BDBM50386885 CANAGLIFLOZIN::CANAGLIFLOZIN HYDRATE::US10752604, Example Canagliflozin
SMILES Cc1ccc(cc1Cc1ccc(s1)-c1ccc(F)cc1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
InChI Key InChIKey=XTNGUQKDFGDXSJ-ZXGKGEBGSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 15 hits for monomerid = 50386885
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human SGLT2 expressed in CHOK cells assessed as reduction of [14C]alpha-methyl-D-glucopyranoside uptake after 120 mins by liquid scinti...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 2.20nMAssay Description:Inhibition of human SGLT2 by liquid scintillation counter analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of human SGLT1 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as decrease in uptake of [14C]AMG after 120 mins by TopCount methodMore data for this Ligand-Target Pair
Affinity DataIC50: 265nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as decrease in uptake of [14C]AMG after 120 mins by TopCount methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 550nMAssay Description:To analyze a sodium-dependent glucose transport, cells for expressing hSGLT1 and hSGLT2 were seeded at 1×105 cells per well into a 96-well culture pl...More data for this Ligand-Target Pair
Affinity DataIC50: 4.90nMAssay Description:To analyze a sodium-dependent glucose transport, cells for expressing hSGLT1 and hSGLT2 were seeded at 1×105 cells per well into a 96-well culture pl...More data for this Ligand-Target Pair
Affinity DataIC50: 4.40nMAssay Description:Inhibition of human SGLT2More data for this Ligand-Target Pair
Affinity DataIC50: 684nMAssay Description:Inhibition of human SGLT1More data for this Ligand-Target Pair
Affinity DataEC50: 910nMAssay Description:Inhibition of SGLT1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 2.20nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.40nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 710nMAssay Description:Inhibition of SGLT1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 6.70nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair