BDBM60927 1-anilinonaphthalene-8-sulfonic acid::8-Anilino-1-naphthalenesulfonic acid::ANS::Anilinonaphthalene-8-sulfonic acid (ANS)::BDBM50126831
SMILES OS(=O)(=O)c1cccc2cccc(Nc3ccccc3)c12
InChI Key InChIKey=FWEOQOXTVHGIFQ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 29 hits for monomerid = 60927
TargetFatty acid-binding protein, adipocyte(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataKi: 1.00E+3nMAssay Description:Displacement of [3H]-2,3-bis[(2,4-dichlorobenzyl)oxy]benzoic acid from aFABPMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 3.11E+4nM ΔG°: -11.7kcal/moleT: 293.15°CAssay Description:Briefly, steady-state fluorescence spectra of ANS binding was monitored by measuring the increase in fluorescence signal between 450?550 nm following...More data for this Ligand-Target Pair
Affinity DataKi: 2.00E+5nMAssay Description:Inhibition of choline acetyltransferase isolated from squid head gangliaMore data for this Ligand-Target Pair
Affinity DataKd: 1.26E+4nMpH: 8.2 T: 30°CAssay Description:In brief, both wild-type and mutant hFABP5 were expressed and purified to homogeneity as described above and dialyzed in PBS (pH 8.2). Binding affini...More data for this Ligand-Target Pair
Affinity DataKd: 6.10E+3nMpH: 8.2 T: 30°CAssay Description:In brief, both wild-type and mutant hFABP5 were expressed and purified to homogeneity as described above and dialyzed in PBS (pH 8.2). Binding affini...More data for this Ligand-Target Pair
TargetFatty acid-binding protein, adipocyte(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataKd: 150nMAssay Description:Binding affinity to aFABPMore data for this Ligand-Target Pair
Affinity DataKd: 1.10E+3nMAssay Description:Binding affinity to wild type human TTR denominated hormone binding site expressed in Escherichia coli assessed as dissociation constant for first li...More data for this Ligand-Target Pair
Affinity DataKd: 4.80E+3nMAssay Description:Binding affinity to wild type human TTR denominated hormone binding site expressed in Escherichia coli assessed as dissociation constant for second l...More data for this Ligand-Target Pair
Affinity DataKd: 1.80E+3nMAssay Description:Binding affinity to wild type human TTR denominated hormone binding site expressed in Escherichia coli by equilibrium dialysisMore data for this Ligand-Target Pair
Affinity DataKd: 1.00E+4nMAssay Description:Binding affinity to wild type human TTR denominated hormone binding site expressed in Escherichia coli by direct fluorescence titration methodMore data for this Ligand-Target Pair
Affinity DataKd: 1.10E+3nMAssay Description:Binding affinity to wild type human TTR denominated hormone binding site expressed in Escherichia coli assessed as dissociation constant for first li...More data for this Ligand-Target Pair
Affinity DataKd: 4.80E+3nMAssay Description:Binding affinity to wild type human TTR denominated hormone binding site expressed in Escherichia coli assessed as dissociation constant for second l...More data for this Ligand-Target Pair
Affinity DataKd: 4.30E+3nMAssay Description:Binding affinity to wild type human TTR denominated hormone binding site expressed in Escherichia coli by isothermal direct titrimetric assayMore data for this Ligand-Target Pair
Affinity DataKd: 3.70E+4nMAssay Description:Binding affinity to human Cdk2 by fluorescence spectroscopyMore data for this Ligand-Target Pair
Affinity DataIC50: >1.60E+6nMAssay Description:Inhibitory activity against beta-lactamase in the presence of 5 mM KPi concentration of bufferMore data for this Ligand-Target Pair
Affinity DataIC50: >1.60E+6nMAssay Description:Inhibitory activity against beta-lactamaseMore data for this Ligand-Target Pair
Affinity DataIC50: >1.60E+6nMAssay Description:Inhibitory activity against beta-lactamase in the presence of 50 mM KPi concentration of bufferMore data for this Ligand-Target Pair
Affinity DataIC50: >1.60E+6nMAssay Description:Inhibitory activity against beta-lactamase in the presence of 500 mMKPi concentration of bufferMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 12(Human)
Shanghai Jiao-Tong University School of Medicine
Curated by ChEMBL
Shanghai Jiao-Tong University School of Medicine
Curated by ChEMBL
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of p38gamma (unknown origin) using biotinylated maltose peptide as substrate after 60 minsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 13(Human)
Shanghai Jiao-Tong University School of Medicine
Curated by ChEMBL
Shanghai Jiao-Tong University School of Medicine
Curated by ChEMBL
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of p38delta (unknown origin) using biotinylated maltose peptide as substrate after 60 minsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Human)
Shanghai Jiao-Tong University School of Medicine
Curated by ChEMBL
Shanghai Jiao-Tong University School of Medicine
Curated by ChEMBL
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of p38alpha (unknown origin) using biotinylated maltose peptide as substrate after 60 minsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11(Human)
Shanghai Jiao-Tong University School of Medicine
Curated by ChEMBL
Shanghai Jiao-Tong University School of Medicine
Curated by ChEMBL
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of p38beta (unknown origin) using biotinylated maltose peptide as substrate after 60 minsMore data for this Ligand-Target Pair
Affinity DataKd: 3.70E+4nMAssay Description:Binding affinity to CDK2 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 9.10E+4nMAssay Description:Inhibition of CDK2/Cyclin A (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 3.70E+4nMAssay Description:Binding affinity to human CDK2 (1 to 298 residues) expressed in Escherichia coli Tuner(DE3) assessed as dissociation constant by fluorescence spectro...More data for this Ligand-Target Pair
Affinity DataKd: 6.57E+3nMpH: 8.2 T: 30°CAssay Description:In brief, both wild-type and mutant hFABP5 were expressed and purified to homogeneity as described above and dialyzed in PBS (pH 8.2). Binding affini...More data for this Ligand-Target Pair
Affinity DataKd: 70nMAssay Description:The method entails two steps [Lin et al., Biochemistry, 38:185-190]. In the first step, the Kd for association of FABP5 with the fluorescent lipid pr...More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
The First Affiliated Hospital of Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 9.10E+4nMAssay Description:Inhibition of CDK2/cyclinA (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 1.33E+4nMpH: 8.0 T: 37°CAssay Description:ITC experiments were carried out using an iTC200 microcalorimeter (MicroCal) with coin shaped sample cell (200 μL) at 37 C with stirring at 1000...More data for this Ligand-Target Pair
Activity Spreadsheet -- ITC Data from BindingDB
Found 1 hit for monomerid = 60927
ITC DataΔG°: -6.95kcal/mole −TΔS°: -3.27kcal/mole ΔH°: -3.65kcal/mole logk: 7.96E+4
pH: 8.0 T: 37.00°C
pH: 8.0 T: 37.00°C