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Found 399 with Last Name = 'smith' and Initial = 'bd'
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50280216(Borinic acid derivative | CHEMBL31523 | Phenyl but...)
Affinity DataKi:  1.00E+3nMAssay Description:Compound was tested for the inhibition of subtilisinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetChymotrypsinogen A(Bos taurus (bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM50280216(Borinic acid derivative | CHEMBL31523 | Phenyl but...)
Affinity DataKi:  8.00E+3nMAssay Description:Compound was tested for the inhibition of chymotrypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetChymotrypsinogen A(Bos taurus (bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM50067889(CHEMBL81556 | Diphenyl Borinic acid)
Affinity DataKi:  2.00E+4nMAssay Description:Compound was tested for the inhibition of chymotrypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50067889(CHEMBL81556 | Diphenyl Borinic acid)
Affinity DataKi:  3.00E+4nMAssay Description:Compound was tested for the inhibition of subtilisinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetChymotrypsinogen A(Bos taurus (bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM50283476(CHEMBL78562 | Phenyl methyl borinic acid)
Affinity DataKi:  3.00E+4nMAssay Description:Compound was tested for the inhibition of chymotrypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine protease 1(Bos taurus (bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM50067889(CHEMBL81556 | Diphenyl Borinic acid)
Affinity DataKi:  1.70E+5nMAssay Description:Compound was tested for the inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM26996(CHEMBL21485 | PhB(OH)2 | Phenyl-boronic acid | Phe...)
Affinity DataKi:  4.70E+5nMAssay Description:Compound was tested for the inhibition of subtilisinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetChymotrypsinogen A(Bos taurus (bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM26996(CHEMBL21485 | PhB(OH)2 | Phenyl-boronic acid | Phe...)
Affinity DataKi:  6.40E+5nMAssay Description:Compound was tested for the inhibition of chymotrypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine protease 1(Bos taurus (bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM26996(CHEMBL21485 | PhB(OH)2 | Phenyl-boronic acid | Phe...)
Affinity DataKi:  1.02E+7nMAssay Description:Compound was tested for the inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50096333(CHEMBL3577114)
Affinity DataIC50:  0.460nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50096333(CHEMBL3577114)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant BRAF V600E mutant (unknown origin) assessed as ADP formation measured for 5 hrs by pyruvate kinase/lactate dehydrogenase co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50096332(CHEMBL3577115)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of recombinant BRAF V600E mutant (unknown origin) assessed as ADP formation measured for 5 hrs by pyruvate kinase/lactate dehydrogenase co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50096323(CHEMBL3577123)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of wild type CRAF (unknown origin) assessed as ADP formation measured for 5 hrs by pyruvate kinase/lactate dehydrogenase coupled assay in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50096325(CHEMBL3577120)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of wild type CRAF (unknown origin) assessed as ADP formation measured for 5 hrs by pyruvate kinase/lactate dehydrogenase coupled assay in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589660(CHEMBL5193071)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human CSF1R (542 to 919 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50177716(CHEMBL3813873 | US11679110, Compound Pexidartinib ...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human CSF1R (542 to 919 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50177716(CHEMBL3813873 | US11679110, Compound Pexidartinib ...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human CSF1R (542 to 919 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50096332(CHEMBL3577115)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50096323(CHEMBL3577123)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant BRAF V600E mutant (unknown origin) assessed as ADP formation measured for 5 hrs by pyruvate kinase/lactate dehydrogenase co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589670(CHEMBL5183210)
Affinity DataIC50:  2nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human CSF1R (542 to 919 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50177716(CHEMBL3813873 | US11679110, Compound Pexidartinib ...)
Affinity DataIC50:  2.20nMAssay Description:The activity of CSF1R kinase (CSF1R, SEQ ID NO: 1) was determined spectroscopically using a coupled pyruvate kinase/lactate dehydrogenase assay that ...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589669(DCC-3014 | DP-6865 | Dcc-3014 | US11679110, Compou...)
Affinity DataIC50:  2.20nMAssay Description:The activity of CSF1R kinase (CSF1R, SEQ ID NO: 1) was determined spectroscopically using a coupled pyruvate kinase/lactate dehydrogenase assay that ...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589694(CHEMBL5170451)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human CSF1R (542 to 919 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589686(CHEMBL5197168)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human CSF1R (542 to 919 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50096328(CHEMBL3577119)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of wild type CRAF (unknown origin) assessed as ADP formation measured for 5 hrs by pyruvate kinase/lactate dehydrogenase coupled assay in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589672(CHEMBL5176985)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human CSF1R (542 to 919 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50096332(CHEMBL3577115)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of wild type CRAF (unknown origin) assessed as ADP formation measured for 5 hrs by pyruvate kinase/lactate dehydrogenase coupled assay in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50096325(CHEMBL3577120)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant BRAF V600E mutant (unknown origin) assessed as ADP formation measured for 5 hrs by pyruvate kinase/lactate dehydrogenase co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589678(CHEMBL5181597)
Affinity DataIC50:  3nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human CSF1R (542 to 919 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589669(DCC-3014 | DP-6865 | Dcc-3014 | US11679110, Compou...)
Affinity DataIC50:  3nMAssay Description:Inhibition of CSF1R (unknown origin) in presence of 4 mM ATP measured by cell-based spectrophotometric assayMore data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50096333(CHEMBL3577114)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of wild type CRAF (unknown origin) assessed as ADP formation measured for 5 hrs by pyruvate kinase/lactate dehydrogenase coupled assay in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589675(CHEMBL5176270)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human CSF1R (542 to 919 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589679(CHEMBL5170039)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human CSF1R (542 to 919 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589661(CHEMBL5200885)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human CSF1R (542 to 919 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589674(CHEMBL5186979)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human CSF1R (542 to 919 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589669(DCC-3014 | DP-6865 | Dcc-3014 | US11679110, Compou...)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human CSF1R (542 to 919 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589677(CHEMBL5174778)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human CSF1R (542 to 919 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589676(CHEMBL5177368)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human CSF1R (542 to 919 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589680(CHEMBL5195204)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human CSF1R (542 to 919 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50096331(CHEMBL3577116)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of recombinant BRAF V600E mutant (unknown origin) assessed as ADP formation measured for 5 hrs by pyruvate kinase/lactate dehydrogenase co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50096279(CHEMBL3577124)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of wild type CRAF (unknown origin) assessed as ADP formation measured for 5 hrs by pyruvate kinase/lactate dehydrogenase coupled assay in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50096329(CHEMBL3577118)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of recombinant BRAF V600E mutant (unknown origin) assessed as ADP formation measured for 5 hrs by pyruvate kinase/lactate dehydrogenase co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50096323(CHEMBL3577123)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of wild type BRAF (unknown origin) assessed as ADP formation measured for 5 hrs by pyruvate kinase/lactate dehydrogenase coupled assay in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589662(CHEMBL5192630)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human CSF1R (542 to 919 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50507257(CHEMBL4475116)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50328774(2-(3-(3-cyclopentyl-5-(3-(2,3-dichlorophenyl)ureid...)
Affinity DataIC50:  5nMAssay Description:Binding affinity to unphosphorylated p38alpha by fluoroprobe binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50398716(CHEMBL2179618 | US10227295, Compound 5g | US940985...)
Affinity DataIC50:  5nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589676(CHEMBL5177368)
Affinity DataIC50:  5.10nMAssay Description:Inhibition of N-terminal GST-tagged PDGFRalpha (unknown origin) (550 to 1089 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Deciphera Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589675(CHEMBL5176270)
Affinity DataIC50:  5.10nMAssay Description:Inhibition of N-terminal GST-tagged PDGFRalpha (unknown origin) (550 to 1089 residues) measured by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50096331(CHEMBL3577116)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of wild type CRAF (unknown origin) assessed as ADP formation measured for 5 hrs by pyruvate kinase/lactate dehydrogenase coupled assay in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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