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Found 93 with Last Name = 'mccarthy' and Initial = 'ar'
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
University Of Canterbury

Curated by ChEMBL
LigandPNGBDBM50025356(4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10...)
Affinity DataIC50:  25nMAssay Description:Inhibition of steroid 5alpha reductase type 2 expressed in HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
University Of Canterbury

Curated by ChEMBL
LigandPNGBDBM50025356(4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10...)
Affinity DataIC50:  453nMAssay Description:Inhibition of steroid 5alpha reductase type 1 expressed in HEK 293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM29060(cambinol analog, 6j)
Affinity DataIC50:  1.00E+3nMAssay Description:Compounds were tested for inhibition of sirtuin (SIRT1 or SIRT2) using the human recombinant enzyme provided with the Fluor de Lys fluorescence-based...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM50363783(CHEMBL1945265 | US9365508, 361a (3-Br, 4 tBu))
Affinity DataIC50:  4.60E+3nMAssay Description:Inhibition of recombinant human SitT2 by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM29059(cambinol analog, 6h)
Affinity DataIC50:  4.80E+3nMAssay Description:Compounds were tested for inhibition of sirtuin (SIRT1 or SIRT2) using the human recombinant enzyme provided with the Fluor de Lys fluorescence-based...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM50363775(CHEMBL1945255)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of recombinant human SitT2 by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM50363773(CHEMBL1945137 | US9365508, 331a (4-isopropyl))
Affinity DataIC50:  5.71E+3nMAssay Description:Inhibition of recombinant human SitT2 by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM50363772(CHEMBL1945136)
Affinity DataIC50:  7.85E+3nMAssay Description:Inhibition of recombinant human SitT2 by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM50363774(CHEMBL1945254)
Affinity DataIC50:  8.60E+3nMAssay Description:Inhibition of recombinant human SitT2 by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM99917(4-tert-butyl-N-(4-(5-(dimethylamino)pentanamido)ph...)
Affinity DataIC50:  1.04E+4nMAssay Description:Inhibition of recombinant human SitT2 by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM29057(cambinol analog, 6f)
Affinity DataIC50:  1.05E+4nMAssay Description:Compounds were tested for inhibition of sirtuin (SIRT1 or SIRT2) using the human recombinant enzyme provided with the Fluor de Lys fluorescence-based...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM50363788(CHEMBL1945673)
Affinity DataIC50:  1.24E+4nMAssay Description:Inhibition of recombinant human SitT2 by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM29042(cambinol analog, 6b)
Affinity DataIC50:  1.27E+4nMpH: 8.0 T: 2°CAssay Description:Compounds were tested for inhibition of sirtuin (SIRT1 or SIRT2) using the human recombinant enzyme provided with the Fluor de Lys fluorescence-based...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM50363768(CHEMBL1945131)
Affinity DataIC50:  1.28E+4nMAssay Description:Inhibition of recombinant human SitT2 by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM99922(CHEMBL1945132 | US8501991, 6)
Affinity DataIC50:  1.60E+4nMAssay Description:SIRT1 inhibition assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM99922(CHEMBL1945132 | US8501991, 6)
Affinity DataIC50:  1.61E+4nMAssay Description:Inhibition of recombinant human SitT1 by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM50363788(CHEMBL1945673)
Affinity DataIC50:  1.79E+4nMAssay Description:Inhibition of recombinant human SitT1 by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM50363783(CHEMBL1945265 | US9365508, 361a (3-Br, 4 tBu))
Affinity DataIC50:  1.83E+4nMAssay Description:Inhibition of recombinant human SitT1 by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM29056(cambinol analog, 6e)
Affinity DataIC50:  2.01E+4nMAssay Description:Compounds were tested for inhibition of sirtuin (SIRT1 or SIRT2) using the human recombinant enzyme provided with the Fluor de Lys fluorescence-based...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM99917(4-tert-butyl-N-(4-(5-(dimethylamino)pentanamido)ph...)
Affinity DataIC50:  2.10E+4nMAssay Description:SIRT1 inhibition assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM50363782(CHEMBL1945264 | US9365508, A6 (3-Br))
Affinity DataIC50:  2.12E+4nMAssay Description:Inhibition of recombinant human SitT2 by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM99922(CHEMBL1945132 | US8501991, 6)
Affinity DataIC50:  2.13E+4nMAssay Description:Inhibition of recombinant human SitT2 by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM99918(CHEMBL1945672 | US8501991, 24)
Affinity DataIC50:  2.17E+4nMAssay Description:Inhibition of recombinant human SitT1 by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM29058(cambinol analog, 6g)
Affinity DataIC50:  2.22E+4nMAssay Description:Compounds were tested for inhibition of sirtuin (SIRT1 or SIRT2) using the human recombinant enzyme provided with the Fluor de Lys fluorescence-based...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM99920(CHEMBL1945133 | US8501991, 7)
Affinity DataIC50:  2.47E+4nMAssay Description:Inhibition of recombinant human SitT1 by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM99920(CHEMBL1945133 | US8501991, 7)
Affinity DataIC50:  2.50E+4nMAssay Description:SIRT1 inhibition assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM99918(CHEMBL1945672 | US8501991, 24)
Affinity DataIC50:  2.90E+4nMAssay Description:SIRT1 inhibition assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM50363784(CHEMBL1945266 | US9365508, 311d (3,4-Cl2))
Affinity DataIC50:  3.19E+4nMAssay Description:Inhibition of recombinant human SitT2 by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM99919(US8501991, 5)
Affinity DataIC50:  3.20E+4nMAssay Description:SIRT1 inhibition assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM50363768(CHEMBL1945131)
Affinity DataIC50:  3.58E+4nMAssay Description:Inhibition of recombinant human SitT1 by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM50363775(CHEMBL1945255)
Affinity DataIC50:  3.67E+4nMAssay Description:Inhibition of recombinant human SitT1 by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM99917(4-tert-butyl-N-(4-(5-(dimethylamino)pentanamido)ph...)
Affinity DataIC50:  3.75E+4nMAssay Description:Inhibition of recombinant human SitT1 by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM29055(cambinol analog, 6xi)
Affinity DataIC50:  3.83E+4nMpH: 8.0 T: 2°CAssay Description:Compounds were tested for inhibition of sirtuin (SIRT1 or SIRT2) using the human recombinant enzyme provided with the Fluor de Lys fluorescence-based...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM50363782(CHEMBL1945264 | US9365508, A6 (3-Br))
Affinity DataIC50:  3.99E+4nMAssay Description:Inhibition of recombinant human SitT1 by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM29040(cambinol)
Affinity DataIC50:  4.07E+4nMpH: 8.0 T: 2°CAssay Description:Compounds were tested for inhibition of sirtuin (SIRT1 or SIRT2) using the human recombinant enzyme provided with the Fluor de Lys fluorescence-based...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM99920(CHEMBL1945133 | US8501991, 7)
Affinity DataIC50:  4.17E+4nMAssay Description:Inhibition of recombinant human SitT2 by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM50363785(CHEMBL1945670 | US9365508, A1 (2-Me))
Affinity DataIC50:  4.25E+4nMAssay Description:Inhibition of recombinant human SitT2 by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM50363773(CHEMBL1945137 | US9365508, 331a (4-isopropyl))
Affinity DataIC50:  4.27E+4nMAssay Description:Inhibition of recombinant human SitT1 by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM29045(cambinol analog, 6i)
Affinity DataIC50:  4.30E+4nMpH: 8.0 T: 2°CAssay Description:Compounds were tested for inhibition of sirtuin (SIRT1 or SIRT2) using the human recombinant enzyme provided with the Fluor de Lys fluorescence-based...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM29046(cambinol analog, 6ii)
Affinity DataIC50:  4.42E+4nMpH: 8.0 T: 2°CAssay Description:Compounds were tested for inhibition of sirtuin (SIRT1 or SIRT2) using the human recombinant enzyme provided with the Fluor de Lys fluorescence-based...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM29047(cambinol analog, 6iii)
Affinity DataIC50:  4.45E+4nMpH: 8.0 T: 2°CAssay Description:Compounds were tested for inhibition of sirtuin (SIRT1 or SIRT2) using the human recombinant enzyme provided with the Fluor de Lys fluorescence-based...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM50363774(CHEMBL1945254)
Affinity DataIC50:  4.63E+4nMAssay Description:Inhibition of recombinant human SitT1 by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM29040(cambinol)
Affinity DataIC50:  4.79E+4nMAssay Description:Compounds were tested for inhibition of sirtuin (SIRT1 or SIRT2) using the human recombinant enzyme provided with the Fluor de Lys fluorescence-based...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM29054(cambinol analog, 6x)
Affinity DataIC50:  5.00E+4nMpH: 8.0 T: 2°CAssay Description:Compounds were tested for inhibition of sirtuin (SIRT1 or SIRT2) using the human recombinant enzyme provided with the Fluor de Lys fluorescence-based...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM50363778(CHEMBL1945258)
Affinity DataIC50:  5.06E+4nMAssay Description:Inhibition of recombinant human SitT2 by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM50363780(CHEMBL1945260 | US9365508, B5 (4-Br))
Affinity DataIC50:  5.50E+4nMAssay Description:Inhibition of recombinant human SitT2 by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM99921(CHEMBL1945134 | US8501991, 8)
Affinity DataIC50: >6.00E+4nMAssay Description:SIRT1 inhibition assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM99921(CHEMBL1945134 | US8501991, 8)
Affinity DataIC50: >6.00E+4nMAssay Description:Inhibition of recombinant human SitT1 by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM50363772(CHEMBL1945136)
Affinity DataIC50:  6.02E+4nMAssay Description:Inhibition of recombinant human SitT1 by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
University of St. Andrews

LigandPNGBDBM50363784(CHEMBL1945266 | US9365508, 311d (3,4-Cl2))
Affinity DataIC50:  7.09E+4nMAssay Description:Inhibition of recombinant human SitT1 by Fluor de Lys fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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