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Report error Found 310 of affinity data for UniProtKB/TrEMBL: O00748
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50409669(CHEMBL155514)
Affinity DataIC50: 0.178nMAssay Description:In vitro inhibition of carboxylesterase in human liver microsomes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50409660(CHEMBL155513)
Affinity DataIC50: 3.39nMAssay Description:In vitro inhibition of carboxylesterase in human liver microsomes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50570553(CHEMBL4854298)
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant CES2 expressed in mouse NSO cells using 4-NPA as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50570549(CHEMBL4853742)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of human recombinant CES2 expressed in mouse NSO cells using 4-NPA as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50209402(1,2-bis(2,3-fluorophenyl)ethane-1,2-dione | CHEMBL...)
Affinity DataKi:  4.98nMAssay Description:Inhibition of human intestinal carboxylesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50409672(CHEMBL153080)
Affinity DataIC50: 5.5nMAssay Description:In vitro inhibition of carboxylesterase in human liver microsomes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50643046(CHEMBL5593400)
Affinity DataKi:  5.60nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50350329(CHEMBL1812859)
Affinity DataKi:  5.70nMAssay Description:Inhibition of human intestinal carboxylesterase using o-nitrophenyl acetate as substrate after 5 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50371970(CHEMBL89506)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of human recombinant carboxylesterase 2 after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50371971(CHEMBL440542)
Affinity DataIC50: 6.92nMAssay Description:In vitro inhibition of carboxylesterase in human liver microsomes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50371961(CHEMBL270373)
Affinity DataIC50: 7.40nMAssay Description:Inhibition of human recombinant carboxylesterase 2 after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50371970(CHEMBL89506)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of human recombinant carboxylesterase 2 after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50570554(CHEMBL4858186)
Affinity DataIC50: 9.80nMAssay Description:Inhibition of human recombinant CES2 expressed in mouse NSO cells using 4-NPA as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50643045(CHEMBL5568952)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50643044(CHEMBL5574138)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50643043(CHEMBL5573291)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50371961(CHEMBL270373)
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant carboxylesterase 2 after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50570555(CHEMBL4868014)
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant CES2 expressed in mouse NSO cells using 4-NPA as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50209418(1,2-bis(2,3,4-trifluorophenyl)ethane-1,2-dione | C...)
Affinity DataKi:  13.6nMAssay Description:Inhibition of human intestinal carboxylesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataKi:  14.7nMAssay Description:Inhibition constant against human intestinal carboxylesterase (hiCE) expressed in Sf21 cells using 3 mM o-NPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataKi:  15nMAssay Description:Inhibition of human iCE using o-NPA as substrate by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataKi:  15.1nMAssay Description:Inhibition of human intestinal carboxylesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50570561(CHEMBL4855838)
Affinity DataIC50: 17nMAssay Description:Inhibition of human recombinant CES2 expressed in mouse NSO cells using 4-NPA as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50643040(CHEMBL5569484)
Affinity DataKi:  17nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50643051(CHEMBL5567105)
Affinity DataIC50: 18nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50154561(CHEMBL3774603)
Affinity DataIC50: 20nMAssay Description:Inhibition of CE2 in human liver microsomes using fluorescein diacetate as substrate preincubated for 10 mins followed by substrate addition measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2017
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50371959(CHEMBL86668)
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant carboxylesterase 2 after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50371964(CHEMBL273139)
Affinity DataIC50: 21nMAssay Description:Inhibition of human recombinant carboxylesterase 2 after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50570551(CHEMBL4853637)
Affinity DataIC50: 23nMAssay Description:Inhibition of human recombinant CES2 expressed in mouse NSO cells using 4-NPA as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM22734(CHEMBL193229 | 1,2-bis(3,5-difluorophenyl)ethane-1...)
Affinity DataKi:  23nMAssay Description:Inhibition of human iCE using o-NPA as substrate by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50350329(CHEMBL1812859)
Affinity DataKi:  24.5nMAssay Description:Inhibition of human intestinal carboxylesterase assessed as hydrolysis of CPT-11 after 5 mins by HPLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50350328(CHEMBL1812858)
Affinity DataKi:  25.6nMAssay Description:Inhibition of human intestinal carboxylesterase using o-nitrophenyl acetate as substrate after 5 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50209410(1,2-bis(2,3,4-trifluorophenyl)-2-hydroxyethanone |...)
Affinity DataKi:  25.7nMAssay Description:Inhibition of human intestinal carboxylesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50209414(1,2-bis(3-fluorophenyl)ethane-1,2-dione | CHEMBL24...)
Affinity DataKi:  25.9nMAssay Description:Inhibition of human intestinal carboxylesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50350328(CHEMBL1812858)
Affinity DataKi:  26nMAssay Description:Inhibition of human iCE using o-NPA as substrate by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50371964(CHEMBL273139)
Affinity DataIC50: 26nMAssay Description:Inhibition of human recombinant carboxylesterase 2 after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50350326(CHEMBL1812864)
Affinity DataKi:  28.7nMAssay Description:Inhibition of human intestinal carboxylesterase using o-nitrophenyl acetate as substrate after 5 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM22734(CHEMBL193229 | 1,2-bis(3,5-difluorophenyl)ethane-1...)
Affinity DataKi:  30.6nMAssay Description:Inhibition of human intestinal carboxylesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50209395(1,2-bis(2,3,5-trifluorophenyl)ethane-1,2-dione | C...)
Affinity DataKi:  31.9nMAssay Description:Inhibition of human intestinal carboxylesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM22795(1-[(4-chlorophenyl)methyl]-2,3-dihydro-1H-indole-2...)
Affinity DataKi:  32nMAssay Description:Inhibition of human iCE using o-NPA as substrate by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50409657(CHEMBL153015)
Affinity DataIC50: 32.4nMAssay Description:In vitro inhibition of carboxylesterase in human liver microsomes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50233200(CHEMBL4071772)
Affinity DataKi:  34nMAssay Description:Inhibition of human intestinal CES2 expressed in baculovirus infected sf9 cells using o-nitrophenyl acetate as substrate monitored at 15 secs interva...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50233200(CHEMBL4071772)
Affinity DataKi:  34nMAssay Description:Inhibition of human intestinal CES2 expressed in baculovirus infected sf9 cells using o-nitrophenyl acetate as substrate monitored at 15 secs interva...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50643042(CHEMBL5573951)
Affinity DataKi:  35nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50371959(CHEMBL86668)
Affinity DataIC50: 36nMAssay Description:Inhibition of human recombinant carboxylesterase 2 after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50643046(CHEMBL5593400)
Affinity DataIC50: 38nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM22722(1,2-diphenylethane-1,2-dione | Diphenylethane-1,2-...)
Affinity DataIC50: 38nMAssay Description:Inhibition of human recombinant carboxylesterase 2 after 5 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50009219(2-isopropyl-8,8-dimethyl-5,6,7,8-tetrahydrophenant...)
Affinity DataKi:  40nMAssay Description:Inhibition of human iCE using o-NPA as substrate by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50209416(1,2-bis(2,3,6-trifluorophenyl)ethane-1,2-dione | C...)
Affinity DataKi:  40.7nMAssay Description:Inhibition of human intestinal carboxylesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCocaine esterase(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50154561(CHEMBL3774603)
Affinity DataKi:  42nMAssay Description:Competitive inhibition of CE2 in human liver microsomes using fluorescein diacetate as substrate preincubated for 10 mins followed by substrate addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2017
Entry Details Article
PubMed
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