description:Agonist activity at full length mouse TRPA1 transfected in HEK293F cells assessed as increase in Ca2+ influx by FLIPR calcium assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50240948(S-allyl prop-2-ene-1-sulfinothioate | allicin | th...)
Affinity DataEC50:  1.32E+3nMAssay Description:Activation of mouse TRPA1 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM61009(cid_37839 | Isovelleral | marasmane | (1aS,3aS,6aS...)
Affinity DataEC50:  2.58E+3nMAssay Description:Agonist activity at mouse TRPA1 channel expressed in HEK293 cells assessed as increase in intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50203065(3-phenylprop-2-enal | cinnamaldehyde | 3-phenylacr...)
Affinity DataEC50:  3.40E+3nMAssay Description:Agonist activity at full length mouse TRPA1 transfected in HEK293F cells assessed as increase in Ca2+ influx by FLIPR calcium assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50318494(3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,...)
Affinity DataEC50:  3.80E+3nMAssay Description:Agonist activity at mouse TRPA1 channel expressed in CHO cells assessed as increase in intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50305207(4-(4-chlorophenyl)-3-methylbut-3-en-2-one oxime | ...)
Affinity DataIC50: 4.50E+3nMAssay Description:Antagonist activity at mouse TRPA1 channel expressed in CHO cells assessed as inhibition of cinnamaldehyde-induced intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM248162(Menthol)
Affinity DataEC50:  5.20E+3nMAssay Description:Agonist activity at full length mouse TRPA1 transfected in HEK293F cells assessed as increase in Ca2+ influx by FLIPR calcium assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50242402(4-Hydroxynonenal | 4-hydroxy-2-nonenal | CHEMBL454...)
Affinity DataEC50:  6.60E+3nMAssay Description:Agonist activity at full length mouse TRPA1 transfected in HEK293F cells assessed as increase in Ca2+ influx by FLIPR calcium assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50318463(2-(1,3-dimethyl-2,6-dioxo-2,3-dihydro-1H-purin-7(6...)
Affinity DataIC50: 6.80E+3nMAssay Description:Antagonist activity at full length mouse TRPA1 transfected in HEK293F cells assessed as blockade of MO-induced TRPA1 channel activation by measuring ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataEC50:  1.00E+4nMAssay Description:Agonist activity at mouse TRPA1 expressed in CHO cells assessed as increase in calcium influx by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
LigandPNGBDBM50318496((R)-methyl 2,6-dimethyl-5-nitro-4-(2-(trifluoromet...)
Affinity DataEC50:  2.08E+4nMAssay Description:Agonist activity at mouse TRPA1 channel expressed in CHO cells assessed as increase in intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50203072(Allylisothiocyanate | 3-isothiocyanatoprop-1-ene |...)
Affinity DataEC50:  2.20E+4nMAssay Description:Agonist activity at mouse TRPA1 expressed in CHO cells assessed as increase in calcium influx by Fluo-3 based FLIPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
LigandPNGBDBM34612(SMR000048831 | MLS000047780 | 2-methylnaphtho[2,1-...)
Affinity DataEC50:  3.02E+4nMAssay Description:Agonist activity at full length mouse TRPA1 transfected in HEK293F cells assessed as increase in Ca2+ influx by FLIPR calcium assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50318495(Bay k 8644 | CHEMBL1082832 | methyl 2,6-dimethyl-5...)
Affinity DataEC50:  3.27E+4nMAssay Description:Agonist activity at mouse TRPA1 channel expressed in CHO cells assessed as increase in intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50305207(4-(4-chlorophenyl)-3-methylbut-3-en-2-one oxime | ...)
Affinity DataIC50: 3.30E+4nMAssay Description:Antagonist activity at full length mouse TRPA1 transfected in HEK293F cells assessed as blockade of MO-induced TRPA1 channel activation by measuring ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50318497((S)-methyl 2,6-dimethyl-5-nitro-4-(2-(trifluoromet...)
Affinity DataEC50:  4.15E+4nMAssay Description:Agonist activity at mouse TRPA1 channel expressed in CHO cells assessed as increase in intracellular calcium influxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50441016((Z)-Ligustilide | CHEMBL481246)
Affinity DataEC50:  4.40E+4nMAssay Description:Antagonist activity at mouse TRPA1 expressed in HEK293F cells as increase in Ca2+ influx by FLIPR calcium assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50318482(CHEMBL470670 | l-menthol | (-)-menthol | MENTHOL |...)
Affinity DataEC50:  5.60E+4nMAssay Description:Antagonist activity at mouse TRPA1 channel expressed in CHO cells assessed as blockade of agonist-induced whole cell conductance by electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50270612(15-deoxy-d12,14-prostaglandin J2 | 15-deoxy-delta1...)
Affinity DataEC50:  5.64E+4nMAssay Description:Agonist activity at full length mouse TRPA1 transfected in HEK293F cells assessed as increase in Ca2+ influx by FLIPR calcium assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50203065(3-phenylprop-2-enal | cinnamaldehyde | 3-phenylacr...)
Affinity DataEC50:  6.10E+4nMAssay Description:Agonist activity at mouse TRPA1 expressed in CHO cells assessed as increase in calcium influx by Fluo-3 based FLIPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
LigandPNGBDBM10849(CHEMBL113 | 1,3,7-trimethyl-3,7-dihydropurine-2,6-...)
Affinity DataEC50:  6.18E+4nMAssay Description:Agonist activity at full length mouse TRPA1 transfected in HEK293F cells assessed as increase in Ca2+ influx by FLIPR calcium assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM26739(URB 597 | URB597 | CHEMBL184238 | 3-(3-carbamoylph...)
Affinity DataEC50:  7.44E+4nMAssay Description:Agonist activity at full length mouse TRPA1 transfected in HEK293F cells assessed as increase in Ca2+ influx by FLIPR calcium assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50034278(2-((2E,6E)-3,7,11-Trimethyl-dodeca-2,6,10-trienyls...)
Affinity DataEC50:  8.55E+4nMAssay Description:Agonist activity at full length mouse TRPA1 transfected in HEK293F cells assessed as increase in Ca2+ influx by FLIPR calcium assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM248162(Menthol)
Affinity DataEC50:  9.50E+4nMAssay Description:Agonist activity at mouse TRPA1 expressed in CHO cells assessed as increase in calcium influx by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
LigandPNGBDBM61009(cid_37839 | Isovelleral | marasmane | (1aS,3aS,6aS...)
Affinity DataEC50:  1.30E+5nMAssay Description:Agonist activity at TRPA1 channel in mouse dorsal root ganglion cells assessed as increase in intracellular calcium influx by radiometric Ca2+ imagin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50650151(CHEMBL5630743)
Affinity DataEC50:  4.22E+5nMAssay Description:Agonist activity at full length mouse TRPA1 transfected in HEK293F cells assessed as increase in Ca2+ influx by FLIPR calcium assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50650152(CHEMBL4519263)
Affinity DataEC50:  5.10E+5nMAssay Description:Agonist activity at full length mouse TRPA1 transfected in HEK293F cells assessed as increase in Ca2+ influx by FLIPR calcium assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50241315(Z-butylidenephthalide | (Z)-3-butylideneisobenzofu...)
Affinity DataEC50:  5.39E+5nMAssay Description:Agonist activity at full length mouse TRPA1 transfected in HEK293F cells assessed as increase in Ca2+ influx by FLIPR calcium assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM248162(Menthol)
Affinity DataIC50: 9.51E+5nMAssay Description:Antagonist activity at full length mouse TRPA1 transfected in HEK293F cells assessed as blockade of MO-induced TRPA1 channel activation by measuring ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM50318463(2-(1,3-dimethyl-2,6-dioxo-2,3-dihydro-1H-purin-7(6...)
Affinity DataEC50:  1.00E+6nMAssay Description:Activation of mouse TRPA1 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
LigandPNGBDBM50318464(N-(4-sec-butylphenyl)-2-(1,3-dimethyl-2,6-dioxo-2,...)
Affinity DataEC50:  2.50E+6nMAssay Description:Activation of mouse TRPA1 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed