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TargetTargeting protein for Xklp2(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50648058(CHEMBL5598235)
Affinity DataKd:  18nMAssay Description:Inhibition of 6-His-tagged human Aurora A (126 to 390 residues) expressed in Escherichia coli BL21 (DE3) cells/N-terminal his-tagged/GB-1 fused human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTargeting protein for Xklp2(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50648059(CHEMBL5597404)
Affinity DataKd:  19nMAssay Description:Inhibition of 6-His-tagged human Aurora A (126 to 390 residues) expressed in Escherichia coli BL21 (DE3) cells/N-terminal his-tagged/GB-1 fused human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetAurora kinase A/Targeting protein for Xklp2(Human)
Nirma University

Curated by ChEMBL
LigandPNGBDBM209861(TAK-901 | 5-(3-ethylsulfonylphenyl)-3,8-dimethyl-N...)
Affinity DataIC50: 21nMAssay Description:Inhibition of Aurora A/TPX2 (unknown origin) pre-incubated for 1 hr followed by FL-Kemptide substrate and ATP additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTargeting protein for Xklp2(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50648057(CHEMBL5596916)
Affinity DataKd:  63nMAssay Description:Inhibition of 6-His-tagged human Aurora A (126 to 390 residues) expressed in Escherichia coli BL21 (DE3) cells/N-terminal his-tagged/GB-1 fused human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTargeting protein for Xklp2(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50648055(CHEMBL5596260)
Affinity DataKd:  79nMAssay Description:Inhibition of 6-His-tagged human Aurora A (126 to 390 residues) expressed in Escherichia coli BL21 (DE3) cells/N-terminal his-tagged/GB-1 fused human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTargeting protein for Xklp2(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50648056(CHEMBL5598288)
Affinity DataKd:  100nMAssay Description:Inhibition of 6-His-tagged human Aurora A (126 to 390 residues) expressed in Escherichia coli BL21 (DE3) cells/N-terminal his-tagged/GB-1 fused human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTargeting protein for Xklp2(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50648052(CHEMBL5598166)
Affinity DataKd:  158nMAssay Description:Inhibition of 6-His-tagged human Aurora A (126 to 390 residues) expressed in Escherichia coli BL21 (DE3) cells/N-terminal his-tagged/GB-1 fused human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTargeting protein for Xklp2(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50648054(CHEMBL5597168)
Affinity DataKd:  200nMAssay Description:Inhibition of 6-His-tagged human Aurora A (126 to 390 residues) expressed in Escherichia coli BL21 (DE3) cells/N-terminal his-tagged/GB-1 fused human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTargeting protein for Xklp2(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50315769(GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...)
Affinity DataKi:  490nMAssay Description:Inhibition of human Aurora A/TPX2 (unknown origin) pre-incubated for 30 mins before Biotin-Ahx-RARRRLSFFFFAKKK-NH2 substrate addition and measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTargeting protein for Xklp2(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50315769(GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...)
Affinity DataKi:  492nMAssay Description:Binding affinity to Aura/TPX2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTargeting protein for Xklp2(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50315769(GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...)
Affinity DataKi:  492nMAssay Description:Binding affinity to human AurA/TPX2 assessed as inhibition constant using aurora sox peptide as substrate incubated for 60 mins in presence of ATP by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTargeting protein for Xklp2(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50648053(CHEMBL5596300)
Affinity DataKd:  955nMAssay Description:Inhibition of 6-His-tagged human Aurora A (126 to 390 residues) expressed in Escherichia coli BL21 (DE3) cells/N-terminal his-tagged/GB-1 fused human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTargeting protein for Xklp2(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50315769(GSK-1070916 | 4-[3-(4-N,N-Dimethylcarbamylaminophe...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human AurA/TPX2 in PBS using Biotin-Ahx-RARRRLSFFFFAKKK-NH2 as substrate incubated for 30 mins in presence of ATP by LEADseeker assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTargeting protein for Xklp2(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50648051(CHEMBL5597558)
Affinity DataKd:  1.26E+3nMAssay Description:Inhibition of 6-His-tagged human Aurora A (126 to 390 residues) expressed in Escherichia coli BL21 (DE3) cells/N-terminal his-tagged/GB-1 fused human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTargeting protein for Xklp2(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50648057(CHEMBL5596916)
Affinity DataEC50:  1.30E+3nMAssay Description:Inhibition of Aurora A-TPX2 protein-protein interaction in human HeLa cells assessed as mislocalization of aurora A by measuring displacement from sp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetKinesin-like protein KIF15/Targeting protein for Xklp2(Human)
University of Kansas

US Patent
LigandPNGBDBM700780(6-(2-chlorobenzyl)-2-(4-ethylpiperazin-1-yl)-5,6,7...)
Affinity DataIC50: 1.50E+3nMAssay Description:An AlphaScreen-based high-throughput screening assay can be used to identify inhibitors of the KIF15-TPX2 protein-protein interaction. These inhibito...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

TargetKinesin-like protein KIF15/Targeting protein for Xklp2(Human)
University of Kansas

US Patent
LigandPNGBDBM700779(2-(4-ethylpiperazin-1-yl)-6-(2,3,4-trimethoxybenzy...)
Affinity DataIC50: 1.70E+3nMAssay Description:An AlphaScreen-based high-throughput screening assay can be used to identify inhibitors of the KIF15-TPX2 protein-protein interaction. These inhibito...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

TargetTargeting protein for Xklp2(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50648056(CHEMBL5598288)
Affinity DataEC50:  2.20E+3nMAssay Description:Inhibition of Aurora A-TPX2 protein-protein interaction in human HeLa cells assessed as mislocalization of aurora A by measuring displacement from sp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetKinesin-like protein KIF15/Targeting protein for Xklp2(Human)
University of Kansas

US Patent
LigandPNGBDBM700778(2-(4-ethylpiperazin-1-yl)-6-(2,4,5-trimethoxybenzy...)
Affinity DataIC50: 2.40E+3nMAssay Description:An AlphaScreen-based high-throughput screening assay can be used to identify inhibitors of the KIF15-TPX2 protein-protein interaction. These inhibito...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

TargetKinesin-like protein KIF15/Targeting protein for Xklp2(Human)
University of Kansas

US Patent
LigandPNGBDBM700781(2-(4-ethylpiperazin-1-yl)-6-(3,4,5-trimethoxybenzy...)
Affinity DataIC50: 2.50E+3nMAssay Description:An AlphaScreen-based high-throughput screening assay can be used to identify inhibitors of the KIF15-TPX2 protein-protein interaction. These inhibito...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

TargetKinesin-like protein KIF15/Targeting protein for Xklp2(Human)
University of Kansas

US Patent
LigandPNGBDBM700777(6-(3,4-diethoxybenzyl)-2-(4-ethylpiperazin-1-yl)-5...)
Affinity DataIC50: 2.80E+3nMAssay Description:An AlphaScreen-based high-throughput screening assay can be used to identify inhibitors of the KIF15-TPX2 protein-protein interaction. These inhibito...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

TargetTargeting protein for Xklp2(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50648055(CHEMBL5596260)
Affinity DataEC50:  3.50E+3nMAssay Description:Inhibition of Aurora A-TPX2 protein-protein interaction in human HeLa cells assessed as mislocalization of aurora A by measuring displacement from sp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetKinesin-like protein KIF15/Targeting protein for Xklp2(Human)
University of Kansas

US Patent
LigandPNGBDBM700782(6-(4-ethoxy-3-methoxybenzyl)-2-(4-ethylpiperazin-1...)
Affinity DataIC50: 3.50E+3nMAssay Description:An AlphaScreen-based high-throughput screening assay can be used to identify inhibitors of the KIF15-TPX2 protein-protein interaction. These inhibito...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

TargetTargeting protein for Xklp2(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50648059(CHEMBL5597404)
Affinity DataEC50:  3.90E+3nMAssay Description:Inhibition of Aurora A-TPX2 protein-protein interaction in human HeLa cells assessed as reduction in aurora A phosphorylation at Thr288 residue incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTargeting protein for Xklp2(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50648057(CHEMBL5596916)
Affinity DataEC50:  4.50E+3nMAssay Description:Inhibition of Aurora A-TPX2 protein-protein interaction in human HeLa cells assessed as reduction in aurora A phosphorylation at Thr288 residue incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTargeting protein for Xklp2(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50648054(CHEMBL5597168)
Affinity DataEC50:  5.50E+3nMAssay Description:Inhibition of Aurora A-TPX2 protein-protein interaction in human HeLa cells assessed as mislocalization of aurora A by measuring displacement from sp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetKinesin-like protein KIF15/Targeting protein for Xklp2(Human)
University of Kansas

US Patent
LigandPNGBDBM700784(4-allyl-2-methyl-N-(pyridin-2-ylmethyl)-4H-thieno[...)
Affinity DataIC50: 5.60E+3nMAssay Description:An AlphaScreen-based high-throughput screening assay can be used to identify inhibitors of the KIF15-TPX2 protein-protein interaction. These inhibito...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

TargetTargeting protein for Xklp2(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50648055(CHEMBL5596260)
Affinity DataEC50:  5.90E+3nMAssay Description:Inhibition of Aurora A-TPX2 protein-protein interaction in human HeLa cells assessed as reduction in aurora A phosphorylation at Thr288 residue incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTargeting protein for Xklp2(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50648059(CHEMBL5597404)
Affinity DataEC50:  6.10E+3nMAssay Description:Inhibition of Aurora A-TPX2 protein-protein interaction in human HeLa cells assessed as mislocalization of aurora A by measuring displacement from sp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTargeting protein for Xklp2(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50648054(CHEMBL5597168)
Affinity DataEC50:  6.40E+3nMAssay Description:Inhibition of Aurora A-TPX2 protein-protein interaction in human HeLa cells assessed as reduction in aurora A phosphorylation at Thr288 residue incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTargeting protein for Xklp2(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50648056(CHEMBL5598288)
Affinity DataEC50:  6.90E+3nMAssay Description:Inhibition of Aurora A-TPX2 protein-protein interaction in human HeLa cells assessed as reduction in aurora A phosphorylation at Thr288 residue incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTargeting protein for Xklp2(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of TPX2 (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetKinesin-like protein KIF15/Targeting protein for Xklp2(Human)
University of Kansas

US Patent
LigandPNGBDBM700776(6-(4-bromobenzyl)-2-(4-propylpiperazin-1-yl)-5,6,7...)
Affinity DataIC50: 1.36E+4nMAssay Description:An AlphaScreen-based high-throughput screening assay can be used to identify inhibitors of the KIF15-TPX2 protein-protein interaction. These inhibito...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

TargetTargeting protein for Xklp2(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50648053(CHEMBL5596300)
Affinity DataEC50:  2.00E+4nMAssay Description:Inhibition of Aurora A-TPX2 protein-protein interaction in human HeLa cells assessed as mislocalization of aurora A by measuring displacement from sp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetKinesin-like protein KIF15/Targeting protein for Xklp2(Human)
University of Kansas

US Patent
LigandPNGBDBM700775(6-(3-bromobenzyl)-2-(4-propylpiperazin-1-yl)-5,6,7...)
Affinity DataIC50: 2.10E+4nMAssay Description:An AlphaScreen-based high-throughput screening assay can be used to identify inhibitors of the KIF15-TPX2 protein-protein interaction. These inhibito...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

TargetTargeting protein for Xklp2(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50648053(CHEMBL5596300)
Affinity DataEC50:  2.18E+4nMAssay Description:Inhibition of Aurora A-TPX2 protein-protein interaction in human HeLa cells assessed as reduction in aurora A phosphorylation at Thr288 residue incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetKinesin-like protein KIF15/Targeting protein for Xklp2(Human)
University of Kansas

US Patent
LigandPNGBDBM700774(6-((5-bromothiophen-2-yl)methyl)-2-(4-propylpipera...)
Affinity DataIC50: 2.30E+4nMAssay Description:An AlphaScreen-based high-throughput screening assay can be used to identify inhibitors of the KIF15-TPX2 protein-protein interaction. These inhibito...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

TargetKinesin-like protein KIF15/Targeting protein for Xklp2(Human)
University of Kansas

US Patent
LigandPNGBDBM700772(6-(2,3-difluorobenzyl)-2-(4-propylpiperazin-1-yl)-...)
Affinity DataIC50: 2.78E+4nMAssay Description:An AlphaScreen-based high-throughput screening assay can be used to identify inhibitors of the KIF15-TPX2 protein-protein interaction. These inhibito...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

TargetKinesin-like protein KIF15/Targeting protein for Xklp2(Human)
University of Kansas

US Patent
LigandPNGBDBM700771(6-(4-ethylbenzyl)-2-(4-propylpiperazin-1-yl)-5,6,7...)
Affinity DataIC50: 3.22E+4nMAssay Description:An AlphaScreen-based high-throughput screening assay can be used to identify inhibitors of the KIF15-TPX2 protein-protein interaction. These inhibito...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

TargetKinesin-like protein KIF15/Targeting protein for Xklp2(Human)
University of Kansas

US Patent
LigandPNGBDBM700773(6-(3,4-diethoxybenzyl)-2-(4-propylpiperazin-1-yl)-...)
Affinity DataIC50: 4.22E+4nMAssay Description:An AlphaScreen-based high-throughput screening assay can be used to identify inhibitors of the KIF15-TPX2 protein-protein interaction. These inhibito...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

TargetKinesin-like protein KIF15/Targeting protein for Xklp2(Human)
University of Kansas

US Patent
LigandPNGBDBM700783(6-(4-ethoxy-3-methoxybenzyl)-2-(4-propylpiperazin-...)
Affinity DataIC50: 4.48E+4nMAssay Description:An AlphaScreen-based high-throughput screening assay can be used to identify inhibitors of the KIF15-TPX2 protein-protein interaction. These inhibito...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
2/23/2025
Entry Details
US Patent

TargetTargeting protein for Xklp2(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50648050(CHEMBL5597299)
Affinity DataKd:  6.30E+4nMAssay Description:Inhibition of 6-His-tagged human Aurora A (126 to 390 residues) expressed in Escherichia coli BL21 (DE3) cells/N-terminal his-tagged/GB-1 fused human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTargeting protein for Xklp2(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50336491(CHEMBL65369 | 3-Hydroxybenzoate, II | 3-hydroxyben...)
Affinity DataKd:  1.00E+6nMAssay Description:Inhibition of 6-His-tagged human Aurora A (126 to 390 residues) expressed in Escherichia coli BL21 (DE3) cells/N-terminal his-tagged/GB-1 fused human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed