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Patent code US10071957

Compile Data Set for Download or QSAR
Found 138 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275877
PNG
(US10071957, Example 96)
Show SMILES Fc1cc(COc2cc(Cl)cc(Cl)c2)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1
Show InChI InChI=1S/C20H19Cl2FN2O4S/c21-14-7-15(22)9-16(8-14)29-11-13-6-19(23)18(10-17(13)12-2-3-12)20(26)24-30(27,28)25-4-1-5-25/h6-10,12H,1-5,11H2,(H,24,26)
PDB

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UniProtKB/SwissProt

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n/an/a 0.300n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275876
PNG
(US10071957, Example 95)
Show SMILES Fc1cc(COc2cc(Cl)cc(OC(F)(F)F)c2)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1
Show InChI InChI=1S/C21H19ClF4N2O5S/c22-14-7-15(9-16(8-14)33-21(24,25)26)32-11-13-6-19(23)18(10-17(13)12-2-3-12)20(29)27-34(30,31)28-4-1-5-28/h6-10,12H,1-5,11H2,(H,27,29)
PDB

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n/an/a 2n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275868
PNG
(US10071957, Example 87)
Show SMILES CC(C)Oc1ncc(Oc2cc(F)c(cc2C2CC2)C(=O)NS(=O)(=O)N2CCC2)cc1Cl
Show InChI InChI=1S/C21H23ClFN3O5S/c1-12(2)30-21-17(22)8-14(11-24-21)31-19-10-18(23)16(9-15(19)13-4-5-13)20(27)25-32(28,29)26-6-3-7-26/h8-13H,3-7H2,1-2H3,(H,25,27)
PDB

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n/an/a 2.10n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275873
PNG
(US10071957, Example 92)
Show SMILES Fc1cc(Oc2cnc(OCC(F)(F)F)c(Cl)c2)c(C=C)cc1C(=O)NS(=O)(=O)N1CCC1
Show InChI InChI=1S/C19H16ClF4N3O5S/c1-2-11-6-13(17(28)26-33(29,30)27-4-3-5-27)15(21)8-16(11)32-12-7-14(20)18(25-9-12)31-10-19(22,23)24/h2,6-9H,1,3-5,10H2,(H,26,28)
PDB

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n/an/a 4.30n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275872
PNG
(US10071957, Example 91)
Show SMILES CC(C)Oc1ncc(Oc2cc(F)c(cc2C=C)C(=O)NS(=O)(=O)N2CCC2)cc1Cl
Show InChI InChI=1S/C20H21ClFN3O5S/c1-4-13-8-15(19(26)24-31(27,28)25-6-5-7-25)17(22)10-18(13)30-14-9-16(21)20(23-11-14)29-12(2)3/h4,8-12H,1,5-7H2,2-3H3,(H,24,26)
PDB

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n/an/a 5n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275871
PNG
(US10071957, Example 90)
Show SMILES CNS(=O)(=O)NC(=O)c1cc(C2CC2)c(Oc2cnc(OC(C)C)c(Cl)c2)cc1F
Show InChI InChI=1S/C19H21ClFN3O5S/c1-10(2)28-19-15(20)6-12(9-23-19)29-17-8-16(21)14(7-13(17)11-4-5-11)18(25)24-30(26,27)22-3/h6-11,22H,4-5H2,1-3H3,(H,24,25)
PDB

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n/an/a 6n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275868
PNG
(US10071957, Example 87)
Show SMILES CC(C)Oc1ncc(Oc2cc(F)c(cc2C2CC2)C(=O)NS(=O)(=O)N2CCC2)cc1Cl
Show InChI InChI=1S/C21H23ClFN3O5S/c1-12(2)30-21-17(22)8-14(11-24-21)31-19-10-18(23)16(9-15(19)13-4-5-13)20(27)25-32(28,29)26-6-3-7-26/h8-13H,3-7H2,1-2H3,(H,25,27)
PDB

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n/an/a 6n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50118513
PNG
(CHEMBL3617065 | US10071957, Example 6)
Show SMILES CNS(=O)(=O)NC(=O)c1cc(Cl)c(Oc2cnc(OCC(C)C)c(Cl)c2)cc1F
Show InChI InChI=1S/C17H18Cl2FN3O5S/c1-9(2)8-27-17-13(19)4-10(7-22-17)28-15-6-14(20)11(5-12(15)18)16(24)23-29(25,26)21-3/h4-7,9,21H,8H2,1-3H3,(H,23,24)
PDB

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PC cid
PC sid
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n/an/a 6n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275863
PNG
(US10071957, Example 82)
Show SMILES CC(C)Oc1ncc(OCc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)N2CCC2)cc1Cl
Show InChI InChI=1S/C19H20Cl2FN3O5S/c1-11(2)30-19-16(21)7-13(9-23-19)29-10-12-6-17(22)14(8-15(12)20)18(26)24-31(27,28)25-4-3-5-25/h6-9,11H,3-5,10H2,1-2H3,(H,24,26)
PDB

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n/an/a 6.10n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275872
PNG
(US10071957, Example 91)
Show SMILES CC(C)Oc1ncc(Oc2cc(F)c(cc2C=C)C(=O)NS(=O)(=O)N2CCC2)cc1Cl
Show InChI InChI=1S/C20H21ClFN3O5S/c1-4-13-8-15(19(26)24-31(27,28)25-6-5-7-25)17(22)10-18(13)30-14-9-16(21)20(23-11-14)29-12(2)3/h4,8-12H,1,5-7H2,2-3H3,(H,24,26)
PDB

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n/an/a 6.70n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275865
PNG
(US10071957, Example 84)
Show SMILES CC(C)Oc1ncc(Oc2ccc(cc2C2CC2)C(=O)NS(=O)(=O)N2CCC2)cc1Cl
Show InChI InChI=1S/C21H24ClN3O5S/c1-13(2)29-21-18(22)11-16(12-23-21)30-19-7-6-15(10-17(19)14-4-5-14)20(26)24-31(27,28)25-8-3-9-25/h6-7,10-14H,3-5,8-9H2,1-2H3,(H,24,26)
PDB

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UniProtKB/SwissProt

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n/an/a 8.40n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM50118513
PNG
(CHEMBL3617065 | US10071957, Example 6)
Show SMILES CNS(=O)(=O)NC(=O)c1cc(Cl)c(Oc2cnc(OCC(C)C)c(Cl)c2)cc1F
Show InChI InChI=1S/C17H18Cl2FN3O5S/c1-9(2)8-27-17-13(19)4-10(7-22-17)28-15-6-14(20)11(5-12(15)18)16(24)23-29(25,26)21-3/h4-7,9,21H,8H2,1-3H3,(H,23,24)
PDB

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PC sid
UniChem

Similars

n/an/a 8.5n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275879
PNG
(US10071957, Example 98)
Show SMILES Fc1cc(COc2ccc(Cl)c(Cl)c2)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1
Show InChI InChI=1S/C20H19Cl2FN2O4S/c21-17-5-4-14(9-18(17)22)29-11-13-8-19(23)16(10-15(13)12-2-3-12)20(26)24-30(27,28)25-6-1-7-25/h4-5,8-10,12H,1-3,6-7,11H2,(H,24,26)
PDB

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n/an/a 9n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275875
PNG
(US10071957, Example 94)
Show SMILES Fc1cc(Oc2cnc(OCC(F)(F)F)c(Cl)c2)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1
Show InChI InChI=1S/C20H18ClF4N3O5S/c21-15-6-12(9-26-19(15)32-10-20(23,24)25)33-17-8-16(22)14(7-13(17)11-2-3-11)18(29)27-34(30,31)28-4-1-5-28/h6-9,11H,1-5,10H2,(H,27,29)
PDB

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n/an/a 9n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275787
PNG
(5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...)
Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(N)(=O)=O)cc1Cl
Show InChI InChI=1S/C16H16Cl2FN3O5S/c1-8(2)7-26-16-12(18)3-9(6-21-16)27-14-5-13(19)10(4-11(14)17)15(23)22-28(20,24)25/h3-6,8H,7H2,1-2H3,(H,22,23)(H2,20,24,25)
PDB

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n/an/a 9n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275809
PNG
(N-((1H-imidazol-4- yl)sulfonyl)-5-chloro- 4-((5-ch...)
Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)c2c[nH]cn2)cc1Cl
PDB

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n/an/a 9n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275828
PNG
(N-(azetidin-1- ylsulfonyl)-5-chloro- 4-((5-chloro-...)
Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)N2CCC2)cc1Cl
Show InChI InChI=1S/C19H20Cl2FN3O5S/c1-11(2)10-29-19-15(21)6-12(9-23-19)30-17-8-16(22)13(7-14(17)20)18(26)24-31(27,28)25-4-3-5-25/h6-9,11H,3-5,10H2,1-2H3,(H,24,26)
PDB

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n/an/a 9.20n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275784
PNG
(5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...)
Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)N(C)C)cc1Cl
Show InChI InChI=1S/C18H20Cl2FN3O5S/c1-10(2)9-28-18-14(20)5-11(8-22-18)29-16-7-15(21)12(6-13(16)19)17(25)23-30(26,27)24(3)4/h5-8,10H,9H2,1-4H3,(H,23,25)
PDB

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n/an/a 11n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275873
PNG
(US10071957, Example 92)
Show SMILES Fc1cc(Oc2cnc(OCC(F)(F)F)c(Cl)c2)c(C=C)cc1C(=O)NS(=O)(=O)N1CCC1
Show InChI InChI=1S/C19H16ClF4N3O5S/c1-2-11-6-13(17(28)26-33(29,30)27-4-3-5-27)15(21)8-16(11)32-12-7-14(20)18(25-9-12)31-10-19(22,23)24/h2,6-9H,1,3-5,10H2,(H,26,28)
PDB

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n/an/a 11n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275867
PNG
(US10071957, Example 86)
Show SMILES COc1ncccc1-c1cc(ccc1Oc1cnc(OC(C)C)c(Cl)c1)C(=O)NS(=O)(=O)N1CCC1
Show InChI InChI=1S/C24H25ClN4O6S/c1-15(2)34-24-20(25)13-17(14-27-24)35-21-8-7-16(22(30)28-36(31,32)29-10-5-11-29)12-19(21)18-6-4-9-26-23(18)33-3/h4,6-9,12-15H,5,10-11H2,1-3H3,(H,28,30)
PDB

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UniChem
n/an/a 11n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275861
PNG
(US10071957, Example 80)
Show SMILES CNS(=O)(=O)NC(=O)c1cc(Cl)c(COc2ccc(Cl)c(Cl)c2)cc1F
Show InChI InChI=1S/C15H12Cl3FN2O4S/c1-20-26(23,24)21-15(22)10-6-12(17)8(4-14(10)19)7-25-9-2-3-11(16)13(18)5-9/h2-6,20H,7H2,1H3,(H,21,22)
PDB

KEGG

UniProtKB/SwissProt

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DrugBank
GoogleScholar
AffyNet 
UniChem
n/an/a 11.6n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275794
PNG
(5-chloro-4-(3-chloro- 4-(trifluoromethoxy) phenoxy...)
Show SMILES CNS(=O)(=O)NC(=O)c1cc(Cl)c(Oc2ccc(OC(F)(F)F)c(Cl)c2)cc1F
Show InChI InChI=1S/C15H10Cl2F4N2O5S/c1-22-29(25,26)23-14(24)8-5-10(17)13(6-11(8)18)27-7-2-3-12(9(16)4-7)28-15(19,20)21/h2-6,22H,1H3,(H,23,24)
PDB

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UniProtKB/SwissProt

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DrugBank
GoogleScholar
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UniChem
n/an/a 15n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275792
PNG
(N-(azetidin-1- ylsulfonyl)-5-chloro- 4-(4-chloro-3...)
Show SMILES Fc1cc(Oc2ccc(Cl)c(c2)C(F)(F)F)c(Cl)cc1C(=O)NS(=O)(=O)N1CCC1
Show InChI InChI=1S/C17H12Cl2F4N2O4S/c18-12-3-2-9(6-11(12)17(21,22)23)29-15-8-14(20)10(7-13(15)19)16(26)24-30(27,28)25-4-1-5-25/h2-3,6-8H,1,4-5H2,(H,24,26)
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n/an/a 16n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275874
PNG
(US10071957, Example 93)
Show SMILES Fc1cc(Oc2cnc(OCC(F)(F)F)c(Cl)c2)c(Cl)cc1C(=O)NS(=O)(=O)N1CCC1
Show InChI InChI=1S/C17H13Cl2F4N3O5S/c18-11-5-10(15(27)25-32(28,29)26-2-1-3-26)13(20)6-14(11)31-9-4-12(19)16(24-7-9)30-8-17(21,22)23/h4-7H,1-3,8H2,(H,25,27)
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n/an/a 16n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275860
PNG
(US10071957, Example 79)
Show SMILES Fc1cc(COc2ccc(OC(F)(F)F)c(Cl)c2)c(Cl)cc1C(=O)NS(=O)(=O)N1CCC1
Show InChI InChI=1S/C18H14Cl2F4N2O5S/c19-13-8-12(17(27)25-32(28,29)26-4-1-5-26)15(21)6-10(13)9-30-11-2-3-16(14(20)7-11)31-18(22,23)24/h2-3,6-8H,1,4-5,9H2,(H,25,27)
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n/an/a 17n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275788
PNG
(5-chloro-4-((3,4- dichlorophenoxy) methyl)-N-(N,N-...)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(COc2ccc(Cl)c(Cl)c2)cc1F
Show InChI InChI=1S/C16H14Cl3FN2O4S/c1-22(2)27(24,25)21-16(23)11-7-13(18)9(5-15(11)20)8-26-10-3-4-12(17)14(19)6-10/h3-7H,8H2,1-2H3,(H,21,23)
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n/an/a 19n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275791
PNG
(5-chloro-4-(4-chloro- 3-(trifluoromethyl) phenoxy)...)
Show SMILES CNS(=O)(=O)NC(=O)c1cc(Cl)c(Oc2ccc(Cl)c(c2)C(F)(F)F)cc1F
Show InChI InChI=1S/C15H10Cl2F4N2O4S/c1-22-28(25,26)23-14(24)8-5-11(17)13(6-12(8)18)27-7-2-3-10(16)9(4-7)15(19,20)21/h2-6,22H,1H3,(H,23,24)
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n/an/a 22n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275867
PNG
(US10071957, Example 86)
Show SMILES COc1ncccc1-c1cc(ccc1Oc1cnc(OC(C)C)c(Cl)c1)C(=O)NS(=O)(=O)N1CCC1
Show InChI InChI=1S/C24H25ClN4O6S/c1-15(2)34-24-20(25)13-17(14-27-24)35-21-8-7-16(22(30)28-36(31,32)29-10-5-11-29)12-19(21)18-6-4-9-26-23(18)33-3/h4,6-9,12-15H,5,10-11H2,1-3H3,(H,28,30)
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n/an/a 22n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275815
PNG
(5-chloro-4-((5-chloro- 6-(2,2,3,3-tetrafluoro- pro...)
Show SMILES CNS(=O)(=O)NC(=O)c1cc(Cl)c(Oc2cnc(OCC(F)(F)C(F)F)c(Cl)c2)cc1F
Show InChI InChI=1S/C16H12Cl2F5N3O5S/c1-24-32(28,29)26-13(27)8-3-9(17)12(4-11(8)19)31-7-2-10(18)14(25-5-7)30-6-16(22,23)15(20)21/h2-5,15,24H,6H2,1H3,(H,26,27)
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n/an/a 22.8n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275784
PNG
(5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...)
Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)N(C)C)cc1Cl
Show InChI InChI=1S/C18H20Cl2FN3O5S/c1-10(2)9-28-18-14(20)5-11(8-22-18)29-16-7-15(21)12(6-13(16)19)17(25)23-30(26,27)24(3)4/h5-8,10H,9H2,1-4H3,(H,23,25)
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n/an/a 24.8n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275865
PNG
(US10071957, Example 84)
Show SMILES CC(C)Oc1ncc(Oc2ccc(cc2C2CC2)C(=O)NS(=O)(=O)N2CCC2)cc1Cl
Show InChI InChI=1S/C21H24ClN3O5S/c1-13(2)29-21-18(22)11-16(12-23-21)30-19-7-6-15(10-17(19)14-4-5-14)20(26)24-31(27,28)25-8-3-9-25/h6-7,10-14H,3-5,8-9H2,1-2H3,(H,24,26)
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n/an/a 25n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275847
PNG
(5-chloro-4-((5-chloro- 6-(2,2,3,3-tetrafluoro- pro...)
Show SMILES FC(F)C(F)(F)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)N2CCCC2)cc1Cl
Show InChI InChI=1S/C19H16Cl2F5N3O5S/c20-12-6-11(16(30)28-35(31,32)29-3-1-2-4-29)14(22)7-15(12)34-10-5-13(21)17(27-8-10)33-9-19(25,26)18(23)24/h5-8,18H,1-4,9H2,(H,28,30)
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n/an/a 26n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275866
PNG
(US10071957, Example 85)
Show SMILES Fc1cc(COc2ccc(Cl)c(c2)C(F)(F)F)c(Cl)cc1C(=O)NS(=O)(=O)N1CCC1
Show InChI InChI=1S/C18H14Cl2F4N2O4S/c19-14-3-2-11(7-13(14)18(22,23)24)30-9-10-6-16(21)12(8-15(10)20)17(27)25-31(28,29)26-4-1-5-26/h2-3,6-8H,1,4-5,9H2,(H,25,27)
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n/an/a 26n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275861
PNG
(US10071957, Example 80)
Show SMILES CNS(=O)(=O)NC(=O)c1cc(Cl)c(COc2ccc(Cl)c(Cl)c2)cc1F
Show InChI InChI=1S/C15H12Cl3FN2O4S/c1-20-26(23,24)21-15(22)10-6-12(17)8(4-14(10)19)7-25-9-2-3-11(16)13(18)5-9/h2-6,20H,7H2,1H3,(H,21,22)
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n/an/a 28n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275797
PNG
(5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...)
Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)N2CCCC2)cc1Cl
Show InChI InChI=1S/C20H22Cl2FN3O5S/c1-12(2)11-30-20-16(22)7-13(10-24-20)31-18-9-17(23)14(8-15(18)21)19(27)25-32(28,29)26-5-3-4-6-26/h7-10,12H,3-6,11H2,1-2H3,(H,25,27)
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n/an/a 30.1n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275807
PNG
(5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...)
Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)c2cn(C)cn2)cc1Cl
Show InChI InChI=1S/C20H19Cl2FN4O5S/c1-11(2)9-31-20-15(22)4-12(7-24-20)32-17-6-16(23)13(5-14(17)21)19(28)26-33(29,30)18-8-27(3)10-25-18/h4-8,10-11H,9H2,1-3H3,(H,26,28)
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n/an/a 34n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275813
PNG
(5-chloro-4-(5-chloro- 6-(2,2,3,3-tetrafluoro- prop...)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(Oc2cnc(OCC(F)(F)C(F)F)c(Cl)c2)cc1F
Show InChI InChI=1S/C17H14Cl2F5N3O5S/c1-27(2)33(29,30)26-14(28)9-4-10(18)13(5-12(9)20)32-8-3-11(19)15(25-6-8)31-7-17(23,24)16(21)22/h3-6,16H,7H2,1-2H3,(H,26,28)
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n/an/a 34n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275821
PNG
(5-chloro-4-(((5-chloro- 6-(2,2,3,3-tetrafluoro- pr...)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(COc2cnc(OCC(F)(F)C(F)F)c(Cl)c2)cc1F
Show InChI InChI=1S/C18H16Cl2F5N3O5S/c1-28(2)34(30,31)27-15(29)11-5-12(19)9(3-14(11)21)7-32-10-4-13(20)16(26-6-10)33-8-18(24,25)17(22)23/h3-6,17H,7-8H2,1-2H3,(H,27,29)
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n/an/a 34.3n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275859
PNG
(US10071957, Example 78)
Show SMILES CNS(=O)(=O)NC(=O)c1cc(Cl)c(COc2ccc(Cl)c(c2)C(F)(F)F)cc1F
Show InChI InChI=1S/C16H12Cl2F4N2O4S/c1-23-29(26,27)24-15(25)10-6-13(18)8(4-14(10)19)7-28-9-2-3-12(17)11(5-9)16(20,21)22/h2-6,23H,7H2,1H3,(H,24,25)
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n/an/a 35n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275795
PNG
(5-chloro-4-(3-chloro- 4-(trifluoromethoxy) phenoxy...)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(Oc2ccc(OC(F)(F)F)c(Cl)c2)cc1F
Show InChI InChI=1S/C16H12Cl2F4N2O5S/c1-24(2)30(26,27)23-15(25)9-6-11(18)14(7-12(9)19)28-8-3-4-13(10(17)5-8)29-16(20,21)22/h3-7H,1-2H3,(H,23,25)
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n/an/a 41n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275864
PNG
(US10071957, Example 83)
Show SMILES CNS(=O)(=O)NC(=O)c1ccc(Oc2cnc(OC(C)C)c(Cl)c2)c(c1)-c1cccnc1OC
Show InChI InChI=1S/C22H23ClN4O6S/c1-13(2)32-22-18(23)11-15(12-26-22)33-19-8-7-14(20(28)27-34(29,30)24-3)10-17(19)16-6-5-9-25-21(16)31-4/h5-13,24H,1-4H3,(H,27,28)
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n/an/a 43n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275881
PNG
(US10071957, Example 100)
Show SMILES CNS(=O)(=O)NC(=O)c1cc(Cl)c(COc2ccc(OC(F)(F)F)c(Cl)c2)cc1F
Show InChI InChI=1S/C16H12Cl2F4N2O5S/c1-23-30(26,27)24-15(25)10-6-11(17)8(4-13(10)19)7-28-9-2-3-14(12(18)5-9)29-16(20,21)22/h2-6,23H,7H2,1H3,(H,24,25)
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n/an/a 43n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275863
PNG
(US10071957, Example 82)
Show SMILES CC(C)Oc1ncc(OCc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)N2CCC2)cc1Cl
Show InChI InChI=1S/C19H20Cl2FN3O5S/c1-11(2)30-19-16(21)7-13(9-23-19)29-10-12-6-17(22)14(8-15(12)20)18(26)24-31(27,28)25-4-3-5-25/h6-9,11H,3-5,10H2,1-2H3,(H,24,26)
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n/an/a 43n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275869
PNG
(US10071957, Example 88)
Show SMILES CC(C)Oc1ncc(Oc2cc(F)c(cc2C2(F)COC2)C(=O)NS(=O)(=O)N2CCC2)cc1Cl
Show InChI InChI=1S/C21H22ClF2N3O6S/c1-12(2)32-20-16(22)6-13(9-25-20)33-18-8-17(23)14(7-15(18)21(24)10-31-11-21)19(28)26-34(29,30)27-4-3-5-27/h6-9,12H,3-5,10-11H2,1-2H3,(H,26,28)
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n/an/a 44n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275797
PNG
(5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...)
Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)N2CCCC2)cc1Cl
Show InChI InChI=1S/C20H22Cl2FN3O5S/c1-12(2)11-30-20-16(22)7-13(10-24-20)31-18-9-17(23)14(8-15(18)21)19(27)25-32(28,29)26-5-3-4-6-26/h7-10,12H,3-6,11H2,1-2H3,(H,25,27)
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n/an/a 44n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275813
PNG
(5-chloro-4-(5-chloro- 6-(2,2,3,3-tetrafluoro- prop...)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(Oc2cnc(OCC(F)(F)C(F)F)c(Cl)c2)cc1F
Show InChI InChI=1S/C17H14Cl2F5N3O5S/c1-27(2)33(29,30)26-14(28)9-4-10(18)13(5-12(9)20)32-8-3-11(19)15(25-6-8)31-7-17(23,24)16(21)22/h3-6,16H,7H2,1-2H3,(H,26,28)
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n/an/a 47.8n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275880
PNG
(US10071957, Example 99)
Show SMILES Fc1cc(COc2ccc(Cl)c(Cl)c2)c(Cl)cc1C(=O)NS(=O)(=O)N1CCC1
Show InChI InChI=1S/C17H14Cl3FN2O4S/c18-13-3-2-11(7-15(13)20)27-9-10-6-16(21)12(8-14(10)19)17(24)22-28(25,26)23-4-1-5-23/h2-3,6-8H,1,4-5,9H2,(H,22,24)
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n/an/a 51n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275878
PNG
(US10071957, Example 97)
Show SMILES COc1ncccc1-c1cc(ccc1Oc1ccc(OC(F)(F)F)c(Cl)c1)C(=O)NS(=O)(=O)N1CCC1
Show InChI InChI=1S/C23H19ClF3N3O6S/c1-34-22-16(4-2-9-28-22)17-12-14(21(31)29-37(32,33)30-10-3-11-30)5-7-19(17)35-15-6-8-20(18(24)13-15)36-23(25,26)27/h2,4-9,12-13H,3,10-11H2,1H3,(H,29,31)
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n/an/a 52n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275770
PNG
(5-chloro-4-(4-chloro- 3-(trifluoromethyl) phenoxy)...)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(Oc2ccc(Cl)c(c2)C(F)(F)F)cc1F
Show InChI InChI=1S/C16H12Cl2F4N2O4S/c1-24(2)29(26,27)23-15(25)9-6-12(18)14(7-13(9)19)28-8-3-4-11(17)10(5-8)16(20,21)22/h3-7H,1-2H3,(H,23,25)
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n/an/a 53n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275811
PNG
(5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...)
Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)c2cccnc2)cc1Cl
Show InChI InChI=1S/C21H18Cl2FN3O5S/c1-12(2)11-31-21-17(23)6-13(9-26-21)32-19-8-18(24)15(7-16(19)22)20(28)27-33(29,30)14-4-3-5-25-10-14/h3-10,12H,11H2,1-2H3,(H,27,28)
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n/an/a 57n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275798
PNG
(5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...)
Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)N2CCCCC2)cc1Cl
Show InChI InChI=1S/C21H24Cl2FN3O5S/c1-13(2)12-31-21-17(23)8-14(11-25-21)32-19-10-18(24)15(9-16(19)22)20(28)26-33(29,30)27-6-4-3-5-7-27/h8-11,13H,3-7,12H2,1-2H3,(H,26,28)
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n/an/a 58.4n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275798
PNG
(5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...)
Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)N2CCCCC2)cc1Cl
Show InChI InChI=1S/C21H24Cl2FN3O5S/c1-13(2)12-31-21-17(23)8-14(11-25-21)32-19-10-18(24)15(9-16(19)22)20(28)26-33(29,30)27-6-4-3-5-7-27/h8-11,13H,3-7,12H2,1-2H3,(H,26,28)
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n/an/a 64n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275882
PNG
(US10071957, Example 101)
Show SMILES FC(F)C(F)(F)COc1ncc(OCc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)N2CCC2)cc1Cl
Show InChI InChI=1S/C19H16Cl2F5N3O5S/c20-13-6-12(16(30)28-35(31,32)29-2-1-3-29)15(22)4-10(13)8-33-11-5-14(21)17(27-7-11)34-9-19(25,26)18(23)24/h4-7,18H,1-3,8-9H2,(H,28,30)
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n/an/a 68n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275787
PNG
(5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...)
Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(N)(=O)=O)cc1Cl
Show InChI InChI=1S/C16H16Cl2FN3O5S/c1-8(2)7-26-16-12(18)3-9(6-21-16)27-14-5-13(19)10(4-11(14)17)15(23)22-28(20,24)25/h3-6,8H,7H2,1-2H3,(H,22,23)(H2,20,24,25)
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n/an/a 70.8n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275822
PNG
(5-chloro-N-(N,N- dimethylsulfamoyl)-2- fluoro-4-((...)
Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)N(C)C)cc1C(F)(F)F
Show InChI InChI=1S/C19H20ClF4N3O5S/c1-10(2)9-31-18-13(19(22,23)24)5-11(8-25-18)32-16-7-15(21)12(6-14(16)20)17(28)26-33(29,30)27(3)4/h5-8,10H,9H2,1-4H3,(H,26,28)
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n/an/a 71n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275799
PNG
(N-(azepan-1- ylsulfonyl)-5-chloro- 4-((5-chloro-6-...)
Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)N2CCCCCC2)cc1Cl
Show InChI InChI=1S/C22H26Cl2FN3O5S/c1-14(2)13-32-22-18(24)9-15(12-26-22)33-20-11-19(25)16(10-17(20)23)21(29)27-34(30,31)28-7-5-3-4-6-8-28/h9-12,14H,3-8,13H2,1-2H3,(H,27,29)
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n/an/a 73n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275849
PNG
(5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...)
Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)N2CCOCC2)cc1Cl
Show InChI InChI=1S/C20H22Cl2FN3O6S/c1-12(2)11-31-20-16(22)7-13(10-24-20)32-18-9-17(23)14(8-15(18)21)19(27)25-33(28,29)26-3-5-30-6-4-26/h7-10,12H,3-6,11H2,1-2H3,(H,25,27)
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n/an/a 77n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275809
PNG
(N-((1H-imidazol-4- yl)sulfonyl)-5-chloro- 4-((5-ch...)
Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)c2c[nH]cn2)cc1Cl
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n/an/a 77.3n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275792
PNG
(N-(azetidin-1- ylsulfonyl)-5-chloro- 4-(4-chloro-3...)
Show SMILES Fc1cc(Oc2ccc(Cl)c(c2)C(F)(F)F)c(Cl)cc1C(=O)NS(=O)(=O)N1CCC1
Show InChI InChI=1S/C17H12Cl2F4N2O4S/c18-12-3-2-9(6-11(12)17(21,22)23)29-15-8-14(20)10(7-13(15)19)16(26)24-30(27,28)25-4-1-5-25/h2-3,6-8H,1,4-5H2,(H,24,26)
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n/an/a 80.7n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275846
PNG
(4-((5-chloro-6-iso- butoxypyridin-3-yl) oxy)-5-cya...)
Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2C#N)C(=O)NS(=O)(=O)N(C)C)cc1Cl
Show InChI InChI=1S/C19H20ClFN4O5S/c1-11(2)10-29-19-15(20)6-13(9-23-19)30-17-7-16(21)14(5-12(17)8-22)18(26)24-31(27,28)25(3)4/h5-7,9,11H,10H2,1-4H3,(H,24,26)
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n/an/a 93n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275848
PNG
(5-chloro-4-((5-chloro- 6-(2,2,3,3-tetrafluoro- pro...)
Show SMILES FC(F)C(F)(F)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)N2CCOCC2)cc1Cl
Show InChI InChI=1S/C19H16Cl2F5N3O6S/c20-12-6-11(16(30)28-36(31,32)29-1-3-33-4-2-29)14(22)7-15(12)35-10-5-13(21)17(27-8-10)34-9-19(25,26)18(23)24/h5-8,18H,1-4,9H2,(H,28,30)
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n/an/a 98n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275827
PNG
(5-chloro-4-(3-chloro- 4-(trifluoromethoxy) phenoxy...)
Show SMILES Fc1cc(Oc2ccc(OC(F)(F)F)c(Cl)c2)c(Cl)cc1C(=O)NS(=O)(=O)NC1CCC1
Show InChI InChI=1S/C18H14Cl2F4N2O5S/c19-12-6-10(4-5-15(12)31-18(22,23)24)30-16-8-14(21)11(7-13(16)20)17(27)26-32(28,29)25-9-2-1-3-9/h4-9,25H,1-3H2,(H,26,27)
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n/an/a 108n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275791
PNG
(5-chloro-4-(4-chloro- 3-(trifluoromethyl) phenoxy)...)
Show SMILES CNS(=O)(=O)NC(=O)c1cc(Cl)c(Oc2ccc(Cl)c(c2)C(F)(F)F)cc1F
Show InChI InChI=1S/C15H10Cl2F4N2O4S/c1-22-28(25,26)23-14(24)8-5-11(17)13(6-12(8)18)27-7-2-3-10(16)9(4-7)15(19,20)21/h2-6,22H,1H3,(H,23,24)
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n/an/a 109n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275800
PNG
(5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...)
Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)N(C)C(C)C)cc1Cl
Show InChI InChI=1S/C20H24Cl2FN3O5S/c1-11(2)10-30-20-16(22)6-13(9-24-20)31-18-8-17(23)14(7-15(18)21)19(27)25-32(28,29)26(5)12(3)4/h6-9,11-12H,10H2,1-5H3,(H,25,27)
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n/an/a 123n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275800
PNG
(5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...)
Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)N(C)C(C)C)cc1Cl
Show InChI InChI=1S/C20H24Cl2FN3O5S/c1-11(2)10-30-20-16(22)6-13(9-24-20)31-18-8-17(23)14(7-15(18)21)19(27)25-32(28,29)26(5)12(3)4/h6-9,11-12H,10H2,1-5H3,(H,25,27)
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n/an/a 125n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275830
PNG
(5-chloro-2-fluoro-4- (naphthalen-2-yloxy)- N-sulfa...)
Show SMILES NS(=O)(=O)NC(=O)c1cc(Cl)c(Oc2ccc3ccccc3c2)cc1F
Show InChI InChI=1S/C17H12ClFN2O4S/c18-14-8-13(17(22)21-26(20,23)24)15(19)9-16(14)25-12-6-5-10-3-1-2-4-11(10)7-12/h1-9H,(H,21,22)(H2,20,23,24)
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n/an/a 138n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275858
PNG
(US10071957, Example 77)
Show SMILES CNS(=O)(=O)NC(=O)c1cc(Cl)c(COc2cnc(OC(C)C)c(Cl)c2)cc1F
Show InChI InChI=1S/C17H18Cl2FN3O5S/c1-9(2)28-17-14(19)5-11(7-22-17)27-8-10-4-15(20)12(6-13(10)18)16(24)23-29(25,26)21-3/h4-7,9,21H,8H2,1-3H3,(H,23,24)
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n/an/a 140n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275844
PNG
(5-chloro-4-((5-chloro- 6-(piperidin-1-yl) pyridin-...)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(Oc2cnc(N3CCCCC3)c(Cl)c2)cc1F
Show InChI InChI=1S/C19H21Cl2FN4O4S/c1-25(2)31(28,29)24-19(27)13-9-14(20)17(10-16(13)22)30-12-8-15(21)18(23-11-12)26-6-4-3-5-7-26/h8-11H,3-7H2,1-2H3,(H,24,27)
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n/an/a 140n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275782
PNG
(4-((3,4-dichloro- phenoxy)methyl)-N- (N,N-dimethyl...)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1ccc(COc2ccc(Cl)c(Cl)c2)cc1
Show InChI InChI=1S/C16H16Cl2N2O4S/c1-20(2)25(22,23)19-16(21)12-5-3-11(4-6-12)10-24-13-7-8-14(17)15(18)9-13/h3-9H,10H2,1-2H3,(H,19,21)
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n/an/a 142n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275794
PNG
(5-chloro-4-(3-chloro- 4-(trifluoromethoxy) phenoxy...)
Show SMILES CNS(=O)(=O)NC(=O)c1cc(Cl)c(Oc2ccc(OC(F)(F)F)c(Cl)c2)cc1F
Show InChI InChI=1S/C15H10Cl2F4N2O5S/c1-22-29(25,26)23-14(24)8-5-10(17)13(6-11(8)18)27-7-2-3-12(9(16)4-7)28-15(19,20)21/h2-6,22H,1H3,(H,23,24)
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n/an/a 145n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275819
PNG
(5-chloro-4-((5-chloro- 6-(2,2,3,3-tetrafluoro- pro...)
Show SMILES NS(=O)(=O)NC(=O)c1cc(Cl)c(Oc2cnc(OCC(F)(F)C(F)F)c(Cl)c2)cc1F
Show InChI InChI=1S/C15H10Cl2F5N3O5S/c16-8-2-7(12(26)25-31(23,27)28)10(18)3-11(8)30-6-1-9(17)13(24-4-6)29-5-15(21,22)14(19)20/h1-4,14H,5H2,(H,25,26)(H2,23,27,28)
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n/an/a 171n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275788
PNG
(5-chloro-4-((3,4- dichlorophenoxy) methyl)-N-(N,N-...)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(COc2ccc(Cl)c(Cl)c2)cc1F
Show InChI InChI=1S/C16H14Cl3FN2O4S/c1-22(2)27(24,25)21-16(23)11-7-13(18)9(5-15(11)20)8-26-10-3-4-12(17)14(19)6-10/h3-7H,8H2,1-2H3,(H,21,23)
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n/an/a 174n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275790
PNG
(5-chloro-4-(4-chloro- 3-(trifluoromethyl) phenoxy)...)
Show SMILES NS(=O)(=O)NC(=O)c1cc(Cl)c(Oc2ccc(Cl)c(c2)C(F)(F)F)cc1F
Show InChI InChI=1S/C14H8Cl2F4N2O4S/c15-9-2-1-6(3-8(9)14(18,19)20)26-12-5-11(17)7(4-10(12)16)13(23)22-27(21,24)25/h1-5H,(H,22,23)(H2,21,24,25)
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n/an/a 190n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275808
PNG
(5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...)
Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)N2CCc3ccccc23)cc1Cl
Show InChI InChI=1S/C24H22Cl2FN3O5S/c1-14(2)13-34-24-19(26)9-16(12-28-24)35-22-11-20(27)17(10-18(22)25)23(31)29-36(32,33)30-8-7-15-5-3-4-6-21(15)30/h3-6,9-12,14H,7-8,13H2,1-2H3,(H,29,31)
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n/an/a 190n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275821
PNG
(5-chloro-4-(((5-chloro- 6-(2,2,3,3-tetrafluoro- pr...)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(COc2cnc(OCC(F)(F)C(F)F)c(Cl)c2)cc1F
Show InChI InChI=1S/C18H16Cl2F5N3O5S/c1-28(2)34(30,31)27-15(29)11-5-12(19)9(3-14(11)21)7-32-10-4-13(20)16(26-6-10)33-8-18(24,25)17(22)23/h3-6,17H,7-8H2,1-2H3,(H,27,29)
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n/an/a 216n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275795
PNG
(5-chloro-4-(3-chloro- 4-(trifluoromethoxy) phenoxy...)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(Oc2ccc(OC(F)(F)F)c(Cl)c2)cc1F
Show InChI InChI=1S/C16H12Cl2F4N2O5S/c1-24(2)30(26,27)23-15(25)9-6-11(18)14(7-12(9)19)28-8-3-4-13(10(17)5-8)29-16(20,21)22/h3-7H,1-2H3,(H,23,25)
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n/an/a 218n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275810
PNG
(1-(N-(5-chloro-4-((5- chloro-6-isobutoxy- pyridin-...)
Show SMILES COC(=O)C1CCN(CC1)S(=O)(=O)NC(=O)c1cc(Cl)c(Oc2cnc(OCC(C)C)c(Cl)c2)cc1F
Show InChI InChI=1S/C23H26Cl2FN3O7S/c1-13(2)12-35-22-18(25)8-15(11-27-22)36-20-10-19(26)16(9-17(20)24)21(30)28-37(32,33)29-6-4-14(5-7-29)23(31)34-3/h8-11,13-14H,4-7,12H2,1-3H3,(H,28,30)
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n/an/a 218n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275821
PNG
(5-chloro-4-(((5-chloro- 6-(2,2,3,3-tetrafluoro- pr...)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(COc2cnc(OCC(F)(F)C(F)F)c(Cl)c2)cc1F
Show InChI InChI=1S/C18H16Cl2F5N3O5S/c1-28(2)34(30,31)27-15(29)11-5-12(19)9(3-14(11)21)7-32-10-4-13(20)16(26-6-10)33-8-18(24,25)17(22)23/h3-6,17H,7-8H2,1-2H3,(H,27,29)
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n/an/a 220n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275793
PNG
(5-chloro-4-(3-chloro- 4-(trifluoromethoxy) phenoxy...)
Show SMILES NS(=O)(=O)NC(=O)c1cc(Cl)c(Oc2ccc(OC(F)(F)F)c(Cl)c2)cc1F
Show InChI InChI=1S/C14H8Cl2F4N2O5S/c15-8-3-6(1-2-11(8)27-14(18,19)20)26-12-5-10(17)7(4-9(12)16)13(23)22-28(21,24)25/h1-5H,(H,22,23)(H2,21,24,25)
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n/an/a 226n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275770
PNG
(5-chloro-4-(4-chloro- 3-(trifluoromethyl) phenoxy)...)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(Oc2ccc(Cl)c(c2)C(F)(F)F)cc1F
Show InChI InChI=1S/C16H12Cl2F4N2O4S/c1-24(2)29(26,27)23-15(25)9-6-12(18)14(7-13(9)19)28-8-3-4-11(17)10(5-8)16(20,21)22/h3-7H,1-2H3,(H,23,25)
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n/an/a 253n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275806
PNG
(5-chloro-4-((3,4- dichlorobenzyl)oxy)- N-(N,N-dime...)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OCc2ccc(Cl)c(Cl)c2)cc1F
Show InChI InChI=1S/C16H14Cl3FN2O4S/c1-22(2)27(24,25)21-16(23)10-6-13(19)15(7-14(10)20)26-8-9-3-4-11(17)12(18)5-9/h3-7H,8H2,1-2H3,(H,21,23)
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n/an/a 271n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275856
PNG
(4-((5-chloro-6-iso- butoxypyridin-3-yl) oxy)-5-cya...)
Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2C#N)C(=O)NS(N)(=O)=O)cc1Cl
Show InChI InChI=1S/C17H16ClFN4O5S/c1-9(2)8-27-17-13(18)4-11(7-22-17)28-15-5-14(19)12(3-10(15)6-20)16(24)23-29(21,25)26/h3-5,7,9H,8H2,1-2H3,(H,23,24)(H2,21,25,26)
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n/an/a 290n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275851
PNG
(5-chloro-N-(N,N- dimethylsulfamoyl)-2- fluoro-4-(2...)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(Oc2cc(OC(F)(F)F)ccc2F)cc1F
Show InChI InChI=1S/C16H12ClF5N2O5S/c1-24(2)30(26,27)23-15(25)9-6-10(17)13(7-12(9)19)28-14-5-8(3-4-11(14)18)29-16(20,21)22/h3-7H,1-2H3,(H,23,25)
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n/an/a 340n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275808
PNG
(5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...)
Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)N2CCc3ccccc23)cc1Cl
Show InChI InChI=1S/C24H22Cl2FN3O5S/c1-14(2)13-34-24-19(26)9-16(12-28-24)35-22-11-20(27)17(10-18(22)25)23(31)29-36(32,33)30-8-7-15-5-3-4-6-21(15)30/h3-6,9-12,14H,7-8,13H2,1-2H3,(H,29,31)
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n/an/a 388n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275818
PNG
(5-chloro-4-(((5- chloro-6-(2,2,3,3- tetrafluoropro...)
Show SMILES NS(=O)(=O)NC(=O)c1cc(Cl)c(COc2cnc(OCC(F)(F)C(F)F)c(Cl)c2)cc1F
Show InChI InChI=1S/C16H12Cl2F5N3O5S/c17-10-3-9(13(27)26-32(24,28)29)12(19)1-7(10)5-30-8-2-11(18)14(25-4-8)31-6-16(22,23)15(20)21/h1-4,15H,5-6H2,(H,26,27)(H2,24,28,29)
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n/an/a 460n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275799
PNG
(N-(azepan-1- ylsulfonyl)-5-chloro- 4-((5-chloro-6-...)
Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)N2CCCCCC2)cc1Cl
Show InChI InChI=1S/C22H26Cl2FN3O5S/c1-14(2)13-32-22-18(24)9-15(12-26-22)33-20-11-19(25)16(10-17(20)23)21(29)27-34(30,31)28-7-5-3-4-6-8-28/h9-12,14H,3-8,13H2,1-2H3,(H,27,29)
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n/an/a 542n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275807
PNG
(5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...)
Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)c2cn(C)cn2)cc1Cl
Show InChI InChI=1S/C20H19Cl2FN4O5S/c1-11(2)9-31-20-15(22)4-12(7-24-20)32-17-6-16(23)13(5-14(17)21)19(28)26-33(29,30)18-8-27(3)10-25-18/h4-8,10-11H,9H2,1-3H3,(H,26,28)
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n/an/a 578n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275820
PNG
(5-chloro-4-((5,6- dichloropyridin-3- yl)oxy)-2-flu...)
Show SMILES CNS(=O)(=O)NC(=O)c1cc(Cl)c(Oc2cnc(Cl)c(Cl)c2)cc1F
Show InChI InChI=1S/C13H9Cl3FN3O4S/c1-18-25(22,23)20-13(21)7-3-8(14)11(4-10(7)17)24-6-2-9(15)12(16)19-5-6/h2-5,18H,1H3,(H,20,21)
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n/an/a 628n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275832
PNG
(5-chloro-4-(3,4- difluorophenoxy)- 2-fluoro-N- sul...)
Show SMILES NS(=O)(=O)NC(=O)c1cc(Cl)c(Oc2ccc(F)c(F)c2)cc1F
Show InChI InChI=1S/C13H8ClF3N2O4S/c14-8-4-7(13(20)19-24(18,21)22)10(16)5-12(8)23-6-1-2-9(15)11(17)3-6/h1-5H,(H,19,20)(H2,18,21,22)
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n/an/a 656n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275817
PNG
(5-chloro-4-((5,6- dichloropyridin-3- yl)oxy)-N-(N,...)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(Oc2cnc(Cl)c(Cl)c2)cc1F
Show InChI InChI=1S/C14H11Cl3FN3O4S/c1-21(2)26(23,24)20-14(22)8-4-9(15)12(5-11(8)18)25-7-3-10(16)13(17)19-6-7/h3-6H,1-2H3,(H,20,22)
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n/an/a 665n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275811
PNG
(5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...)
Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)c2cccnc2)cc1Cl
Show InChI InChI=1S/C21H18Cl2FN3O5S/c1-12(2)11-31-21-17(23)6-13(9-26-21)32-19-8-18(24)15(7-16(19)22)20(28)27-33(29,30)14-4-3-5-25-10-14/h3-10,12H,11H2,1-2H3,(H,27,28)
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n/an/a 703n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275804
PNG
(5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...)
Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)Nc2ccc(cc2)C#N)cc1Cl
Show InChI InChI=1S/C23H19Cl2FN4O5S/c1-13(2)12-34-23-19(25)7-16(11-28-23)35-21-9-20(26)17(8-18(21)24)22(31)30-36(32,33)29-15-5-3-14(10-27)4-6-15/h3-9,11,13,29H,12H2,1-2H3,(H,30,31)
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n/an/a 828n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275824
PNG
(5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...)
Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)N2CCNCC2)cc1Cl
Show InChI InChI=1S/C20H23Cl2FN4O5S/c1-12(2)11-31-20-16(22)7-13(10-25-20)32-18-9-17(23)14(8-15(18)21)19(28)26-33(29,30)27-5-3-24-4-6-27/h7-10,12,24H,3-6,11H2,1-2H3,(H,26,28)
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n/an/a 856n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275814
PNG
(4-(3-chloro-4-(tri- fluoromethoxy) phenoxy)-N-(N,N...)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(F)c(Oc2ccc(OC(F)(F)F)c(Cl)c2)cc1F
Show InChI InChI=1S/C16H12ClF5N2O5S/c1-24(2)30(26,27)23-15(25)9-6-12(19)14(7-11(9)18)28-8-3-4-13(10(17)5-8)29-16(20,21)22/h3-7H,1-2H3,(H,23,25)
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n/an/a 860n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275826
PNG
(5-chloro-N-(N,N- dimethylsulfamoyl)- 2-fluoro-4-(4...)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(Oc2ccc(cc2)-c2nccs2)cc1F
Show InChI InChI=1S/C18H15ClFN3O4S2/c1-23(2)29(25,26)22-17(24)13-9-14(19)16(10-15(13)20)27-12-5-3-11(4-6-12)18-21-7-8-28-18/h3-10H,1-2H3,(H,22,24)
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n/an/a 869n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275812
PNG
(US10071957, Example 29 | tert-butyl N-(5-chloro-4-...)
Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl
Show InChI InChI=1S/C21H24Cl2FN3O7S/c1-11(2)10-32-19-15(23)6-12(9-25-19)33-17-8-16(24)13(7-14(17)22)18(28)26-35(30,31)27-20(29)34-21(3,4)5/h6-9,11H,10H2,1-5H3,(H,26,28)(H,27,29)
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n/an/a 905n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275850
PNG
(5-chloro-4-((5-chloro- 6-(2,2,3,3-tetrafluoro- pro...)
Show SMILES FC(F)C(F)(F)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)c2cccnc2)cc1Cl
Show InChI InChI=1S/C20H12Cl2F5N3O5S/c21-13-5-12(17(31)30-36(32,33)11-2-1-3-28-8-11)15(23)6-16(13)35-10-4-14(22)18(29-7-10)34-9-20(26,27)19(24)25/h1-8,19H,9H2,(H,30,31)
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n/an/a 950n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275837
PNG
(4-((1H-indol-6- yl)oxy)-5-chloro-N- (N,N-dimethyl-...)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(Oc2ccc3cc[nH]c3c2)cc1F
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n/an/a 990n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275790
PNG
(5-chloro-4-(4-chloro- 3-(trifluoromethyl) phenoxy)...)
Show SMILES NS(=O)(=O)NC(=O)c1cc(Cl)c(Oc2ccc(Cl)c(c2)C(F)(F)F)cc1F
Show InChI InChI=1S/C14H8Cl2F4N2O4S/c15-9-2-1-6(3-8(9)14(18,19)20)26-12-5-11(17)7(4-10(12)16)13(23)22-27(21,24)25/h1-5H,(H,22,23)(H2,21,24,25)
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n/an/a 1.13E+3n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM275868
PNG
(US10071957, Example 87)
Show SMILES CC(C)Oc1ncc(Oc2cc(F)c(cc2C2CC2)C(=O)NS(=O)(=O)N2CCC2)cc1Cl
Show InChI InChI=1S/C21H23ClFN3O5S/c1-12(2)30-21-17(22)8-14(11-24-21)31-19-10-18(23)16(9-15(19)13-4-5-13)20(27)25-32(28,29)26-6-3-7-26/h8-13H,3-7H2,1-2H3,(H,25,27)
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n/an/a 1.20E+3n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275806
PNG
(5-chloro-4-((3,4- dichlorobenzyl)oxy)- N-(N,N-dime...)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OCc2ccc(Cl)c(Cl)c2)cc1F
Show InChI InChI=1S/C16H14Cl3FN2O4S/c1-22(2)27(24,25)21-16(23)10-6-13(19)15(7-14(10)20)26-8-9-3-4-11(17)12(18)5-9/h3-7H,8H2,1-2H3,(H,21,23)
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n/an/a 1.25E+3n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275839
PNG
(5-chloro-N-(N,N- dimethylsulfamoyl)-2- fluoro-4-ph...)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OCCc2ccccc2)cc1F
Show InChI InChI=1S/C17H18ClFN2O4S/c1-21(2)26(23,24)20-17(22)13-10-14(18)16(11-15(13)19)25-9-8-12-6-4-3-5-7-12/h3-7,10-11H,8-9H2,1-2H3,(H,20,22)
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n/an/a 1.30E+3n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275870
PNG
(US10071957, Example 89)
Show SMILES CC(C)Oc1ncc(Oc2cc(F)c(cc2C2(O)COC2)C(=O)NS(=O)(=O)N2CCC2)cc1Cl
Show InChI InChI=1S/C21H23ClFN3O7S/c1-12(2)32-20-16(22)6-13(9-24-20)33-18-8-17(23)14(7-15(18)21(28)10-31-11-21)19(27)25-34(29,30)26-4-3-5-26/h6-9,12,28H,3-5,10-11H2,1-2H3,(H,25,27)
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n/an/a 1.30E+3n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275782
PNG
(4-((3,4-dichloro- phenoxy)methyl)-N- (N,N-dimethyl...)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1ccc(COc2ccc(Cl)c(Cl)c2)cc1
Show InChI InChI=1S/C16H16Cl2N2O4S/c1-20(2)25(22,23)19-16(21)12-5-3-11(4-6-12)10-24-13-7-8-14(17)15(18)9-13/h3-9H,10H2,1-2H3,(H,19,21)
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n/an/a 1.56E+3n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275810
PNG
(1-(N-(5-chloro-4-((5- chloro-6-isobutoxy- pyridin-...)
Show SMILES COC(=O)C1CCN(CC1)S(=O)(=O)NC(=O)c1cc(Cl)c(Oc2cnc(OCC(C)C)c(Cl)c2)cc1F
Show InChI InChI=1S/C23H26Cl2FN3O7S/c1-13(2)12-35-22-18(25)8-15(11-27-22)36-20-10-19(26)16(9-17(20)24)21(30)28-37(32,33)29-6-4-14(5-7-29)23(31)34-3/h8-11,13-14H,4-7,12H2,1-3H3,(H,28,30)
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n/an/a 1.59E+3n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275845
PNG
(5-chloro-N-(N,N- dimethylsulfamoyl)-2- fluoro-4-((...)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(Oc2ccc3nc(C)sc3c2)cc1F
Show InChI InChI=1S/C17H15ClFN3O4S2/c1-9-20-14-5-4-10(6-16(14)27-9)26-15-8-13(19)11(7-12(15)18)17(23)21-28(24,25)22(2)3/h4-8H,1-3H3,(H,21,23)
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n/an/a 1.90E+3n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275793
PNG
(5-chloro-4-(3-chloro- 4-(trifluoromethoxy) phenoxy...)
Show SMILES NS(=O)(=O)NC(=O)c1cc(Cl)c(Oc2ccc(OC(F)(F)F)c(Cl)c2)cc1F
Show InChI InChI=1S/C14H8Cl2F4N2O5S/c15-8-3-6(1-2-11(8)27-14(18,19)20)26-12-5-10(17)7(4-9(12)16)13(23)22-28(21,24)25/h1-5H,(H,22,23)(H2,21,24,25)
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n/an/a 2.00E+3n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM275784
PNG
(5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...)
Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)N(C)C)cc1Cl
Show InChI InChI=1S/C18H20Cl2FN3O5S/c1-10(2)9-28-18-14(20)5-11(8-22-18)29-16-7-15(21)12(6-13(16)19)17(25)23-30(26,27)24(3)4/h5-8,10H,9H2,1-4H3,(H,23,25)
PDB

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n/an/a 2.18E+3n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275803
PNG
(5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...)
Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)NCc2ccccn2)cc1Cl
Show InChI InChI=1S/C22H21Cl2FN4O5S/c1-13(2)12-33-22-18(24)7-15(11-27-22)34-20-9-19(25)16(8-17(20)23)21(30)29-35(31,32)28-10-14-5-3-4-6-26-14/h3-9,11,13,28H,10,12H2,1-2H3,(H,29,30)
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n/an/a 2.34E+3n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275838
PNG
(5-chloro-N-(N,N- dimethylsulfamoyl)-2- fluoro-4-(4...)
Show SMILES COc1ccc(CCOc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)N(C)C)cc1
Show InChI InChI=1S/C18H20ClFN2O5S/c1-22(2)28(24,25)21-18(23)14-10-15(19)17(11-16(14)20)27-9-8-12-4-6-13(26-3)7-5-12/h4-7,10-11H,8-9H2,1-3H3,(H,21,23)
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n/an/a 2.40E+3n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM275872
PNG
(US10071957, Example 91)
Show SMILES CC(C)Oc1ncc(Oc2cc(F)c(cc2C=C)C(=O)NS(=O)(=O)N2CCC2)cc1Cl
Show InChI InChI=1S/C20H21ClFN3O5S/c1-4-13-8-15(19(26)24-31(27,28)25-6-5-7-25)17(22)10-18(13)30-14-9-16(21)20(23-11-14)29-12(2)3/h4,8-12H,1,5-7H2,2-3H3,(H,24,26)
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n/an/a 2.60E+3n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275804
PNG
(5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...)
Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)Nc2ccc(cc2)C#N)cc1Cl
Show InChI InChI=1S/C23H19Cl2FN4O5S/c1-13(2)12-34-23-19(25)7-16(11-28-23)35-21-9-20(26)17(8-18(21)24)22(31)30-36(32,33)29-15-5-3-14(10-27)4-6-15/h3-9,11,13,29H,12H2,1-2H3,(H,30,31)
PDB

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n/an/a 2.94E+3n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275831
PNG
(5-chloro-4-(3,4- difluorophenoxy)- N-(N,N-dimethyl...)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(Oc2ccc(F)c(F)c2)cc1F
Show InChI InChI=1S/C15H12ClF3N2O4S/c1-21(2)26(23,24)20-15(22)9-6-10(16)14(7-12(9)18)25-8-3-4-11(17)13(19)5-8/h3-7H,1-2H3,(H,20,22)
PDB

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n/an/a 3.47E+3n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM275865
PNG
(US10071957, Example 84)
Show SMILES CC(C)Oc1ncc(Oc2ccc(cc2C2CC2)C(=O)NS(=O)(=O)N2CCC2)cc1Cl
Show InChI InChI=1S/C21H24ClN3O5S/c1-13(2)29-21-18(22)11-16(12-23-21)30-19-7-6-15(10-17(19)14-4-5-14)20(26)24-31(27,28)25-8-3-9-25/h6-7,10-14H,3-5,8-9H2,1-2H3,(H,24,26)
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n/an/a 3.50E+3n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275805
PNG
(5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...)
Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)NCc2cccnc2)cc1Cl
Show InChI InChI=1S/C22H21Cl2FN4O5S/c1-13(2)12-33-22-18(24)6-15(11-27-22)34-20-8-19(25)16(7-17(20)23)21(30)29-35(31,32)28-10-14-4-3-5-26-9-14/h3-9,11,13,28H,10,12H2,1-2H3,(H,29,30)
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n/an/a 3.58E+3n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275796
PNG
(5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...)
Show SMILES CCCCN(CCCC)S(=O)(=O)NC(=O)c1cc(Cl)c(Oc2cnc(OCC(C)C)c(Cl)c2)cc1F
Show InChI InChI=1S/C24H32Cl2FN3O5S/c1-5-7-9-30(10-8-6-2)36(32,33)29-23(31)18-12-19(25)22(13-21(18)27)35-17-11-20(26)24(28-14-17)34-15-16(3)4/h11-14,16H,5-10,15H2,1-4H3,(H,29,31)
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n/an/a 3.64E+3n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275823
PNG
(US10071957, Example 41 | tert-butyl 4-(N-(5-chloro...)
Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)N2CCN(CC2)C(=O)OC(C)(C)C)cc1Cl
Show InChI InChI=1S/C25H31Cl2FN4O7S/c1-15(2)14-37-23-19(27)10-16(13-29-23)38-21-12-20(28)17(11-18(21)26)22(33)30-40(35,36)32-8-6-31(7-9-32)24(34)39-25(3,4)5/h10-13,15H,6-9,14H2,1-5H3,(H,30,33)
PDB

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n/an/a 3.80E+3n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275829
PNG
(5-chloro-N-(N,N- dimethylsulfamoyl)- 2-fluoro-4- (...)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(Oc2ccc3ccccc3c2)cc1F
Show InChI InChI=1S/C19H16ClFN2O4S/c1-23(2)28(25,26)22-19(24)15-10-16(20)18(11-17(15)21)27-14-8-7-12-5-3-4-6-13(12)9-14/h3-11H,1-2H3,(H,22,24)
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n/an/a 4.07E+3n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275801
PNG
(N-(N-benzyl- sulfamoyl)-5- chloro-4-((5- chloro-6-...)
Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)NCc2ccccc2)cc1Cl
Show InChI InChI=1S/C23H22Cl2FN3O5S/c1-14(2)13-33-23-19(25)8-16(12-27-23)34-21-10-20(26)17(9-18(21)24)22(30)29-35(31,32)28-11-15-6-4-3-5-7-15/h3-10,12,14,28H,11,13H2,1-2H3,(H,29,30)
PDB

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n/an/a 4.18E+3n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275803
PNG
(5-chloro-4-((5-chloro- 6-isobutoxypyridin- 3-yl)ox...)
Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)NCc2ccccn2)cc1Cl
Show InChI InChI=1S/C22H21Cl2FN4O5S/c1-13(2)12-33-22-18(24)7-15(11-27-22)34-20-9-19(25)16(8-17(20)23)21(30)29-35(31,32)28-10-14-5-3-4-6-26-14/h3-9,11,13,28H,10,12H2,1-2H3,(H,29,30)
PDB

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n/an/a 4.25E+3n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275802
PNG
(N-(N-benzyl-N- methylsulfamoyl)-5- chloro-4-((5-ch...)
Show SMILES CC(C)COc1ncc(Oc2cc(F)c(cc2Cl)C(=O)NS(=O)(=O)N(C)Cc2ccccc2)cc1Cl
Show InChI InChI=1S/C24H24Cl2FN3O5S/c1-15(2)14-34-24-20(26)9-17(12-28-24)35-22-11-21(27)18(10-19(22)25)23(31)29-36(32,33)30(3)13-16-7-5-4-6-8-16/h4-12,15H,13-14H2,1-3H3,(H,29,31)
PDB

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n/an/a 4.44E+3n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275816
PNG
(5-chloro-4-((5,6- dichloropyridin-3- yl)oxy)-2-flu...)
Show SMILES NS(=O)(=O)NC(=O)c1cc(Cl)c(Oc2cnc(Cl)c(Cl)c2)cc1F
Show InChI InChI=1S/C12H7Cl3FN3O4S/c13-7-2-6(12(20)19-24(17,21)22)9(16)3-10(7)23-5-1-8(14)11(15)18-4-5/h1-4H,(H,19,20)(H2,17,21,22)
PDB

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n/an/a 4.68E+3n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275840
PNG
(5-chloro-N-(N,N- dimethylsulfamoyl)-2- fluoro-4-((...)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(Oc2ccc3[nH]c(C)cc3c2)cc1F
PDB

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n/an/a 5.20E+3n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275834
PNG
(5-chloro-N-(N,N- dimethylsulfamoyl)-2- fluoro-4-(n...)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(Oc2cccc3ccccc23)cc1F
Show InChI InChI=1S/C19H16ClFN2O4S/c1-23(2)28(25,26)22-19(24)14-10-15(20)18(11-16(14)21)27-17-9-5-7-12-6-3-4-8-13(12)17/h3-11H,1-2H3,(H,22,24)
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n/an/a 5.20E+3n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275833
PNG
(5-chloro-N-(N,N- dimethylsulfamoyl)-2- fluoro-4-(2...)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OCCOc2ccccc2)cc1F
Show InChI InChI=1S/C17H18ClFN2O5S/c1-21(2)27(23,24)20-17(22)13-10-14(18)16(11-15(13)19)26-9-8-25-12-6-4-3-5-7-12/h3-7,10-11H,8-9H2,1-2H3,(H,20,22)
PDB

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n/an/a 6.62E+3n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM50118513
PNG
(CHEMBL3617065 | US10071957, Example 6)
Show SMILES CNS(=O)(=O)NC(=O)c1cc(Cl)c(Oc2cnc(OCC(C)C)c(Cl)c2)cc1F
Show InChI InChI=1S/C17H18Cl2FN3O5S/c1-9(2)8-27-17-13(19)4-10(7-22-17)28-15-6-14(20)11(5-12(15)18)16(24)23-29(25,26)21-3/h4-7,9,21H,8H2,1-3H3,(H,23,24)
PDB

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n/an/a 7.18E+3n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275853
PNG
(5-chloro-N-(N,N- dimethylsulfamoyl)-2- fluoro-4-(q...)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(Oc2ccc3ncccc3c2)cc1F
Show InChI InChI=1S/C18H15ClFN3O4S/c1-23(2)28(25,26)22-18(24)13-9-14(19)17(10-15(13)20)27-12-5-6-16-11(8-12)4-3-7-21-16/h3-10H,1-2H3,(H,22,24)
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n/an/a 9.60E+3n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM275867
PNG
(US10071957, Example 86)
Show SMILES COc1ncccc1-c1cc(ccc1Oc1cnc(OC(C)C)c(Cl)c1)C(=O)NS(=O)(=O)N1CCC1
Show InChI InChI=1S/C24H25ClN4O6S/c1-15(2)34-24-20(25)13-17(14-27-24)35-21-8-7-16(22(30)28-36(31,32)29-10-5-11-29)12-19(21)18-6-4-9-26-23(18)33-3/h4,6-9,12-15H,5,10-11H2,1-3H3,(H,28,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275825
PNG
(5-chloro-4-(4-cyano- phenoxy)-N-(N,N- dimethylsulf...)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(Oc2ccc(cc2)C#N)cc1F
Show InChI InChI=1S/C16H13ClFN3O4S/c1-21(2)26(23,24)20-16(22)12-7-13(17)15(8-14(12)18)25-11-5-3-10(9-19)4-6-11/h3-8H,1-2H3,(H,20,22)
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n/an/a 1.00E+4n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275855
PNG
(5-chloro-4-(4-cyano- 3,5-dimethylphenoxy)- N-(N,N-...)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(Oc2cc(C)c(C#N)c(C)c2)cc1F
Show InChI InChI=1S/C18H17ClFN3O4S/c1-10-5-12(6-11(2)14(10)9-21)27-17-8-16(20)13(7-15(17)19)18(24)22-28(25,26)23(3)4/h5-8H,1-4H3,(H,22,24)
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n/an/a 1.10E+4n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275843
PNG
(5-chloro-N-(N,N- dimethylsulfamoyl)-2- fluoro-4-((...)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(Oc2ccc3cnn(C)c3c2)cc1F
Show InChI InChI=1S/C17H16ClFN4O4S/c1-22(2)28(25,26)21-17(24)12-7-13(18)16(8-14(12)19)27-11-5-4-10-9-20-23(3)15(10)6-11/h4-9H,1-3H3,(H,21,24)
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n/an/a 1.40E+4n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275842
PNG
(5-chloro-N-(N,N- dimethylsulfamoyl)-2- fluoro-4-(4...)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(Oc2ccc(cc2)S(C)(=O)=O)cc1F
Show InChI InChI=1S/C16H16ClFN2O6S2/c1-20(2)28(24,25)19-16(21)12-8-13(17)15(9-14(12)18)26-10-4-6-11(7-5-10)27(3,22)23/h4-9H,1-3H3,(H,19,21)
PDB

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UniChem
n/an/a 2.00E+4n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275836
PNG
(4-((1H-indol-4- yl)oxy)-5-chloro-N- (N,N-dimethyl-...)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(Oc2cccc3[nH]ccc23)cc1F
PDB

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UniProtKB/SwissProt

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UniChem
n/an/a 2.00E+4n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275841
PNG
(5-chloro-N-(N,N- dimethylsulfamoyl)-2- fluoro-4-(i...)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(Oc2cccc3cnccc23)cc1F
Show InChI InChI=1S/C18H15ClFN3O4S/c1-23(2)28(25,26)22-18(24)13-8-14(19)17(9-15(13)20)27-16-5-3-4-11-10-21-7-6-12(11)16/h3-10H,1-2H3,(H,22,24)
PDB

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n/an/a 2.00E+4n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275852
PNG
(5-chloro-N-(N,N- dimethylsulfamoyl)-2- fluoro-4-(q...)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(Oc2cccc3ncccc23)cc1F
Show InChI InChI=1S/C18H15ClFN3O4S/c1-23(2)28(25,26)22-18(24)12-9-13(19)17(10-14(12)20)27-16-7-3-6-15-11(16)5-4-8-21-15/h3-10H,1-2H3,(H,22,24)
PDB

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UniChem
n/an/a 2.00E+4n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275854
PNG
(5-chloro-N-(N,N- dimethylsulfamoyl)-2- fluoro-4-(i...)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(Oc2ccc3ccncc3c2)cc1F
Show InChI InChI=1S/C18H15ClFN3O4S/c1-23(2)28(25,26)22-18(24)14-8-15(19)17(9-16(14)20)27-13-4-3-11-5-6-21-10-12(11)7-13/h3-10H,1-2H3,(H,22,24)
PDB

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n/an/a 2.00E+4n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275862
PNG
(US10071957, Example 81)
Show SMILES OC1(COC1)c1cc(ccc1Oc1ccc(OC(F)(F)F)c(Cl)c1)C(=O)NS(=O)(=O)N1CCC1
Show InChI InChI=1S/C20H18ClF3N2O7S/c21-15-9-13(3-5-17(15)33-20(22,23)24)32-16-4-2-12(8-14(16)19(28)10-31-11-19)18(27)25-34(29,30)26-6-1-7-26/h2-5,8-9,28H,1,6-7,10-11H2,(H,25,27)
PDB

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n/an/a 2.02E+4n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM275835
PNG
(5-chloro-2-fluoro-4- (naphthalen-1-yloxy)- N-sulfa...)
Show SMILES NS(=O)(=O)NC(=O)c1cc(Cl)c(Oc2cccc3ccccc23)cc1F
Show InChI InChI=1S/C17H12ClFN2O4S/c18-13-8-12(17(22)21-26(20,23)24)14(19)9-16(13)25-15-7-3-5-10-4-1-2-6-11(10)15/h1-9H,(H,21,22)(H2,20,23,24)
PDB

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n/an/a 2.30E+4n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...


US Patent US10071957 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%