BDBM15138 5-indazolyl pyridine 11g::5-{5-[(2S)-2-amino-3-phenylpropoxy]pyridin-3-yl}-3-methyl-1H-indazole::A-674563::Biochemistry 469551 Compound 11::indazole-pyridine, 7
SMILES Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccccc2)c1
InChI Key InChIKey=BPNUQXPIQBZCMR-IBGZPJMESA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 455 hits for monomerid = 15138
TargetRAC-alpha serine/threonine-protein kinase [139-480,S378A,S381A,T450D,S473D](Human)
Abbott Laboratories
Abbott Laboratories
Affinity DataKi: 11nM ΔG°: -10.7kcal/molepH: 7.5 T: 22°CAssay Description:The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...More data for this Ligand-Target Pair
Affinity DataKi: 16nM ΔG°: -10.5kcal/molepH: 7.4 T: 22°CAssay Description:The kinase assay uses purified recombinant enzyme and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidi...More data for this Ligand-Target Pair
Affinity DataKi: 8.90E+3nMAssay Description:Kinase was assayed in 384-well polypropylene plate format. The compound was mixed with kinase and biotinylated peptide substrate and incubated. After...More data for this Ligand-Target Pair
Affinity DataKi: >2.00E+4nMAssay Description:Kinase was assayed in 384-well polypropylene plate format. The compound was mixed with kinase and biotinylated peptide substrate and incubated. After...More data for this Ligand-Target Pair
Affinity DataKi: >2.00E+4nMAssay Description:Kinase was assayed in 384-well polypropylene plate format. The compound was mixed with kinase and biotinylated peptide substrate and incubated. After...More data for this Ligand-Target Pair
Affinity DataKi: >2.00E+4nM ΔG°: >-6.34kcal/molepH: 7.5 T: 22°CAssay Description:Kinase was assayed in 384-well polypropylene plate format. The compound was mixed with kinase and biotinylated peptide substrate and incubated. After...More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase [139-480,S378A,S381A,T450D,S473D](Human)
Abbott Laboratories
Abbott Laboratories
Affinity DataIC50: 14nMpH: 7.5 T: 22°CAssay Description:The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...More data for this Ligand-Target Pair
Affinity DataIC50: 16nMpH: 7.5 T: 22°CAssay Description:The kinase assay uses purified recombinant enzyme and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidi...More data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for CDC2L2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 9.5nMAssay Description:Binding constant for PRKCH kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for TNNI3K kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for EGFR(L747-T751del,Sins) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for EGFR(G719C) kinase domainMore data for this Ligand-Target Pair
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Human)
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for IKK-alpha kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for ABL1(F317I)-nonphosphorylated kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for MET(Y1235D) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for BRSK1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 1.10E+3nMAssay Description:Binding constant for SRPK2 kinase domainMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for PIK3CA(E545K) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for ABL1(F317I)-phosphorylated kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for ROCK2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for CHEK1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for EGFR(L858R,T790M) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for RSK4(Kin.Dom.2-C-terminal) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for EPHA6 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 740nMAssay Description:Binding constant for CAMKK2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for EGFR(E746-A750del) kinase domainMore data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type II subunit beta(Human)
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 970nMAssay Description:Binding constant for CAMK2B kinase domainMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for PIK3CA(Q546K) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 200nMAssay Description:Binding constant for FLT3(N841I) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for KIT kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 870nMAssay Description:Binding constant for MYLK kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 1.60E+3nMAssay Description:Binding constant for DAPK1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for KIT(L576P) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for EGFR kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for INSR kinase domainMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for PIK3CA(I800L) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for RPS6KA4(Kin.Dom.1-N-terminal) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for KIT(V559D,V654A) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for ABL1-nonphosphorylated kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for EGFR(T790M) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for MYO3B kinase domainMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for PIK3CA(H1047Y) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for ABL1(Q252H)-phosphorylated kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 92nMAssay Description:Binding constant for DMPK kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 500nMAssay Description:Binding constant for FLT3(K663Q) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 43nMAssay Description:Binding constant for AAK1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for JAK1(JH2domain-pseudokinase) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for KIT(A829P) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for ABL1(H396P)-nonphosphorylated kinase domainMore data for this Ligand-Target Pair